Research map: Rethinking the concept of disease modification in an evolving Parkinson's disease treatment landscape

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Papers in this map

  1. Levodopa and the Progression of Parkinson's Disease · The Parkinson Study Group · 2004 · 1838 citations · Cited by this paper
  2. Integrating a biopsychosocial perspective: WHODAS 2.0 enhances functioning assessment in Parkinson's disease · 2026 · Related
  3. Parkinson's disease: from monogenic forms to genetic susceptibility factors · Suzanne R. Lesage · 2009 · 953 citations · Cited by this paper
  4. A case of monotherapy with intracerebroventricular anaerobic dopamine allows complete control of Parkinson's disease symptoms · 2025 · Related
  5. A Double-Blind, Delayed-Start Trial of Rasagiline in Parkinson's Disease · C. Warren Olanow · 2009 · 903 citations · Cited by this paper
  6. A review of FDG-PET biomarker analysis methods in Parkinson's disease · 2026 · Related
  7. Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study · Andrew D. Siderowf · 2023 · 746 citations · Cited by this paper
  8. Effects of deep brain stimulation on functional autonomy and quality of life in Parkinson's disease: A systematic review and meta-analysis · 2026 · Related
  9. Technology in Parkinson's disease: Challenges and opportunities · Alberto J. Espay · 2016 · 683 citations · Cited by this paper
  10. Association between age at Parkinson's disease onset and divorce: An exploratory analysis from the fox insight cohort · 2026 · Related
  11. Parkinson’s Disease: Etiology, Neuropathology, and Pathogenesis · Antonina Kouli · 2018 · 513 citations · Cited by this paper
  12. Continuous apomorphine infusion modulates cortical hyperexcitability and abnormal plasticity in Parkinson's disease · 2026 · Related
  13. Trial of Prasinezumab in Early-Stage Parkinson’s Disease · Gennaro Pagano · 2022 · 432 citations · Cited by this paper
  14. Cognition endpoints for Parkinson's disease: A roadmap for developing patient-focused assessment tools to accelerate drug development · 2026 · Related
  15. Progress towards therapies for disease modification in Parkinson's disease · Nirosen Vijiaratnam · 2021 · 431 citations · Cited by this paper
  16. Gut microbiome dysbiosis, short-chain fatty acid depletion and implications for neuroinflammation in atypical parkinsonian syndromes – a systematic review of patient cohorts · 2026 · Related
  17. Disease Modification in Parkinson's Disease: Current Approaches, Challenges, and Future Considerations · Anthony E. Lang · 2018 · 375 citations · Cited by this paper
  18. Aligning incentives for open science in biomedical research: Navigating funder and institutional perspectives · 2025 · Related
  19. Trial of Lixisenatide in Early Parkinson’s Disease · Wassilios G. Meissner · 2024 · 349 citations · Cited by this paper
  20. Prevalence and related factors of blood pressure regulation abnormalities in Parkinson's disease: Orthostatic hypotension and supine hypertension · 2025 · Related
  21. Non-motor Parkinson's: integral to motor Parkinson's, yet often neglected · Antonia Todorova · 2014 · 252 citations · Cited by this paper
  22. Does the MDS-UPDRS provide the precision to assess progression in early Parkinson’s disease? Learnings from the Parkinson’s progression marker initiative cohort · Antoine Regnault · 2019 · 246 citations · Cited by this paper
  23. The Genetics of Parkinson’s Disease and Implications for Clinical Practice · Jacob Oliver Day · 2021 · 239 citations · Cited by this paper
  24. Precision medicine for disease modification in Parkinson disease · Alberto J. Espay · 2017 · 185 citations · Cited by this paper
  25. Exenatide once a week versus placebo as a potential disease-modifying treatment for people with Parkinson's disease in the UK: a phase 3, multicentre, double-blind, parallel-group, randomised, placebo-controlled trial · Nirosen Vijiaratnam · 2025 · 162 citations · Cited by this paper
  26. GDNF and Parkinson’s Disease: Where Next? A Summary from a Recent Workshop · Roger A. Barker · 2020 · 140 citations · Cited by this paper
  27. Disease modification and biomarker development in Parkinson disease · Alberto J. Espay · 2020 · 139 citations · Cited by this paper
  28. Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson’s disease · Gennaro Pagano · 2024 · 136 citations · Cited by this paper
  29. Unmet needs in Parkinson disease: Motor and non-motor · Peter A. LeWitt · 2020 · 129 citations · Cited by this paper
  30. LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease · Danna L. Jennings · 2023 · 129 citations · Cited by this paper
  31. Parkinson’s Disease Drug Therapies in the Clinical Trial Pipeline: 2024 Update · Kevin McFarthing · 2024 · 124 citations · Cited by this paper
  32. Production of novel diagnostic radionuclides in small medical cyclotrons · Mateusz Adam Synowiecki · 2018 · 117 citations · Cited by this paper
  33. How Does Deep Brain Stimulation Change the Course of Parkinson's Disease? · Philipp Mahlknecht · 2022 · 113 citations · Cited by this paper
  34. People with Parkinson’s Disease: What Symptoms Do They Most Want to Improve and How Does This Change with Disease Duration? · Rebecca J. Port · 2021 · 106 citations · Cited by this paper
  35. Artificial Intelligence-Based Voice Assessment of Patients with Parkinson’s Disease Off and On Treatment: Machine vs. Deep-Learning Comparison · Giovanni Costantini · 2023 · 99 citations · Cited by this paper
  36. Modifying the progression of Alzheimer's and Parkinson's disease with deep brain stimulation · Martin Jakobs · 2019 · 74 citations · Cited by this paper
  37. Prodromal Parkinson's disease: hype or hope for disease-modification trials? · Philipp Mahlknecht · 2022 · 73 citations · Cited by this paper
  38. Using a smartwatch and smartphone to assess early Parkinson’s disease in the WATCH-PD study over 12 months · Jamie Adams · 2024 · 68 citations · Cited by this paper
  39. A Survey of Parkinson's Disease Patients: Most Bothersome Symptoms and Coping Preferences · Lisa A. Uebelacker · 2014 · 67 citations · Cited by this paper

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