Research map: When less is more: loss of IRAK2 signalling promotes inflammation
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Papers in this map
Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency
· Capucine Pïcard · 2003 · 829 citations · Cited by this paper
Brepocitinib shows promise for dermatomyositis
· 2026 · Related
Infectious Diseases in Patients with IRAK-4, MyD88, NEMO, or IκBα Deficiency
· Capucine Pïcard · 2011 · 393 citations · Cited by this paper
The gut–joint axis in osteoarthritis
· 2026 · Related
Human inborn errors of immunity: 2024 update on the classification from the International Union of Immunological Societies Expert Committee
· M. Cecilia Poli · 2025 · 333 citations · Cited by this paper
Anti-CD19 CAR T cell therapy promotes skin remodelling in systemic sclerosis
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Understanding early TLR signaling through the Myddosome
· Katherine R. Balka · 2018 · 199 citations · Cited by this paper
Progress made and the road ahead for cancer screening in myositis
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Emerging concepts of type I interferons in SLE pathogenesis and therapy
· Antonios Psarras · 2022 · 135 citations · Cited by this paper
20 years of progress in the classification of immune-mediated diseases
· 2026 · Related
Regulation of innate immune signaling by IRAK proteins
· Milton C. A. Pereira · 2023 · 131 citations · Cited by this paper
The evolving comorbidity landscape of rheumatoid arthritis
· 2026 · Related
Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus
· Raphaela T. Goldbach‐Mansky · 2024 · 41 citations · Cited by this paper
Decoding variants of uncertain significance in systemic autoinflammatory diseases
· 2026 · Related
Copy Number Analysis in a Large Cohort Suggestive of Inborn Errors of Immunity Indicates a Wide Spectrum of Relevant Chromosomal Losses and Gains
· Rensheng Wan · 2022 · 22 citations · Cited by this paper
Sex-dependent mechanisms in rheumatic diseases
· 2026 · Related
Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4
· Samantha Cooray · 2023 · 17 citations · Cited by this paper
Rethinking early-stage knee osteoarthritis beyond radiography
· 2026 · Related
IRAK2 deficiency causes immune dysregulation through defective Myddosome assembly and enhanced interferon responses
· Yudie Fei · 2026 · 2 citations · Cited by this paper
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