Research map: Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

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  1. Ferroptosis: past, present and future · Jie Li · 2020 · 4267 citations · Cited by this paper
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  11. An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment · Chih‐Hsiung Hsieh · 2021 · 269 citations · Cited by this paper
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  13. “Electron Transport Chain Interference” Strategy of Amplified Mild-Photothermal Therapy and Defect-Engineered Multi-Enzymatic Activities for Synergistic Tumor-Personalized Suppression · Shuming Dong · 2023 · 266 citations · Cited by this paper
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  15. Epidemiology of Cancer · Stephen Mark Schwartz · 2023 · 226 citations · Cited by this paper
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  17. Mitochondrial metabolism and cancer therapeutic innovation · Hongxiang Du · 2025 · 205 citations · Cited by this paper
  18. Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation (4/2026) · 2026 · Related
  19. Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery · Lei Jiang · 2021 · 194 citations · Cited by this paper
  20. Human coronary artery organ‐chip with circulating immune cells recapitulates anti‐inflammatory effect of pulsatile wall strain · 2026 · Related
  21. Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology · Jing‐Jing Yang · 2022 · 191 citations · Cited by this paper
  22. Cancer cell-mitochondria hybrid membrane coated Gboxin loaded nanomedicines for glioblastoma treatment · Yan Zou · 2023 · 181 citations · Cited by this paper
  23. Unraveling mitochondria‐targeting reactive oxygen species modulation and their implementations in cancer therapy by nanomaterials · Haibao Peng · 2023 · 176 citations · Cited by this paper
  24. Enhanced efficiency of mitochondria-targeted peptide SS-31 for acute kidney injury by pH-responsive and AKI-kidney targeted nanopolyplexes · Di Liu · 2019 · 172 citations · Cited by this paper
  25. Spatial mapping of mitochondrial networks and bioenergetics in lung cancer · Mingqi Han · 2023 · 168 citations · Cited by this paper
  26. Mitochondrial Dysfunction: Pathophysiology and Mitochondria-Targeted Drug Delivery Approaches · Tanzeel Khan · 2022 · 164 citations · Cited by this paper
  27. Mitochondria-derived cell-to-cell communication · Zahra Al Amir Dache · 2023 · 144 citations · Cited by this paper
  28. Enhancing immunotherapy with tumour-responsive nanomaterials · Stephen W. Linderman · 2025 · 143 citations · Cited by this paper
  29. A ROS‐Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro‐Angiogenesis for Efficient Treatment of Myocardial Infarction · Zhi Zheng · 2022 · 142 citations · Cited by this paper
  30. ATP Suppression by pH‐Activated Mitochondria‐Targeted Delivery of Nitric Oxide Nanoplatform for Drug Resistance Reversal and Metastasis Inhibition · Yongyan Deng · 2020 · 137 citations · Cited by this paper
  31. Addressing cancer’s grand challenges · Asher Mullard · 2020 · 134 citations · Cited by this paper
  32. The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action · Wayne A. Mitchell · 2020 · 130 citations · Cited by this paper
  33. Starvation, Ferroptosis, and Prodrug Therapy Synergistically Enabled by a Cytochrome c Oxidase like Nanozyme · Changyu Cao · 2022 · 118 citations · Cited by this paper
  34. Mitochondria-targeting Cu 3 VS 4 nanostructure with high copper ionic mobility for photothermoelectric therapy · Yushan Dong · 2023 · 104 citations · Cited by this paper
  35. Double-activation of mitochondrial permeability transition pore opening via calcium overload and reactive oxygen species for cancer therapy · Ying Zhou · 2022 · 102 citations · Cited by this paper
  36. Overcoming chemotherapy resistance via simultaneous drug-efflux circumvention and mitochondrial targeting · Minglu Zhou · 2018 · 101 citations · Cited by this paper
  37. Mitochondria-Targeted, Nanoparticle-Based Drug-Delivery Systems: Therapeutics for Mitochondrial Disorders · Sakshi Buchke · 2022 · 99 citations · Cited by this paper
  38. Recent progress in mitochondria-targeting-based nanotechnology for cancer treatment · Jingbo Qin · 2021 · 97 citations · Cited by this paper
  39. Mitochondria-Targeted Multifunctional Nanoprodrugs by Inhibiting Metabolic Reprogramming for Combating Cisplatin-Resistant Lung Cancer · Haibin Lu · 2024 · 89 citations · Cited by this paper

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