Research map: Targeting RPRD1B overcomes chemoresistance in gastric cancer by suppressing the TOPBP1-mediated DNA damage repair pathway

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  1. 5-Fluorouracil: mechanisms of action and clinical strategies · Daniel B. Longley · 2003 · 5404 citations · Cited by this paper
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  15. RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation · Zuyao Ni · 2014 · 102 citations · Cited by this paper
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  20. CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation · Yanquan Zhang · 2018 · 72 citations · Cited by this paper
  21. Targeted therapy and immunotherapy for gastric cancer: rational strategies, novel advancements, challenges, and future perspectives · Dong Luo · 2025 · 72 citations · Cited by this paper
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  23. CREPT/RPRD1B associates with Aurora B to regulate Cyclin B1 expression for accelerating the G2/M transition in gastric cancer · Lidan Ding · 2018 · 65 citations · Cited by this paper
  24. Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC · Jae-Seon Lee · 2016 · 58 citations · Cited by this paper
  25. CREPT/RPRD1B, a Recently Identified Novel Protein Highly Expressed in Tumors, Enhances the β-Catenin·TCF4 Transcriptional Activity in Response to Wnt Signaling · Yanquan Zhang · 2014 · 56 citations · Cited by this paper
  26. Targeting Chromosomal Architectural HMGB Proteins Could Be the Next Frontier in Cancer Therapy · Anirban Mukherjee · 2020 · 55 citations · Cited by this paper
  27. Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer · Marie Malier · 2021 · 37 citations · Cited by this paper
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  29. The incidences of metachronous multiple gastric cancer after various types of gastrectomy: analysis of data from a nationwide Japanese survey · Shinichi Kinami · 2020 · 33 citations · Cited by this paper
  30. The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair · Praveen L. Patidar · 2016 · 32 citations · Cited by this paper
  31. CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner · Wanli Zhai · 2021 · 24 citations · Cited by this paper
  32. Kub5-Hera RPRD1B Deficiency Promotes “BRCAness” and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers · Edward A. Motea · 2018 · 17 citations · Cited by this paper
  33. Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates · Tom Egger · 2024 · 17 citations · Cited by this paper
  34. Novel insights into the role of translesion synthesis polymerase in DNA incorporation and bypass of 5-fluorouracil in colorectal cancer · Jameson R. Averill · 2024 · 15 citations · Cited by this paper
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  37. RPRD1B's direct interaction with phosphorylated RNA polymerase II regulates polyadenylation of cell cycle genes and drives cancer progression · Rosamaria Y. Moreno · 2025 · 8 citations · Cited by this paper
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