Research map: Predictive biomarkers for immunotherapy response in renal cell carcinoma: why have they failed?

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  1. Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing · Marco Gerlinger · 2012 · 7928 citations · Cited by this paper
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  18. Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer · Ruoyan Li · 2022 · 269 citations · Cited by this paper
  19. Spatial and Temporal Heterogeneity of PD-L1 Expression and Tumor Mutational Burden in Gastroesophageal Adenocarcinoma at Baseline Diagnosis and after Chemotherapy · Katherine Ismei Zhou · 2020 · 197 citations · Cited by this paper
  20. Biomarker enrichment strategies: matching trial design to biomarker credentials · Boris Freidlin · 2013 · 177 citations · Cited by this paper
  21. Statistical and Practical Considerations for Clinical Evaluation of Predictive Biomarkers · M.-Y. C. Polley · 2013 · 155 citations · Cited by this paper
  22. Biomarker analysis from CheckMate 214: nivolumab plus ipilimumab versus sunitinib in renal cell carcinoma · Robert John Motzer · 2022 · 119 citations · Cited by this paper
  23. Correlation of genomic alterations assessed by next-generation sequencing (NGS) of tumor tissue DNA and circulating tumor DNA (ctDNA) in metastatic renal cell carcinoma (mRCC): potential clinical implications · Andrew Warren Hahn · 2017 · 63 citations · Cited by this paper
  24. Spatial and single-cell transcriptomics reveal cellular heterogeneity and a novel cancer-promoting Treg cell subset in human clear-cell renal cell carcinoma · Xiyu Song · 2025 · 44 citations · Cited by this paper
  25. Preoperative neoadjuvant targeted therapy remodels intra-tumoral heterogeneity of clear-cell renal cell carcinoma and ferroptosis inhibition induces resistance progression · Wenjin Chen · 2024 · 24 citations · Cited by this paper
  26. Multiomics in Renal Cell Carcinoma: Current Landscape and Future Directions for Precision Medicine · Filippo Gavi · 2025 · 22 citations · Cited by this paper
  27. Liquid Biopsy as a New Tool for Diagnosis and Monitoring in Renal Cell Carcinoma · Giuseppe Stefano Netti · 2025 · 16 citations · Cited by this paper
  28. Established and Emerging Biomarkers of Immunotherapy in Renal Cell Carcinoma · Yash C. Jani · 2024 · 8 citations · Cited by this paper
  29. Biomarkers for evaluating the clinical response to immune checkpoint inhibitors in renal cell carcinoma (Review) · Raquel González‐Garza · 2024 · 8 citations · Cited by this paper
  30. Renal cell carcinoma detection: a systematic review in diagnostic urinary biomarkers · Jaycey F. Kelly · 2025 · 8 citations · Cited by this paper
  31. The prognostic impact of systemic inflammation and nutritional indicators on targeted therapy for renal cell carcinoma: a systematic review and meta-analysis · Yushuang Xiao · 2026 · 8 citations · Cited by this paper
  32. From Radiomics to Radiogenomics: Decoding Renal Cell Carcinoma Biology for Precision Medicine—a narrative review · Zihan He · 2025 · 6 citations · Cited by this paper
  33. A robust ammonia metabolism gene signature identified by machine learning predicts prognosis and immunotherapy response in clear cell renal cell carcinoma · Zhilin Gong · 2026 · 3 citations · Cited by this paper
  34. Strategies to target PD-1/PD-L1 in the tumor microenvironment · Yulan Kui · 2026 · 2 citations · Cited by this paper
  35. Perioperative Immune Checkpoint Inhibitors Combined with Radical Cystectomy: A Rapid Systematic Review and Meta-analysis · Navid Roessler · 2026 · 1 citation · Cited by this paper
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