Research map: Inflammation-Induced Claudin-2 Up-Regulation Limits Pancreatitis Development by Enhancing Pancreatic Ductal Transport

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  1. Occludin: a novel integral membrane protein localizing at tight junctions. · Mikio Furuse · 1993 · 2578 citations · Cited by this paper
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  13. Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells · Salah Amasheh · 2002 · 818 citations · Cited by this paper
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  17. Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis · Heinz Schmitz* · 1999 · 613 citations · Cited by this paper
  18. Interleukin-6 (IL-6) Regulates Claudin-2 Expression and Tight Junction Permeability in Intestinal Epithelium · Takuya Suzuki · 2011 · 536 citations · Cited by this paper
  19. Chronic pancreatitis · Georg Beyer · 2020 · 507 citations · Cited by this paper
  20. Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells · Shyam Babu Prasad · 2005 · 494 citations · Cited by this paper
  21. Diagnosis and Management of Chronic Pancreatitis · Vikesh K. Singh · 2019 · 482 citations · Cited by this paper
  22. Ionic Conductances of Extracellular Shunt Pathway in Rabbit Ileum · Raymond A. Frizzell · 1972 · 416 citations · Cited by this paper
  23. Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis · Jing Xue · 2015 · 366 citations · Cited by this paper
  24. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis · David Clement Whitcomb · 2012 · 361 citations · Cited by this paper
  25. Molecular Basis for Cation Selectivity in Claudin-2–based Paracellular Pores: Identification of an Electrostatic Interaction Site · Alan S.L. Yu · 2008 · 316 citations · Cited by this paper
  26. Claudin-2–deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules · Shigeaki Muto · 2010 · 301 citations · Cited by this paper
  27. Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity · Christopher R. Weber · 2010 · 299 citations · Cited by this paper
  28. Claudin-1 contributes to the epithelial barrier function in MDCK cells · Tetsuichiro Inai · 1999 · 285 citations · Cited by this paper
  29. IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance · Pei-Yun Tsai · 2017 · 274 citations · Cited by this paper
  30. Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux · Mary M. Buschmann · 2013 · 192 citations · Cited by this paper
  31. Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3 − secretion: relevance to cystic fibrosis · Youxue Wang · 2006 · 165 citations · Cited by this paper
  32. TNFα up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling · Joachim Mankertz · 2009 · 163 citations · Cited by this paper
  33. Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis · Woody Denham · 1997 · 158 citations · Cited by this paper
  34. OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics · Jonathan M. Matthews · 2022 · 154 citations · Cited by this paper
  35. Chronic Pancreatitis · Santhi Swaroop Vege · 2022 · 151 citations · Cited by this paper
  36. Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice · Preeti Raju · 2020 · 134 citations · Cited by this paper
  37. IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression · Yaya Wang · 2017 · 127 citations · Cited by this paper
  38. Polymorphisms at PRSS1–PRSS2 and CLDN2–MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study · Monique H. M. Derikx · 2014 · 125 citations · Cited by this paper
  39. Claudin‐2‐mediated cation and water transport share a common pore · Rita Rosenthal · 2016 · 125 citations · Cited by this paper

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