Research map: Inflammation as a pleiotropic regulator of megakaryocyte and platelet hemostatic, immune, and metabolic function

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  1. A guide to immunometabolism for immunologists · Luke A.J. O'Neill · 2016 · 3332 citations · Cited by this paper
  2. Bidirectional relationship between metabolic and thrombotic disease mechanisms · 2026 · Related
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  5. TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging · Pavel Davizon‐Castillo · 2019 · 327 citations · Cited by this paper
  6. The role of stem cell transplantation in the modern management of multiple myeloma · 2025 · Related
  7. Inducing mitophagy in diabetic platelets protects against severe oxidative stress · Seung Hee Lee · 2016 · 131 citations · Cited by this paper
  8. Aβ₁₋₄₀ Enhances Platelet Sensitivity to Thrombin via NADPH Oxidase–ROS Signaling and Integrin α IIb β ₃ Engagement · 2026 · Related
  9. Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy · Masashi Sugo · 2018 · 115 citations · Cited by this paper
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  11. An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis · Donna M. Poscablo · 2024 · 112 citations · Cited by this paper
  12. Messengers of coagulopathy: complement-carrying extracellular vesicles in SARS-CoV-2 infection · 2026 · Related
  13. Blood clot contraction: Mechanisms, pathophysiology, and disease · Rustem I. Litvinov · 2023 · 107 citations · Cited by this paper
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  15. Blood clot contraction differentially modulates internal and external fibrinolysis · Valerie J. Tutwiler · 2018 · 106 citations · Cited by this paper
  16. Roles of megakaryocytes and platelets in myeloproliferative neoplasms · 2026 · Related
  17. Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression · Colin Valet · 2022 · 104 citations · Cited by this paper
  18. Advances in the pathophysiology and treatment of anaemia in multiple myeloma · 2026 · Related
  19. Mitophagy in the pathogenesis and management of disease · Qi Wang · 2026 · 80 citations · Cited by this paper
  20. G protein-coupled receptor-mediated platelet thrombus formation · 2026 · Related
  21. The Concept of Thromboinflammation · Waltraud C. Schrottmaier · 2024 · 74 citations · Cited by this paper
  22. Aging platelets shift their hemostatic properties to inflammatory functions · Afra Anjum · 2025 · 49 citations · Cited by this paper
  23. Molecular basis of clot retraction and its role in wound healing · Alan T. Nurden · 2022 · 40 citations · Cited by this paper
  24. Human platelets display dysregulated sepsis-associated autophagy, induced by altered LC3 protein-protein interaction of the Vici-protein EPG5 · Hansjörg Schwertz · 2021 · 29 citations · Cited by this paper
  25. Rapamycin restrains platelet procoagulant responses via FKBP-mediated protection of mitochondrial integrity · Kamila M. Śledź · 2020 · 27 citations · Cited by this paper
  26. Incidence and clinical impact of bleeding events in older patients with acute venous thromboembolism · Elisa Ferrazzini · 2022 · 20 citations · Cited by this paper
  27. Platelets as central hubs of inflammation · Yan Bo · 2025 · 20 citations · Cited by this paper
  28. Risk of venous thromboembolism in patients with rheumatoid arthritis: a meta-analysis of observational studies · Zahra A. Fazal · 2024 · 19 citations · Cited by this paper
  29. Immunothrombosis versus thrombo-inflammation: platelets in cerebrovascular complications · Lexiao Li · 2024 · 19 citations · Cited by this paper
  30. Aging-related alterations in mechanistic target of rapamycin signaling promote platelet hyperreactivity and thrombosis · Irina Portier · 2024 · 19 citations · Cited by this paper
  31. mTOR regulates GPVI-mediated platelet activation · Longsheng Wang · 2021 · 17 citations · Cited by this paper
  32. Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation · Charly Kusch · 2026 · 16 citations · Cited by this paper
  33. Syntaxin-17-Dependent Mitochondrial Dynamics Is Essential for Protection against Oxidative-Stress-Induced Apoptosis · Binran Wang · 2019 · 14 citations · Cited by this paper
  34. SARS-CoV-2 infection modifies the transcriptome of the megakaryocytes in the bone marrow · Isabelle Allaeys · 2024 · 9 citations · Cited by this paper
  35. Glycoursodeoxycholic Acid Alleviates Arterial Thrombosis via Suppressing Diacylglycerol Kinases Activity in Platelet · Wenchao Yang · 2024 · 9 citations · Cited by this paper
  36. TNF-α impairs platelet function by inhibiting autophagy and disrupting metabolism via syntaxin 17 downregulation · Guadalupe Rojas-Sánchez · 2025 · 8 citations · Cited by this paper
  37. AutophagyNet: high-resolution data source for the analysis of autophagy and its regulation · Luca Csabai · 2023 · 7 citations · Cited by this paper
  38. Interleukin-1α alters megakaryocyte maturation, promotes emperipolesis, and induces a distinct proteomic profile · Robert Kolman · 2025 · 7 citations · Cited by this paper
  39. A platelet transcriptomic signature of thromboinflammation predicts cardiovascular risk · Antonia Beitzen-Heineke · 2025 · 7 citations · Cited by this paper

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