Research map: P38α deficiency alleviates myocardial ischemia/reperfusion injury by stabilizing c‑Myc to inhibit ferroptosis

Back to the article

Papers in this map

  1. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer · Patrick J. Roberts · 2007 · 2825 citations · Cited by this paper
  2. Peroxisomal catalase and plasmalogen biosynthesis protect from oxidative stress in Barth syndrome cardiomyopathy · 2026 · Related
  3. The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease · Xuexian Fang · 2022 · 1108 citations · Cited by this paper
  4. Single cell and spatial transcriptomic profiling of the type 2 diabetic coronary microcirculation and myocardium · 2025 · Related
  5. Mechanisms controlling cellular and systemic iron homeostasis · Bruno Galy · 2023 · 784 citations · Cited by this paper
  6. Coronary endothelial cells undergo venous-enriched disrupted maturation following myocardial infarction · 2026 · Related
  7. The interaction between ferroptosis and inflammatory signaling pathways · Yue Chen · 2023 · 564 citations · Cited by this paper
  8. Cardiac unloading models for myocardial reverse remodeling · 2026 · Related
  9. Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Cardiomyocyte Ferroptosis · Wenbin Cai · 2023 · 452 citations · Cited by this paper
  10. miR-144 targets in myocardial hypertrophy and coronary microvascular dysfunction in hypertrophic cardiomyopathy: molecular research meets imaging · 2026 · Related
  11. Regulated cell death in myocardial ischemia–reperfusion injury · Qi Xiang · 2023 · 451 citations · Cited by this paper
  12. Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP-P2X7-NLRP3 inflammasome axis · 2025 · Related
  13. GPX4, ferroptosis, and diseases · Wangzheqi Zhang · 2024 · 416 citations · Cited by this paper
  14. The role of NO, H2O2, and non-NO/H2O2 mechanisms in acetylcholine (ACh)-induced dilation of human arterioles in the absence and presence of coronary artery disease · 2025 · Related
  15. Characterization of the c-MYC-regulated transcriptome by SAGE: Identification and analysis of c-MYC target genes · Antje Menssen · 2002 · 406 citations · Cited by this paper
  16. Functional consequences of diminished myocardial oxygen delivery per beat in experimental heart failure · 2026 · Related
  17. Protein kinase activation and myocardial ischemia/reperfusion injury · Stephen Armstrong · 2003 · 334 citations · Cited by this paper
  18. A high-fat diet nutritional intervention reprograms cardiac metabolism and improves systolic function in a pig model of heart failure with reduced ejection fraction · 2026 · Related
  19. The Role of NCOA4-Mediated Ferritinophagy in Ferroptosis · Naiara Santana-Codina · 2021 · 302 citations · Cited by this paper
  20. Time course of early and delayed myocardial protection induced by vagal nerve stimulation preconditioning · 2026 · Related
  21. ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4 · Hao Wu · 2023 · 251 citations · Cited by this paper
  22. Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer · Lei Ma · 2024 · 206 citations · Cited by this paper
  23. Epigenetic modifications of c-MYC: Role in cancer cell reprogramming, progression and chemoresistance · Homa Fatma · 2020 · 199 citations · Cited by this paper
  24. c-MYC mediates the crosstalk between breast cancer cells and tumor microenvironment · Fangyan Gao · 2023 · 180 citations · Cited by this paper
  25. Ischemic preconditioning preserves connexin 43 phosphorylation during sustained ischemia in pig hearts in vivo · Rainer Schulz · 2003 · 165 citations · Cited by this paper
  26. The p38 mitogen-activated protein kinase pathway—A potential target for intervention in infarction, hypertrophy, and heart failure · Michael S. Marber · 2010 · 162 citations · Cited by this paper
  27. The emerging roles of MAPK-AMPK in ferroptosis regulatory network · Xinyue Wang · 2023 · 162 citations · Cited by this paper
  28. Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial · L. Kristin Newby · 2014 · 157 citations · Cited by this paper
  29. Mitogen-activated protein kinases in the heart · Martin Christian Michel · 2001 · 135 citations · Cited by this paper
  30. C-MYC Inhibited Ferroptosis and Promoted Immune Evasion in Ovarian Cancer Cells through NCOA4 Mediated Ferritin Autophagy · Yanping Jin · 2022 · 110 citations · Cited by this paper
  31. Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy · Guiqin Huang · 2024 · 110 citations · Cited by this paper
  32. p38 Triggers Late Preconditioning Elicited by Anisomycin in Heart · Ting Cun Zhao · 2001 · 104 citations · Cited by this paper
  33. The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor · John P. Duffy · 2011 · 92 citations · Cited by this paper
  34. p38 MAP kinase is a mediator of ischemic preconditioning in pigs · Rainer Schulz · 2002 · 86 citations · Cited by this paper
  35. Attacking c-Myc: Targeted and Combined Therapies for Cancer · Huilin Huang · 2014 · 77 citations · Cited by this paper
  36. Disruption of a single copy of the p38α MAP kinase gene leads to cardioprotection against ischemia–reperfusion · Kinya Otsu · 2003 · 71 citations · Cited by this paper
  37. Specific Regulation of Noncanonical p38α Activation by Hsp90-Cdc37 Chaperone Complex in Cardiomyocyte · Asuka Ota · 2010 · 57 citations · Cited by this paper
  38. Role of GADD45A in myocardial ischemia/reperfusion through mediation of the JNK/p38 MAPK and STAT3/VEGF pathways · Yang Wang · 2022 · 51 citations · Cited by this paper
  39. Targeting the MYC Ubiquitination-Proteasome Degradation Pathway for Cancer Therapy · Xiao‐Xin Sun · 2021 · 50 citations · Cited by this paper

Source: OpenAlex (CC0)