Research map: Revisitingthe LSER Approach in the Era of MachineLearning: Insights from IAM Chromatography

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  1. Scales of solute hydrogen-bonding: their construction and application to physicochemical and biochemical processes · Michael H. Abraham · 1993 · 2137 citations · Cited by this paper
  2. A CosmeticProduct Containing PEG Derivatives InducesAnti-PEG IgM Mainly through Stimulation of the Spleen Cells in Mice · 2026 · Related
  3. Applications of Polyparameter Linear Free Energy Relationships in Environmental Chemistry · Satoshi Endo · 2014 · 315 citations · Cited by this paper
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  5. Solubility of sparingly-soluble ionizable drugs · Alex Avdeef · 2007 · 294 citations · Cited by this paper
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  7. Hydrogen bonding. Part 13. A new method for the characterisation of GLC stationary phases—the laffort data set · Michael H. Abraham · 1990 · 288 citations · Cited by this paper
  8. Development of [111In]In-CHX-A″-DTPA-αCD68for ImmunoSPECT to Image Murine Macrophages · 2026 · Related
  9. Influence of mobile phase acid–base equilibria on the chromatographic behaviour of protolytic compounds · Martı́ Rosés · 2002 · 164 citations · Cited by this paper
  10. Design, Synthesis, and Preclinical Evaluation of Novel Dimeric RM2-Based Radioligands for GRPR-Targeted Breast Cancer Imaging · 2026 · Related
  11. Retention mechanisms in micellar liquid chromatography · María José Ruiz-Ángel · 2008 · 159 citations · Cited by this paper
  12. IntegratingTumor Targeting and Half-Life Extensioninto a Dual-Surfaced Single-Domain ADAPT Protein · 2026 · Related
  13. Lipophilicity and biomimetic properties to support drug discovery · Fotios N. Tsopelas · 2017 · 117 citations · Cited by this paper
  14. Tuningthe Structural Properties of a Single-DomainAntibody Scaffold for Improved Fibroblast Activation Protein Targeting · 2026 · Related
  15. Estimation of Volume of Distribution in Humans from High Throughput HPLC-Based Measurements of Human Serum Albumin Binding and Immobilized Artificial Membrane Partitioning · Ferenc Hollósy · 2006 · 110 citations · Cited by this paper
  16. AutomatedRadiosynthesis of High-Molar-Activity 4-Borono-2-[18F]Fluorophenylalanine: Validation in Rodent Tumor Modelsand Nonhuman Primates · 2026 · Related
  17. Retention models for ionizable compounds in reversed-phase liquid chromatography · Martı́ Rosés · 2008 · 71 citations · Cited by this paper
  18. Evaluationof 161Tb-Labeled DOTA-Ibandronatefor Targeted Radionuclide Therapy in Bone Metastases · 2026 · Related
  19. Solute–solvent interactions in normal-phase liquid chromatography: a linear free-energy relationships study · Fadoua Z. Oumada · 1999 · 71 citations · Cited by this paper
  20. Predicting pHmax and Salt DisproportionationRisk for Basic Drugs · 2026 · Related
  21. Characterization of some normal-phase liquid chromatographic stationary phases based on linear solvation energy relationships · Jung Hag Park · 1998 · 64 citations · Cited by this paper
  22. Advances in immobilized artificial membrane (IAM) chromatography for novel drug discovery · Fotios N. Tsopelas · 2016 · 62 citations · Cited by this paper
  23. Unique selectivity of perfluorinated stationary phases with 2,2,2-trifluoroethanol as organic mobile phase modifier · Klara Livia Valko · 2001 · 57 citations · Cited by this paper
  24. Quantitative structure-retention relationship studies using immobilized artificial membrane chromatography I: Amended linear solvation energy relationships with the introduction of a molecular electronic factor · Jie Li · 2006 · 53 citations · Cited by this paper
  25. Lipophilic and electrostatic forces encoded in IAM-HPLC indexes of basic drugs: Their role in membrane partition and their relationships with BBB passage data · Lucia Grumetto · 2012 · 53 citations · Cited by this paper
  26. Influence of Solvent Effects on Retention of Small Molecules in Reversed-Phase Liquid Chromatography · Colin F. Poole · 2018 · 53 citations · Cited by this paper
  27. Characterization and selectivity optimization on diol, amino, and cyano normal phase columns based on linear solvation energy relationships · Jianwei Li · 1998 · 51 citations · Cited by this paper
  28. Calculation of exact Shapley values for explaining support vector machine models using the radial basis function kernel · Andrea Mastropietro · 2023 · 51 citations · Cited by this paper
  29. Learning how to use IAM chromatography for predicting permeability · Giuseppe Ermondi · 2018 · 44 citations · Cited by this paper
  30. Prediction of hERG inhibition of drug discovery compounds using biomimetic HPLC measurements · Chrysanthos Stergiopoulos · 2021 · 43 citations · Cited by this paper
  31. Characterization of hydrophilic interaction liquid chromatography retention by a linear free energy relationship. Comparison to reversed- and normal-phase retentions · Xavier Subirats · 2019 · 39 citations · Cited by this paper
  32. The role and impact of high throughput biomimetic measurements in drug discovery · Shenaz B. Bunally · 2018 · 37 citations · Cited by this paper
  33. Revisiting the application of Immobilized Artificial Membrane (IAM) chromatography to estimate in vivo distribution properties of drug discovery compounds based on the model of marketed drugs · Klara Livia Valko · 2020 · 35 citations · Cited by this paper
  34. Screening therapeutics according to their uptake across the blood-brain barrier: A high throughput method based on immobilized artificial membrane liquid chromatography-diode-array-detection coupled to electrospray-time-of-flight mass spectrometry · Giacomo Russo · 2018 · 29 citations · Cited by this paper
  35. The influence of descriptor database selection on the solvation parameter model for separation processes · Colin F. Poole · 2023 · 26 citations · Cited by this paper
  36. Linear solvation energy relationships in normal phase liquid chromatography based on retention data on silica in 2-propanol/hexane eluents · Won Jo Cheong · 1997 · 24 citations · Cited by this paper
  37. Application of linear solvation energy relationships to guide selection of polar modifiers in normal-phase liquid chromatographic separations · Jianwei Li · 1999 · 23 citations · Cited by this paper
  38. Linear free energy relationship models for the retention of partially ionized acid-base compounds in reversed-phase liquid chromatography · Sara Soriano-Meseguer · 2020 · 23 citations · Cited by this paper
  39. The use of biopartitioning micellar chromatography and immobilized artificial membrane column for in silico and in vitro determination of blood–brain barrier penetration of phenols · Katarzyna E. Stępnik · 2013 · 22 citations · Cited by this paper

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