Research map: Liraglutide reprograms vascular smooth muscle cell metabolism to suppress extracellular matrix remodeling in diabetic atherosclerosis

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  1. mTOR Signaling in Growth Control and Disease · Mathieu Laplante · 2012 · 8686 citations · Cited by this paper
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  16. Improved prognosis prediction of all‐cause mortality and cardiovascular events by combined assessment of both ankle‐brachial index and brachial‐ankle pulse wave velocity in individuals with diabetes: The Kyushu prevention study for atherosclerosis, a prospective, multicenter survey · 2026 · Related
  17. The impact of insulin resistance on the kidney and vasculature · Ferruh Artunç · 2016 · 481 citations · Cited by this paper
  18. The miR ‐145‐5p/ NRF2 / SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell injury in diabetic nephropathy · 2026 · Related
  19. The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis · Julian J. Lum · 2007 · 433 citations · Cited by this paper
  20. USP30 inhibits wound healing in diabetic foot ulcers by promoting TRAF6 ‐induced ferroptosis and angiogenesis inhibition · 2026 · Related
  21. Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis · Gabriel F. Alencar · 2020 · 420 citations · Cited by this paper
  22. Endothelial GLP-1 (Glucagon-Like Peptide-1) Receptor Mediates Cardiovascular Protection by Liraglutide In Mice With Experimental Arterial Hypertension · Johanna Helmstädter · 2019 · 274 citations · Cited by this paper
  23. Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis · Mandy O. J. Grootaert · 2015 · 269 citations · Cited by this paper
  24. Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells · Battsetseg Batchuluun · 2013 · 160 citations · Cited by this paper
  25. GLP-1 receptor agonists and reduction of cardiometabolic risk: Potential underlying mechanisms · Manfredi Rizzo · 2018 · 151 citations · Cited by this paper
  26. Liraglutide, a GLP-1 receptor agonist, inhibits vascular smooth muscle cell proliferation by enhancing AMP-activated protein kinase and cell cycle regulation, and delays atherosclerosis in ApoE deficient mice · Teruo Jojima · 2017 · 107 citations · Cited by this paper
  27. Liraglutide attenuates high glucose-induced abnormal cell migration, proliferation, and apoptosis of vascular smooth muscle cells by activating the GLP-1 receptor, and inhibiting ERK1/2 and PI3K/Akt signaling pathways · Lili Shi · 2015 · 90 citations · Cited by this paper
  28. Cholesterol and HIF-1α: Dangerous Liaisons in Atherosclerosis · Charles W. Thomas · 2022 · 54 citations · Cited by this paper
  29. Metformin inhibits high glucose-induced smooth muscle cell proliferation and migration · Dongming Zhou · 2020 · 51 citations · Cited by this paper
  30. Glycolysis and de novo fatty acid synthesis cooperatively regulate pathological vascular smooth muscle cell phenotypic switching and neointimal hyperplasia · Kaixiang Cao · 2023 · 43 citations · Cited by this paper
  31. Bioenergetic profile of human coronary artery smooth muscle cells and effect of metabolic intervention · Mingming Yang · 2017 · 37 citations · Cited by this paper
  32. Antiatherogenic effects of liraglutide in hyperglycemic apolipoprotein E-null mice via AMP-activated protein kinase-independent mechanisms · Masakazu Koshibu · 2019 · 28 citations · Cited by this paper
  33. High Glucose Levels Promote Switch to Synthetic Vascular Smooth Muscle Cells via Lactate/GPR81 · Jing Yang · 2024 · 28 citations · Cited by this paper
  34. Metformin Directly Binds to MMP-9 to Improve Plaque Stability · Xianda Chen · 2023 · 16 citations · Cited by this paper

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