Research map: CRISPR-Cas Systems as Precision Antimicrobials: Reversing the Tide of Antimicrobial Resistance

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  1. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity · Martin Jínek · 2012 · 17808 citations · Cited by this paper
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  11. Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System · Bernd Zetsche · 2015 · 5042 citations · Cited by this paper
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  13. CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity · Janice S. Chen · 2018 · 4638 citations · Cited by this paper
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  15. Nucleic acid detection with CRISPR-Cas13a/C2c2 · Jonathan S. Gootenberg · 2017 · 4007 citations · Cited by this paper
  16. CRISPR-Cas9-mediated elimination of plasmid-borne carbapenemase genes restores ertapenem susceptibility in clinical Klebsiella pneumoniae isolates · 2026 · Related
  17. Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050 · Mohsen Naghavi · 2024 · 3685 citations · Cited by this paper
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  19. Understanding the mechanisms and drivers of antimicrobial resistance · Alison Holmes · 2015 · 2704 citations · Cited by this paper
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  21. Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants · Kira S. Makarova · 2019 · 2563 citations · Cited by this paper
  22. C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector · Omar O. Abudayyeh · 2016 · 2464 citations · Cited by this paper
  23. Antibiotics: past, present and future · Matthew I. Hutchings · 2019 · 2436 citations · Cited by this paper
  24. Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019 · Kevin Shunji Ikuta · 2022 · 2272 citations · Cited by this paper
  25. Antimicrobial Resistance in ESKAPE Pathogens · David M. P. De Oliveira · 2020 · 2141 citations · Cited by this paper
  26. Programmed DNA destruction by miniature CRISPR-Cas14 enzymes · Lucas B. Harrington · 2018 · 1296 citations · Cited by this paper
  27. Applications of CRISPR technologies in research and beyond · Rodolphe Barrangou · 2016 · 1058 citations · Cited by this paper
  28. Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials · David Bikard · 2014 · 1017 citations · Cited by this paper
  29. Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases · Robert J. Citorik · 2014 · 838 citations · Cited by this paper
  30. A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria · Jason M. Peters · 2016 · 809 citations · Cited by this paper
  31. Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy · Frank Oechslin · 2018 · 613 citations · Cited by this paper
  32. Horizontal Gene Transfer of Antibiotic Resistance Genes in Biofilms · Claudia Michaelis · 2023 · 602 citations · Cited by this paper
  33. Origins and evolution of CRISPR-Cas systems · Eugene V. Koonin · 2019 · 514 citations · Cited by this paper
  34. Temperate and lytic bacteriophages programmed to sensitize and kill antibiotic-resistant bacteria · Ido Yosef · 2015 · 503 citations · Cited by this paper
  35. Cas3 is a single‐stranded DNA nuclease and ATP‐dependent helicase in the CRISPR/Cas immune system · Tomas Šinkūnas · 2011 · 466 citations · Cited by this paper
  36. Genetically Engineered Phages: a Review of Advances over the Last Decade · Diana Priscila Pires · 2016 · 433 citations · Cited by this paper
  37. Genetically stable CRISPR-based kill switches for engineered microbes · Austin G. Rottinghaus · 2022 · 284 citations · Cited by this paper
  38. Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria · Kotaro Kiga · 2020 · 246 citations · Cited by this paper
  39. Evolutionary dynamics of CRISPR gene drives · Charleston Noble · 2017 · 223 citations · Cited by this paper

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