Research map: Smoothened signaling in microglia: canonical or not, and does it promote or limit inflammation?

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Papers in this map

  1. Activation of Sonic hedgehog signal by Purmorphamine, in a mouse model of Parkinson's disease, protects dopaminergic neurons and attenuates inflammatory response by mediating PI3K/AKt signaling pathway · Shuai Shao · 2017 · 72 citations · Cited by this paper
  2. Adenosine receptor signaling in vascular diseases: from molecular mechanisms to targeted therapeutics · 2026 · Related
  3. Targeting GLI Transcription Factors in Cancer · Miroslava Didiášová · 2018 · 72 citations · Cited by this paper
  4. Macrophage FOLR2 drives liver fibrosis via intercellular engagement of TGFβRII · 2026 · Related
  5. Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma · Changju Qu · 2013 · 41 citations · Cited by this paper
  6. Cardiomyocyte OTUD7b drives diabetic cardiomyopathy via deubiquitinating and stabilizing TAK1 · 2026 · Related
  7. Functional cooperation of the hedgehog and androgen signaling pathways during developmental and repairing myelination · Yousra Laouarem · 2021 · 29 citations · Cited by this paper
  8. Astrocytic adrenergic α2 receptor contributes to the mechanisms underlying the circadian rhythmicity of seizure susceptibility · 2026 · Related
  9. Hedgehog dysregulation contributes to tissue-specific inflammaging of resident macrophages · Mahamat Babagana · 2021 · 19 citations · Cited by this paper
  10. The solute carrier transporter SLCO5A1 as a novel therapeutic target for the treatment of myocardial infarction-induced heart failure · 2026 · Related
  11. The Smoothened agonist SAG Modulates the Male and Female Peripheral Immune Systems Differently in an Immune Model of Central Nervous System Demyelination · Abdelmoumen Kassoussi · 2024 · 7 citations · Cited by this paper
  12. Serum/glucocorticoid-regulated kinase 1 regulates vascular inflammation in atherosclerosis · 2026 · Related
  13. Sonidegib Suppresses Production of Inflammatory Mediators and Cell Migration in BV2 Microglial Cells and Mice Treated with Lipopolysaccharide via JNK and NF-κB Inhibition · Ngoc Minh Nguyen · 2022 · 4 citations · Cited by this paper
  14. METTL3 loss exacerbates colitis via m6A-dependent Slc39a8 regulation and epithelial lineage depletion · 2026 · Related
  15. Smoothened-mediated signaling contributes to immune and non-immune functions of microglia · Adil El Mesaoudi · 2025 · 4 citations · Cited by this paper
  16. Secreted chimeric proteins as a strategy to correct SOX17 deficiency and attenuate the malignant phenotype of cholangiocarcinoma cells: a proof-of-concept study · 2026 · Related
  17. Lessons from ex vivo and in vitro models in microglia research · Csaba Cserép · 2025 · 3 citations · Cited by this paper
  18. Activation of peripheral muscarinic receptors rescues depressive-like behaviors via gut-brain-axis, involving parasympathetic excitation · 2026 · Related
  19. Sonic Hedgehog-Gli1 signaling promotes microglial activation via the IKKβ/NF-κB pathway · Zhi-rou Xu · 2026 · 1 citation · Cited by this paper
  20. Molecular mechanisms for sustaining cancer stem cells characteristics and targeted therapeutic strategies · 2026 · Related

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