Research map: Recent advances of CRISPR-based gene editing technologies and delivery strategies

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Papers in this map

  1. Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System · Bernd Zetsche · 2015 · 5042 citations · Cited by this paper
  2. Molecular mechanisms of phytochemicals from Zanthoxylum nitidum (Roxb.) DC. against hepatocellular carcinoma: insights from network pharmacology, molecular docking, and bioinformatics · 2026 · Related
  3. Non-viral vectors for gene-based therapy · Hao Yin · 2014 · 3132 citations · Cited by this paper
  4. Antimicrobial properties and bioactivity of zirconia-based biocomposites · 2025 · Related
  5. Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis · David H Adams · 2018 · 3047 citations · Cited by this paper
  6. Human tendon stem/progenitor cell-derived extracellular vesicle production promoted by dynamic culture · 2025 · Related
  7. Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release · Nazila Kamaly · 2016 · 3041 citations · Cited by this paper
  8. Characterization of genipin-crosslinked gelatin/PVA hydrogels and the chondroprotective influence of hydroxytyrosol: an In vitro study · 2026 · Related
  9. Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors · Andrew V. Anzalone · 2020 · 2387 citations · Cited by this paper
  10. Identification of mitophagy-related biomarkers in human rheumatoid arthritis using machine learning models · 2025 · Related
  11. Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial · Stephen R. Russell · 2017 · 1968 citations · Cited by this paper
  12. Multi-omics analysis of the potential association between ageing and rheumatoid arthritis and screening of potential therapeutic targets · 2025 · Related
  13. CRISPR-engineered T cells in patients with refractory cancer · Edward Allen Stadtmauer · 2020 · 1512 citations · Cited by this paper
  14. Cross-talk between diabetic nephropathy and bone loss: PBMCs-guided discovery of NLRP3-inflammatory signalling · 2025 · Related
  15. Programmed DNA destruction by miniature CRISPR-Cas14 enzymes · Lucas B. Harrington · 2018 · 1296 citations · Cited by this paper
  16. Exosome-mediated perturbation of the immune-bone metabolism axis: a mechanistic investigation into bone loss in a simulated microgravity environment · 2025 · Related
  17. CRISPR/Cas9 in Genome Editing and Beyond · Haifeng Wang · 2016 · 1226 citations · Cited by this paper
  18. Bio-Inspired lipid nanovesicles (iNVs) incorporating membrane proteins from healthy tendon stem cells for targeted protein restoration in tendinopathic in vitro model · 2026 · Related
  19. Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials · Feng Zhao · 2011 · 1179 citations · Cited by this paper
  20. Novel anti-rheumatic potential of Eucalrobusone C: inhibition of rheumatoid arthritis fibroblast-like synoviocytes and metabolic reprogramming · 2026 · Related
  21. The promise and challenge of therapeutic genome editing · Jennifer A. Doudna · 2020 · 1169 citations · Cited by this paper
  22. Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes · N.D. Sonawane · 2003 · 1080 citations · Cited by this paper
  23. Effect of Genome Size on AAV Vector Packaging · Zhijian Wu · 2009 · 1014 citations · Cited by this paper
  24. Theory of self-assembly of lipid bilayers and vesicles · Jacob Nissim Israelachvili · 1977 · 961 citations · Cited by this paper
  25. Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN · Christian J. Hinderer · 2018 · 833 citations · Cited by this paper
  26. In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates · Kiran Musunuru · 2021 · 806 citations · Cited by this paper
  27. Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers — Eight U.S. Locations, December 2020–March 2021 · Mark G. Thompson · 2021 · 799 citations · Cited by this paper
  28. Polymeric nanoparticles: A study on the preparation variables and characterization methods · Carina I. C. Crucho · 2017 · 691 citations · Cited by this paper
  29. Lipids and Lipid Derivatives for RNA Delivery · Yuebao Zhang · 2021 · 627 citations · Cited by this paper
  30. New CRISPR–Cas systems from uncultivated microbes · David E Burstein · 2016 · 607 citations · Cited by this paper
  31. CRISPR-CasΦ from huge phages is a hypercompact genome editor · Patrick Pausch · 2020 · 580 citations · Cited by this paper
  32. Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer · You Lü · 2020 · 555 citations · Cited by this paper
  33. Gene Therapy · Katherine A. High · 2019 · 550 citations · Cited by this paper
  34. Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA · Jason B. Miller · 2016 · 539 citations · Cited by this paper
  35. The clinical landscape for AAV gene therapies · Dmitry Kuzmin · 2021 · 522 citations · Cited by this paper
  36. Cas13d Is a Compact RNA-Targeting Type VI CRISPR Effector Positively Modulated by a WYL-Domain-Containing Accessory Protein · Winston X. Yan · 2018 · 502 citations · Cited by this paper
  37. Onasemnogene abeparvovec gene therapy for symptomatic infantile-onset spinal muscular atrophy in patients with two copies of SMN2 (STR1VE): an open-label, single-arm, multicentre, phase 3 trial · John W Day · 2021 · 501 citations · Cited by this paper
  38. Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs · Melissa P. Lokugamage · 2021 · 499 citations · Cited by this paper
  39. The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity · Dong‐Soo Im · 1990 · 473 citations · Cited by this paper

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