Research map: The Central Role of HLA Class II-Restricted Helper Neoantigen Vaccines in Cancer Immunotherapy

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  1. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade · Nicholas McGranahan · 2016 · 3184 citations · Cited by this paper
  2. Bridging clinical gaps in personalized cancer neoantigen vaccines · 2026 · Related
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  9. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens · Matthew M. Gubin · 2014 · 2013 citations · Cited by this paper
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  11. Defining ‘T cell exhaustion’ · Christian U. Blank · 2019 · 1675 citations · Cited by this paper
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  13. Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial · Derin B. Keskin · 2018 · 1481 citations · Cited by this paper
  14. Ex Vivo Line-Field Confocal Optical Coherence Tomography and Ex Vivo Fusion Confocal Microscopy for Lateral-Margin Assessment of Basal Cell Carcinoma in Correlation with Histopathology: A Prospective Pilot Diagnostic-Accuracy Study · 2026 · Related
  15. Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation · Karthik Dhatchinamoorthy · 2021 · 1107 citations · Cited by this paper
  16. Burden, Trends, and Future Projections of Multiple Myeloma in China from 1990 to 2023 · 2026 · Related
  17. Targeting neoantigens to augment antitumour immunity · Mark M. Yarchoan · 2017 · 1055 citations · Cited by this paper
  18. PTEN Protein Loss in Diagnostic Prostate Biopsies Is Associated with Gleason Score Upgrading in Radical Prostatectomy · 2026 · Related
  19. MHC-II neoantigens shape tumour immunity and response to immunotherapy · Elise Alspach · 2019 · 896 citations · Cited by this paper
  20. Predictive Biomarkers of Systemic Therapy Response in Cutaneous Melanoma · 2026 · Related
  21. Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms · Rong En Tay · 2020 · 871 citations · Cited by this paper
  22. The multifaceted role of CD4+ T cells in CD8+ T cell memory · Brian J. Laidlaw · 2016 · 679 citations · Cited by this paper
  23. Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma · Zhuting Hu · 2021 · 548 citations · Cited by this paper
  24. Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses · Can Cui · 2021 · 501 citations · Cited by this paper
  25. CD4+ T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness · Tomasz Ahrends · 2017 · 429 citations · Cited by this paper
  26. Antigen presentation in cancer — mechanisms and clinical implications for immunotherapy · Kailin Yang · 2023 · 317 citations · Cited by this paper
  27. Re-Emergence of Dendritic Cell Vaccines for Cancer Treatment · Mansi Saxena · 2018 · 308 citations · Cited by this paper
  28. Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer · Zhenyu Ding · 2021 · 278 citations · Cited by this paper
  29. Challenges in developing personalized neoantigen cancer vaccines · Peter D. Katsikis · 2023 · 256 citations · Cited by this paper
  30. A unique tumor antigen produced by a single amino acid substitution · Paul A. Monach · 1995 · 241 citations · Cited by this paper
  31. Cancer Vaccine Therapeutics: Limitations and Effectiveness—A Literature Review · Mariusz Kaczmarek · 2023 · 238 citations · Cited by this paper
  32. Neoantigen-targeted CD8+ T cell responses with PD-1 blockade therapy · Cristina Puig-Saus · 2023 · 214 citations · Cited by this paper
  33. Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function · Joshua R. Veatch · 2022 · 154 citations · Cited by this paper
  34. A comprehensive proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapy · Florian Huber · 2024 · 121 citations · Cited by this paper
  35. Trial watch: Dendritic cell-based anticancer immunotherapy · Abhishek Dinkarnath Garg · 2017 · 118 citations · Cited by this paper
  36. T Cells Associated with Tumor Regression Recognize Frameshifted Products of the CDKN2A Tumor Suppressor Gene Locus and a Mutated HLA Class I Gene Product · Jianping Huang · 2004 · 116 citations · Cited by this paper
  37. Regulatory T cells in the tumour microenvironment · Charlotte J. Imianowski · 2025 · 107 citations · Cited by this paper
  38. Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy · Hussein Sultan · 2024 · 103 citations · Cited by this paper
  39. CD4+ helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment · Xin Lei · 2023 · 92 citations · Cited by this paper

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