Research map: Our understanding of the interactions between immune cells and beta cells in the pancreas: autoimmune mechanisms leading to type 1 diabetes

Back to the article

Papers in this map

  1. Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1 · Daniel J. Drucker · 2018 · 2131 citations · Cited by this paper
  2. The role of immunosenescence and chronic medical conditions on the immune response to respiratory syncytial virus in older individuals · 2026 · Related
  3. Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes · Miriam Cnop · 2005 · 1500 citations · Cited by this paper
  4. Harnessing the immune system in lung cancer: emerging role of the microbiome · 2026 · Related
  5. The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus · Decio Laks Eizirik · 2007 · 1178 citations · Cited by this paper
  6. Organ damage in systemic sclerosis: linking immune activation, vasculopathy, and fibrosis to precision treatment · 2026 · Related
  7. Endoplasmic reticulum stress signalling – from basic mechanisms to clinical applications · Aitor Almanza · 2018 · 1054 citations · Cited by this paper
  8. Beyond the binary: understanding inflammatory bowel disease in the context of HIV-induced immunodeficiency · 2026 · Related
  9. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice · Maki Nakayama · 2005 · 762 citations · Cited by this paper
  10. Inflammatory bowel disease and primary sclerosing cholangitis: immunological links and clinical outlook · 2026 · Related
  11. Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?) · Bart O. Roep · 2020 · 641 citations · Cited by this paper
  12. Keratoconus: an ocular manifestation of systemic immune dysregulation? · 2026 · Related
  13. What causes the insulin resistance underlying obesity? · Olga T. Hardy · 2012 · 565 citations · Cited by this paper
  14. Targeting the cytokine storm: new therapies in the treatment of pediatric hemophagocytic lymphohistiocytosis · 2026 · Related
  15. GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes · Johnny Ludvigsson · 2008 · 520 citations · Cited by this paper
  16. Reconsidering the interpretation of polyautoimmunity in chronic immune-mediated neuropathies: association, misclassification, and clinical implications · 2026 · Related
  17. GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects · Xin Zhao · 2021 · 456 citations · Cited by this paper
  18. Malignancies in the context of Inborn errors of immunity: an immunologist’s view · 2026 · Related
  19. The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients · Piero Marchetti · 2007 · 417 citations · Cited by this paper
  20. Sarcoid-like reactions: a comprehensive review of granulomatous diseases mimicking sarcoidosis · 2026 · Related
  21. Experimental Autoimmune Encephalomyelitis in the Mouse · Stephen D. Miller · 2007 · 402 citations · Cited by this paper
  22. Endoplasmic reticulum stress and pancreatic β-cell death · Sonya G. Fonseca · 2011 · 373 citations · Cited by this paper
  23. Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model · Sarah A. Tersey · 2012 · 365 citations · Cited by this paper
  24. Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes · Peter J. Thompson · 2019 · 359 citations · Cited by this paper
  25. Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes · Feyza Engin · 2013 · 325 citations · Cited by this paper
  26. Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes · Lars Krogvold · 2014 · 321 citations · Cited by this paper
  27. Obesity, increased linear growth, and risk of type 1 diabetes in children. · Elina Hyppönen · 2000 · 286 citations · Cited by this paper
  28. Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors · Slobodan Čulina · 2018 · 274 citations · Cited by this paper
  29. Type 1 diabetes as a relapsing–remitting disease? · Matthias von Herrath · 2007 · 273 citations · Cited by this paper
  30. Teplizumab and β-Cell Function in Newly Diagnosed Type 1 Diabetes · Eleanor L. Ramos · 2023 · 259 citations · Cited by this paper
  31. Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes · Teresa Rodriguez Calvo · 2014 · 243 citations · Cited by this paper
  32. Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms · Flora Brozzi · 2015 · 242 citations · Cited by this paper
  33. Chapter 16 Insulin Granule Biogenesis, Trafficking and Exocytosis · June Chunqiu Hou · 2009 · 217 citations · Cited by this paper
  34. Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial · Matthias von Herrath · 2021 · 186 citations · Cited by this paper
  35. Effect of Verapamil on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 Diabetes · Gregory P. Forlenza · 2023 · 174 citations · Cited by this paper
  36. ER Stress in Pancreatic β Cells: The Thin Red Line Between Adaptation and Failure · Decio Laks Eizirik · 2010 · 164 citations · Cited by this paper
  37. Euglycemic diabetic ketoacidosis in the era of SGLT-2 inhibitors · Erica Chow · 2023 · 163 citations · Cited by this paper
  38. Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine · Bart O. Roep · 2018 · 128 citations · Cited by this paper
  39. GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration · Courtney A. Ackeifi · 2020 · 126 citations · Cited by this paper

Source: OpenAlex (CC0)