Research map: Exosome-mediated siRNA delivery in cancer: Loading strategies, targeting approaches, and therapeutic outcomes

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Papers in this map

  1. Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids · Clotilde Théry · 2006 · 5882 citations · Cited by this paper
  2. The effect of Fe3O4 biosynthesized through the green synthesis of Silybum marianum and HA in the targeted delivery of 5-Fluorouracil to HCT116 cell line · 2025 · Related
  3. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes · Lydia Alvarez‐Erviti · 2011 · 4982 citations · Cited by this paper
  4. Tableting of nanoparticle-based formulations for oral delivery: Enhancing biopharmaceutical performance · 2026 · Related
  5. Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism · Haoqiang Ying · 2012 · 2105 citations · Cited by this paper
  6. Advances in nanostructured drug delivery systems for cardiovascular therapeutics · 2025 · Related
  7. Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications · Yi Zhang · 2020 · 1329 citations · Cited by this paper
  8. Poly (lactic-co-glycolic acid) nanoplatforms for triple-negative breast cancer: current progress, advances, and future outlook · 2026 · Related
  9. The role of lipid components in lipid nanoparticles for vaccines and gene therapy · Camilla Hald Albertsen · 2022 · 1189 citations · Cited by this paper
  10. Eugenol mitigates schizophrenia-like behavioral deficits, oxidative stress, apoptosis, neuroinflammation, and cholinergic dysfunction in ketamine-induced mice · 2026 · Related
  11. Bovine milk-derived exosomes for drug delivery · Radha Munagala · 2015 · 956 citations · Cited by this paper
  12. Plant-derived exosome-like nanovesicles as programmable bio-organic excipients: a next-generation platform for precision and immuno-silent drug delivery · 2026 · Related
  13. Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth · Hongqi Xin · 2012 · 920 citations · Cited by this paper
  14. Deep fused explainable neural architecture for the automatic recognition of therapeutic medicinal plants · 2026 · Related
  15. Nanomedicine in cancer therapy · Dahua Fan · 2023 · 861 citations · Cited by this paper
  16. Novel 3,3′-diindolylmethane derivatives as multi-pathway modulators: targeting estrogen-dependent and independent breast cancer carcinogenesis · 2026 · Related
  17. Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer · Senlin Zhao · 2020 · 825 citations · Cited by this paper
  18. Co-delivery of SN38 and rapamycin albumin bound nanoparticles against breast Cancer · 2025 · Related
  19. Generation and testing of clinical-grade exosomes for pancreatic cancer · Mayela Carolina Mendt · 2018 · 797 citations · Cited by this paper
  20. Exosome engineering for targeted therapy of brain-infecting pathogens: molecular tools, delivery platforms, and translational advances · 2025 · Related
  21. Biodistribution and delivery efficiency of unmodified tumor-derived exosomes · Tyson Smyth · 2014 · 747 citations · Cited by this paper
  22. Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer · Qing-Fang Han · 2022 · 669 citations · Cited by this paper
  23. The Machinery of Exosomes: Biogenesis, Release, and Uptake · Sofia V. Krylova · 2023 · 653 citations · Cited by this paper
  24. Current hurdles to the translation of nanomedicines from bench to the clinic · Snežana Đorđević · 2021 · 644 citations · Cited by this paper
  25. Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming · Samantha M. Morrissey · 2021 · 631 citations · Cited by this paper
  26. Exosome-mediated delivery of siRNA in vitro and in vivo · Samir EL Andaloussi · 2012 · 621 citations · Cited by this paper
  27. Exosome Processing and Characterization Approaches for Research and Technology Development · James J. Lai · 2022 · 621 citations · Cited by this paper
  28. A review on exosomes application in clinical trials: perspective, questions, and challenges · Jafar Rezaie · 2022 · 614 citations · Cited by this paper
  29. Systemic exosomal siRNA delivery reduced alpha‐synuclein aggregates in brains of transgenic mice · Jonathan M. Cooper · 2014 · 516 citations · Cited by this paper
  30. RAB31 marks and controls an ESCRT-independent exosome pathway · Denghui Wei · 2020 · 506 citations · Cited by this paper
  31. Exosomes are natural carriers of exogenous siRNA to human cells in vitro · Tatiana A. Shtam · 2013 · 501 citations · Cited by this paper
  32. M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages · Gowri Rangaswamy Gunassekaran · 2021 · 485 citations · Cited by this paper
  33. Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis · Liuwan Zhao · 2019 · 447 citations · Cited by this paper
  34. Liposomal siRNA nanocarriers for cancer therapy · Bülent Özpolat · 2014 · 445 citations · Cited by this paper
  35. Exosome-encapsulated miRNAs contribute to CXCL12/CXCR4-induced liver metastasis of colorectal cancer by enhancing M2 polarization of macrophages · Dong Wang · 2020 · 429 citations · Cited by this paper
  36. Exosomes in the tumor microenvironment as mediators of cancer therapy resistance · Irene Li · 2019 · 417 citations · Cited by this paper
  37. Plant‐derived extracellular vesicles: Recent advancements and current challenges on their use for biomedical applications · Meredith Qikai Lian · 2022 · 387 citations · Cited by this paper
  38. Cancer associated-fibroblast-derived exosomes in cancer progression · Chao Li · 2021 · 348 citations · Cited by this paper
  39. Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug · Xiaoyang Xu · 2013 · 340 citations · Cited by this paper

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