Research map: Pivotal Clinical Trials on the Management of Diverticular Disease

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  1. Natural History of Diverticular Disease of the Colon · T G Parks · 1975 · 641 citations · Cited by this paper
  2. Medical Management of Inflammatory Pouch Disorders · 2025 · Related
  3. Randomized clinical trial of antibiotics in acute uncomplicated diverticulitis13 · for the AVOD Study Group · 2012 · 557 citations · Cited by this paper
  4. Redo Pelvic Pouch Procedure: Indications, Pitfalls, Technique, and Outcomes · 2025 · Related
  5. Practice parameters for the treatment of sigmoid diverticulitis—Supporting documentation · Douglas W. Wong · 2000 · 436 citations · Cited by this paper
  6. Special Considerations in Anal Fistula Management · 2026 · Related
  7. A Multicenter Randomized Clinical Trial of Primary Anastomosis or Hartmann's Procedure for Perforated Left Colonic Diverticulitis With Purulent or Fecal Peritonitis · Christian Eugen Oberkofler · 2012 · 376 citations · Cited by this paper
  8. Salvaging Anastomoses After a Leak: A Practical Diagnostic and Treatment Algorithm · 2026 · Related
  9. Diagnosis and Management of Diverticular Disease of The Colon in Adults · Neil Stollman · 1999 · 364 citations · Cited by this paper
  10. Advances in Colorectal Anastomoses · 2026 · Related
  11. Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial · Sandra Vennix · 2015 · 341 citations · Cited by this paper
  12. Ileal Pouch Physiology: Clinical Implications · 2026 · Related
  13. Laparoscopic Sigmoid Resection for Diverticulitis Decreases Major Morbidity Rates: A Randomized Control Trial · Bastiaan R. Klarenbeek · 2008 · 336 citations · Cited by this paper
  14. Ileal Anal Pouch Dysfunction and Quality of Life · 2025 · Related
  15. Randomized clinical trial of observational versus antibiotic treatment for a first episode of CT-proven uncomplicated acute diverticulitis · Lidewine Daniels · 2016 · 329 citations · Cited by this paper
  16. The NICE Procedure: Surgical Technique and Technical Considerations · 2026 · Related
  17. Risk of Emergency Colectomy and Colostomy in Patients With Diverticular Disease · Daniel A. Anaya · 2005 · 327 citations · Cited by this paper
  18. Laparoscopic Lavage vs Primary Resection for Acute Perforated Diverticulitis · Johannes Schultz · 2015 · 293 citations · Cited by this paper
  19. Hartmann's Procedure or Primary Anastomosis for Generalized Peritonitis due to Perforated Diverticulitis: A Prospective Multicenter Randomized Trial (DIVERTI) · Valérie Bridoux · 2017 · 242 citations · Cited by this paper
  20. Laparoscopic Lavage Is Feasible and Safe for the Treatment of Perforated Diverticulitis With Purulent Peritonitis · Eva Angenete · 2014 · 241 citations · Cited by this paper
  21. Hartmann's procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES): a multicentre, parallel-group, randomised, open-label, superiority trial · Daniël P. V. Lambrichts · 2019 · 216 citations · Cited by this paper
  22. The timing of elective colectomy in diverticulitis: A decision analysis · Leon Salem · 2004 · 215 citations · Cited by this paper
  23. Long-Term Follow-Up After First Acute Episode of Sigmoid Diverticulitis: Is Surgery Mandatory? · Roland C. Chautems · 2002 · 205 citations · Cited by this paper
  24. Outpatient Versus Hospitalization Management for Uncomplicated Diverticulitis · Sebastiano Biondo · 2013 · 200 citations · Cited by this paper
  25. A Prospective, Randomized, Single-Blind Comparison of Laparoscopic Versus Open Sigmoid Colectomy for Diverticulitis · Pascal Gervaz · 2010 · 179 citations · Cited by this paper
  26. Surgery versus conservative management for recurrent and ongoing left-sided diverticulitis (DIRECT trial): an open-label, multicentre, randomised controlled trial · Bryan J. M. van de Wall · 2016 · 173 citations · Cited by this paper
  27. The 5-year natural history of complicated diverticular disease · N Farmakis · 1994 · 138 citations · Cited by this paper
  28. The Clinical Significance of Diverticulosis · Russell Sage Boles · 1958 · 137 citations · Cited by this paper
  29. The ladies trial: laparoscopic peritoneal lavage or resection for purulent peritonitisA and Hartmann's procedure or resection with primary anastomosis for purulent or faecal peritonitisB in perforated diverticulitis (NTR2037) · Hilko A. Swank · 2010 · 129 citations · Cited by this paper
  30. Hartmann's Colectomy and Reversal in Diverticulitis: A Population-Level Assessment · Leon Salem · 2005 · 129 citations · Cited by this paper
  31. Natural history of diverticular disease · Jyrki Tapani Mäkelä · 1998 · 123 citations · Cited by this paper
  32. Laparoscopic versus open sigmoid resection for diverticular disease: follow-up assessment of the randomized control Sigma trial · Bastiaan R. Klarenbeek · 2010 · 112 citations · Cited by this paper
  33. Long-Term Effects of Omitting Antibiotics in Uncomplicated Acute Diverticulitis · Stefan T. van Dijk · 2018 · 109 citations · Cited by this paper
  34. Surgical management of complicated diverticulitis · Alan W. Hackford · 1985 · 108 citations · Cited by this paper
  35. Two-year results of the randomized clinical trial DILALA comparing laparoscopic lavage with resection as treatment for perforated diverticulitis · Andreas Pagh Kohl · 2018 · 106 citations · Cited by this paper
  36. Long-term follow-up of the AVOD randomized trial of antibiotic avoidance in uncomplicated diverticulitis · Daniel Isacson · 2019 · 93 citations · Cited by this paper
  37. Comparing Laparoscopic Elective Sigmoid Resection With Conservative Treatment in Improving Quality of Life of Patients With Diverticulitis · Alexandre Santos · 2020 · 87 citations · Cited by this paper
  38. Treatment of acute diverticulitis laparoscopic lavage vs. resection (DILALA): study protocol for a randomised controlled trial · Anders Thornell · 2011 · 82 citations · Cited by this paper
  39. A multicenter randomized clinical trial investigating the cost-effectiveness of treatment strategies with or without antibiotics for uncomplicated acute diverticulitis (DIABOLO trial) · Dutch Diverticular Disease (3D) Collaborative Study Group · 2010 · 81 citations · Cited by this paper

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