Research map: Calycosin targets the MAPK-EGR1 signaling axis to inhibit enterovirus 71 replication in cells and human colonic organoids

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  1. Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases · Gary L. Johnson · 2002 · 4338 citations · Cited by this paper
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  19. Transcriptional Regulation of EGR-1 by the Interleukin-1-JNK-MKK7-c-Jun Pathway · Elke Hoffmann · 2008 · 101 citations · Cited by this paper
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  21. Rupintrivir is a promising candidate for treating severe cases of enterovirus-71 infection: Evaluation of antiviral efficacy in a murine infection model · Xiaonan Zhang · 2013 · 98 citations · Cited by this paper
  22. Transcriptional Regulation of EGR1 by EGF and the ERK Signaling Pathway in Prostate Cancer Cells · J. Gregg · 2011 · 80 citations · Cited by this paper
  23. Calycosin alleviates cerulein-induced acute pancreatitis by inhibiting the inflammatory response and oxidative stress via the p38 MAPK and NF-κB signal pathways in mice · Ran Ma · 2018 · 77 citations · Cited by this paper
  24. In Vivo and in Vitro Antiviral Activities of Calycosin-7-O-.BETA.-D-glucopyranoside against Coxsackie Virus B3 · Haiyan Zhu · 2009 · 74 citations · Cited by this paper
  25. Activation of JNK1/2 and p38 MAPK signaling pathways promotes enterovirus 71 infection in immature dendritic cells · Hongjun Peng · 2014 · 64 citations · Cited by this paper
  26. Coxsackievirus A6 Induces Cell Cycle Arrest in G0/G1 Phase for Viral Production · Zengyan Wang · 2018 · 58 citations · Cited by this paper
  27. Activation of PI3K/Akt pathway limits JNK-mediated apoptosis during EV71 infection · Hua Zhang · 2014 · 55 citations · Cited by this paper
  28. Examining the role of EGR1 during viral infections · Caitlin M. Woodson · 2022 · 52 citations · Cited by this paper
  29. Isolation, identification and antiviral activities of metabolites of calycosin-7-O-β-d-glucopyranoside · Luying Chen · 2011 · 49 citations · Cited by this paper
  30. Early growth response-1 facilitates enterovirus 71 replication by direct binding to the viral genome RNA · Yu Song · 2015 · 48 citations · Cited by this paper
  31. Differential gene expressions of the MAPK signaling pathway in enterovirus 71-infected rhabdomyosarcoma cells · Weifeng Shi · 2013 · 47 citations · Cited by this paper
  32. Calycosin attenuates renal ischemia/reperfusion injury by suppressing NF-κB mediated inflammation via PPARγ/EGR1 pathway · Ningxin Zhang · 2022 · 47 citations · Cited by this paper
  33. Factor binding and chromatin modification in the promoter of murine Egr1 gene upon induction · Gema Tur · 2010 · 36 citations · Cited by this paper
  34. Both ERK1 and ERK2 Are Required for Enterovirus 71 (EV71) Efficient Replication · Meng Tong Zhu · 2015 · 27 citations · Cited by this paper
  35. Absorption, liver first-pass effect, pharmacokinetics and tissue distribution of calycosin-7-O-ß-d-glucopyranoside (C7G) and its major active metabolite, calycosin, following oral administration of C7G in rats by LC–MS/MS · Xiaoting Tian · 2017 · 24 citations · Cited by this paper
  36. Synthesis and biological evaluation of berberine derivatives as a new class of broad-spectrum antiviral agents against Coxsackievirus B · Qingxuan Zeng · 2019 · 24 citations · Cited by this paper
  37. Regulation of Apoptosis by Enteroviruses · Yalan Lai · 2020 · 24 citations · Cited by this paper
  38. PD169316, a specific p38 inhibitor, shows antiviral activity against Enterovirus71 · Zhe Zhang · 2017 · 22 citations · Cited by this paper
  39. Characteristics of enterovirus 71-induced cell death and genome scanning to identify viral genes involved in virus-induced cell apoptosis · Jinjin Bai · 2019 · 22 citations · Cited by this paper

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