Research map: Lapatinib Induces Ferroptosis in Cardiomyocytes by Regulating ATF4/GPX4

Back to the article

Papers in this map

  1. Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death · Scott J. Dixon · 2012 · 19067 citations · Cited by this paper
  2. Cardiovascular Toxicity in Cancer Therapy: Potential Mechanisms of Ferroptosis and Treatment Strategies · Jiani Dai · 2026 · Cites this paper
  3. Non-canonical PPARα Agonism by Arjunolic Acid Mitigates Cardiomyocyte PANoptosis Through a Novel PPARα/CRYAB/IKKα Axis During Pathological Cardiac Hypertrophy · 2026 · Related
  4. An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress · Heather P. Harding · 2003 · 3409 citations · Cited by this paper
  5. Interpretable Machine Learning in Heavy Metal-Associated Cardiovascular and Metabolic Disease: A Review of Current Methodologies, Toxicological Insights, and Clinical Implications · 2026 · Related
  6. 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines · José Luis Zamorano · 2016 · 2585 citations · Cited by this paper
  7. Drug-Induced Noninfectious Myocarditis/Pericarditis: A Real-World Pharmacovigilance Study Using the FAERS Database · 2026 · Related
  8. Ferroptosis as a target for protection against cardiomyopathy · Xuexian Fang · 2019 · 2208 citations · Cited by this paper
  9. Methyltransferase METTL1 Upregulates USF2 in a m7G-Dependent Manner to Accelerate Septic Cardiomyopathy by Inactivating PINK1/Parkin-Mediated Mitophagy · 2026 · Related
  10. Ferroptosis: mechanisms and links with diseases · Hong-Fa Yan · 2021 · 1491 citations · Cited by this paper
  11. Tnxb Alleviates Myocardial Ischemia-Reperfusion Injury Through Facilitating Akt-Dependent Endothelial Cell Survival and Angiogenesis in Mice · 2026 · Related
  12. A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib) · Edgar R. Wood · 2004 · 1137 citations · Cited by this paper
  13. GLI1 Promotes Hypoxia Induced Pyroptosis of PASMCs and Aggravates Pulmonary Arterial Hypertension in Rats by Upregulating HDAC1 Expression · 2026 · Related
  14. Regulated cell death pathways in doxorubicin-induced cardiotoxicity · Effimia Christidi · 2021 · 693 citations · Cited by this paper
  15. E-cigarette Aerosol Containing Nicotine Increases Aortic Stiffness in Young Mice · 2026 · Related
  16. Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells · Shumei Ma · 2016 · 637 citations · Cited by this paper
  17. Bioinformatics Analysis of Molecular Interactions between Endoplasmic Reticulum Stress and Ferroptosis under Stress Exposure · 2023 · Related
  18. Molecular Changes in Tamoxifen-Resistant Breast Cancer: Relationship Between Estrogen Receptor, HER-2, and p38 Mitogen-Activated Protein Kinase · M. Carolina Gutierrez · 2005 · 494 citations · Cited by this paper
  19. Nanomedicine And Nanotheranostics: Special Focus on Imaging of Anticancer Drugs Induced Cardiac Toxicity · 2024 · Related
  20. ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis · Feng He · 2023 · 402 citations · Cited by this paper
  21. Cardiotoxicity induced by tyrosine kinase inhibitors · George S. Orphanos · 2009 · 289 citations · Cited by this paper
  22. Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity · Wanjun Ma · 2020 · 172 citations · Cited by this paper
  23. Serum Starvation Induced Cell Cycle Synchronization Facilitates Human Somatic Cells Reprogramming · Mengfei Chen · 2012 · 153 citations · Cited by this paper
  24. Lapatinib induces mitochondrial dysfunction to enhance oxidative stress and ferroptosis in doxorubicin-induced cardiomyocytes via inhibition of PI3K/AKT signaling pathway · Lei Sun · 2021 · 127 citations · Cited by this paper
  25. miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity · Jianan Pan · 2019 · 126 citations · Cited by this paper
  26. Lapatinib · Minna Voigtlaender · 2018 · 125 citations · Cited by this paper
  27. Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy · Meilin Chen · 2021 · 116 citations · Cited by this paper
  28. Serum HER‐2/neu conversion to positive at the time of disease progression in patients with breast carcinoma on hormone therapy · Allan Lipton · 2005 · 99 citations · Cited by this paper
  29. Activating transcription factor 4 regulates osteoclast differentiation in mice · Huiling Cao · 2010 · 99 citations · Cited by this paper
  30. Cardiotoxicity of Anticancer Therapeutics · Jerry Dong · 2018 · 96 citations · Cited by this paper
  31. Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2 · Gui-e Xu · 2024 · 77 citations · Cited by this paper
  32. Lapatinib inhibits receptor phosphorylation and cell growth and enhances antibody‐dependent cellular cytotoxicity of EGFR‐ and HER2‐overexpressing esophageal cancer cell lines · Kousaku Mimura · 2011 · 70 citations · Cited by this paper
  33. ATF4 protects against sorafenib-induced cardiotoxicity by suppressing ferroptosis · Hui Jiang · 2022 · 60 citations · Cited by this paper
  34. The HER2 inhibitor lapatinib potentiates doxorubicin-induced cardiotoxicity through iNOS signaling · Wan-Tseng Hsu · 2018 · 58 citations · Cited by this paper
  35. Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells · Masashi Masuda · 2016 · 57 citations · Cited by this paper
  36. Phase I Pharmacokinetic Study of the Safety and Tolerability of Lapatinib (GW572016) in Combination with Oxaliplatin/Fluorouracil/Leucovorin (FOLFOX4) in Patients with Solid Tumors · Wandena S. Siegel-Lakhai · 2007 · 49 citations · Cited by this paper
  37. Lapatinib: a tyrosine kinase inhibitor with a clinical role in breast cancer · Abhik Mukherjee · 2007 · 46 citations · Cited by this paper
  38. Conserved signaling mechanisms in Drosophila heart development · Shaad M. Ahmad · 2017 · 46 citations · Cited by this paper
  39. ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1 adipocytes differentiation · Hu Chen · 2016 · 42 citations · Cited by this paper

Source: OpenAlex (CC0)