Research map: The role of the kynurenine pathway in the pathogenesis of pain and affective disorders after traumatic brain injury

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  1. Kynurenines in the mammalian brain: when physiology meets pathology · Robert M. Schwarcz · 2012 · 1555 citations · Cited by this paper
  2. Peripheral blood DNA methylation partially reports on immune cell type composition in the frontal brain · 2026 · Related
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  4. Reduced serum interleukin-2 associates with higher motor severity and along with CD4 T cell alterations may be an early event in isolated REM Sleep Behaviour Disorder · 2026 · Related
  5. The Brain Metabolite Kynurenic Acid Inhibits α7 Nicotinic Receptor Activity and Increases Non-α7 Nicotinic Receptor Expression: Physiopathological Implications · Corey J. Hilmas · 2001 · 864 citations · Cited by this paper
  6. Early amyloid pathology in mice synergistically worsens post-sepsis behavioral impairment and microglial synaptic phagocytosis · 2026 · Related
  7. Prevalence of chronic pain among adults in the United States · Robert Jason Yong · 2021 · 853 citations · Cited by this paper
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  9. Blood–Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism · Shinsuke Fukui · 1991 · 775 citations · Cited by this paper
  10. Vascular inflammation in neuropsychiatric long COVID · 2026 · Related
  11. Major Depression Following Traumatic Brain Injury · Ricardo E. Jorge · 2004 · 752 citations · Cited by this paper
  12. Mania and psychosis following chimeric antigen receptor T-cell therapy: A report of two cases and mechanistic discussion · 2026 · Related
  13. The Role of Markers of Inflammation in Traumatic Brain Injury · Thomas M. Woodcock · 2013 · 725 citations · Cited by this paper
  14. APOE genotype is associated with Ex vivo inflammatory responses in healthy individuals: Potential implications for Alzheimer's disease · 2026 · Related
  15. Prevalence of Chronic Pain After Traumatic Brain Injury · Devi E. Nampiaparampil · 2008 · 680 citations · Cited by this paper
  16. Plasma proteomic profile of inflammatory depressive symptoms · 2026 · Related
  17. Quinolinic acid, the inescapable neurotoxin · Gilles J. Guillemin · 2012 · 623 citations · Cited by this paper
  18. Inflammatory reprogramming of immature oligodendrocytes perturbs myelination and neurodevelopment in a dual-hit model of preterm brain injury · 2026 · Related
  19. Trends in U.S. Depression Prevalence From 2015 to 2020: The Widening Treatment Gap · Renée D. Goodwin · 2022 · 574 citations · Cited by this paper
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  21. Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission? · Johann Steiner · 2011 · 572 citations · Cited by this paper
  22. Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection · Gilles J. Guillemin · 2001 · 543 citations · Cited by this paper
  23. Expression of indoleamine 2,3‐dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons · Gilles J. Guillemin · 2004 · 498 citations · Cited by this paper
  24. Neuroinflammation and Comorbidity of Pain and Depression · Adam K. Walker · 2013 · 470 citations · Cited by this paper
  25. Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation · Carmine Maria Pariante · 2017 · 394 citations · Cited by this paper
  26. Kynurenic Acid: The Janus-Faced Role of an Immunomodulatory Tryptophan Metabolite and Its Link to Pathological Conditions · Elisa Wirthgen · 2018 · 384 citations · Cited by this paper
  27. On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress · Rafael Lugo-Huitrón · 2011 · 355 citations · Cited by this paper
  28. Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression · Hyangin Kim · 2012 · 326 citations · Cited by this paper
  29. The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies · Wolfgang Marx · 2020 · 323 citations · Cited by this paper
  30. Cellular infiltration in traumatic brain injury · Aftab Alam · 2020 · 321 citations · Cited by this paper
  31. Indoleamine 2,3-dioxygenase (IDO) inhibitors and cancer immunotherapy · Yu Fujiwara · 2022 · 310 citations · Cited by this paper
  32. A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality · Cecilie Bay-Richter · 2014 · 304 citations · Cited by this paper
  33. Reduction of Endogenous Kynurenic Acid Formation Enhances Extracellular Glutamate, Hippocampal Plasticity, and Cognitive Behavior · Michelle C Potter · 2010 · 236 citations · Cited by this paper
  34. Oxidative stress as a mechanism for quinolinic acid‐induced hippocampal damage: protection by melatonin and deprenyl · W. M. H. Behan · 1999 · 226 citations · Cited by this paper
  35. Coping strategies in patients with acquired brain injury: relationships between coping, apathy, depression and lesion location · Stein Andersson Arnstein Finset · 2000 · 222 citations · Cited by this paper
  36. Modulation of T cells by tryptophan metabolites in the kynurenine pathway · Trevor W. Stone · 2023 · 220 citations · Cited by this paper
  37. The biochemical origin of pain: The origin of all pain is inflammation and the inflammatory response. Part 2 of 3 – Inflammatory profile of pain syndromes · Sota Omoigui · 2007 · 215 citations · Cited by this paper
  38. Activated human microglia produce the excitotoxin quinolinic acid · Michael Graham Espey · 1997 · 197 citations · Cited by this paper
  39. Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury · Erwin Alexander van Vliet · 2020 · 191 citations · Cited by this paper

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