Research map: The critical role of ceramide in mental health and psychiatric diseases

Back to the article

Papers in this map

  1. Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 · * · 2022 · 6559 citations · Cited by this paper
  2. The aftermath of alcohol misuse: Linking cellular damage, suboptimal micronutrient nutrition, and organ dysfunction · 2026 · Related
  3. Structural and functional roles of ether lipids · John M. Dean · 2017 · 697 citations · Cited by this paper
  4. A dive into the untapped potential of marine compounds in counteracting neurodegeneration · 2026 · Related
  5. Targeting a ceramide double bond improves insulin resistance and hepatic steatosis · Bhagirath Chaurasia · 2019 · 465 citations · Cited by this paper
  6. Mathematical modeling of T cell exhaustion in the tumor microenvironment · 2026 · Related
  7. Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs · Erich Gulbins · 2013 · 398 citations · Cited by this paper
  8. C26:0-lysophosphatidylcholine in X-linked adrenoleukodystrophy · 2026 · Related
  9. Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4) · Guanghu Wang · 2012 · 364 citations · Cited by this paper
  10. Circular RNA serves as an upstream regulator of the miRNA//ABCC1 axis in human cancers · 2026 · Related
  11. Ceramides in Metabolism: Key Lipotoxic Players · Bhagirath Chaurasia · 2020 · 352 citations · Cited by this paper
  12. Clinical relevance of per-particle atherogenicity of triglyceride-rich lipoproteins, Lp(a) and LDL for cardiovascular risk · 2026 · Related
  13. Sphingolipids in metabolic disease: The good, the bad, and the unknown · Christopher D. Green · 2021 · 347 citations · Cited by this paper
  14. Therapeutic potential of targeting novel signaling pathways in regulating chronic inflammation in obstructive lung disorders · 2026 · Related
  15. Metabolic Messengers: ceramides · Scott A. Summers · 2019 · 318 citations · Cited by this paper
  16. Incretin-based therapies: Effects on plasma lipids and potential mechanisms · 2026 · Related
  17. The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders · Kinga Czubowicz · 2019 · 294 citations · Cited by this paper
  18. Pharmacological activation of cGAS-STING pathway to reverse cancer drug resistance · 2026 · Related
  19. Commensal Staphylococcus epidermidis contributes to skin barrier homeostasis by generating protective ceramides · Yue Zheng · 2022 · 286 citations · Cited by this paper
  20. Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti‐PD‐1 immunotherapy efficacy in colorectal cancer liver metastasis · 2025 · Related
  21. Ceramide function in the brain: when a slight tilt is enough · Chiara Mencarelli · 2012 · 267 citations · Cited by this paper
  22. IL-10 constrains sphingolipid metabolism to limit inflammation · Autumn Gabrielle York · 2024 · 252 citations · Cited by this paper
  23. The Emerging Neurobiology of Bipolar Disorder · Paul J. Harrison · 2017 · 238 citations · Cited by this paper
  24. High Throughput Lipidomic Profiling of Schizophrenia and Bipolar Disorder Brain Tissue Reveals Alterations of Free Fatty Acids, Phosphatidylcholines, and Ceramides · Emanuel Schwarz · 2008 · 223 citations · Cited by this paper
  25. Clonal Immunoglobulin against Lysolipids in the Origin of Myeloma · Shiny Nair · 2016 · 211 citations · Cited by this paper
  26. Ceramides as Novel Disease Biomarkers · Jennifer Kurz · 2018 · 202 citations · Cited by this paper
  27. The role of ceramides in metabolic disorders: when size and localization matters · Sarah M. Turpin-Nolan · 2020 · 200 citations · Cited by this paper
  28. Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response After Myocardial Infarction · Yoav Hadas · 2020 · 173 citations · Cited by this paper
  29. Sphingolipids in cardiovascular diseases and metabolic disorders · Sonia Borodzicz-Jażdżyk · 2015 · 172 citations · Cited by this paper
  30. Super‐Resolution Imaging of the Golgi in Live Cells with a Bioorthogonal Ceramide Probe · Roman S. Erdmann · 2014 · 167 citations · Cited by this paper
  31. Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism · Xingzhong Zhang · 2019 · 159 citations · Cited by this paper
  32. Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder · Nathalie Brunkhorst-Kanaan · 2019 · 141 citations · Cited by this paper
  33. Sphingolipids in the Pathogenesis of Parkinson’s Disease and Parkinsonism · Guang Lin · 2018 · 138 citations · Cited by this paper
  34. The sphingosine kinase-1/sphingosine-1-phosphate axis in cancer: Potential target for anticancer therapy · Xiangjin Zheng · 2018 · 127 citations · Cited by this paper
  35. Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models · Liangping Su · 2023 · 127 citations · Cited by this paper
  36. Contribution of specific ceramides to obesity-associated metabolic diseases · Philipp Hammerschmidt · 2022 · 126 citations · Cited by this paper
  37. Fingolimod attenuates ceramide-induced blood–brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes · Ruben van Doorn · 2012 · 125 citations · Cited by this paper
  38. The ceramide system as a novel antidepressant target · Johannes Kornhuber · 2014 · 124 citations · Cited by this paper
  39. SCD1 is the critical signaling hub to mediate metabolic diseases: Mechanism and the development of its inhibitors · Qin Sun · 2023 · 119 citations · Cited by this paper

Source: OpenAlex (CC0)