Research map: Accurate Measurement of Serum Free Testosterone Levels via Liquid Chromatography‒Tandem Mass Spectrometry (LC‒MS/MS) has Predictive Value in the Diagnosis of Polycystic Ovary Syndrome and Associated Metabolic Disorders

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  1. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome · 2004 · 9138 citations · Cited by this paper
  2. Mitochondrial Function and Dysfunction in Female Fertility: Biological Mechanisms, Genetic Determinants, and Therapeutic Opportunities – A Review · 2026 · Related
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  6. A Review of microRNAs in the Post-transcriptional Regulation and its Clinical Manifestation in the Polycystic Ovary Syndrome · 2026 · Related
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  9. American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1 · Neil F. Goodman · 2015 · 633 citations · Cited by this paper
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  11. Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies · Miguel Angel Sanchez-Garrido · 2020 · 555 citations · Cited by this paper
  12. Decoding Infertility: the Epigenetic Influence of HDACs on Reproductive Function · 2026 · Related
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  15. A Reappraisal of Testosterone’s Binding in Circulation: Physiological and Clinical Implications · Anna L Goldman · 2017 · 416 citations · Cited by this paper
  16. Betaine Alleviates Favipiravir-induced Ovarian and Uterine Toxicity by Regulating Oxidative, Inflammatory, Cellular Death, Steroidogenic, Hormonal, and Histopathological Changes · 2026 · Related
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  19. Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice · Daojuan Wang · 2020 · 252 citations · Cited by this paper
  20. Hormone responses to buserelin in polycystic ovary syndrome and in eumenorrheic women with hyperandrogenism/hyperandrogenemia, and the relationship of these responses with insulin resistance · 2025 · Related
  21. Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome · Helena Jane Teede · 2023 · 230 citations · Cited by this paper
  22. AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome · Michael O’Reilly · 2017 · 213 citations · Cited by this paper
  23. Polycystic ovary syndrome as a metabolic disease · Nafiye Helvacı · 2024 · 175 citations · Cited by this paper
  24. Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis · Michaël R. Laurent · 2016 · 173 citations · Cited by this paper
  25. Effects of Androgen Excess-Related Metabolic Disturbances on Granulosa Cell Function and Follicular Development · Baoying Liao · 2022 · 160 citations · Cited by this paper
  26. Recent Advances in Acne Pathogenesis: Implications for Therapy · Shinjita Das · 2014 · 155 citations · Cited by this paper
  27. Defining hirsutism in Chinese women: a cross-sectional study · Xiaomiao Zhao · 2011 · 149 citations · Cited by this paper
  28. Effectiveness of conventional, low-dose and intermittent oral isotretinoin in the treatment of acne: a randomized, controlled comparative study · Joon Woo Lee · 2010 · 128 citations · Cited by this paper
  29. Changes in the prevalence of polycystic ovary syndrome in China over the past decade · Rui Jie Yang · 2022 · 112 citations · Cited by this paper
  30. Enlarged adipocytes in subcutaneous adipose tissue associated to hyperandrogenism and visceral adipose tissue volume in women with polycystic ovary syndrome · Bárbara Echiburú · 2017 · 88 citations · Cited by this paper
  31. Cutaneous Findings and Systemic Associations in Women With Polycystic Ovary Syndrome · Timothy H. Schmidt · 2015 · 86 citations · Cited by this paper
  32. New biomarkers for diagnosis and management of polycystic ovary syndrome · Sidika E. Karakas · 2017 · 79 citations · Cited by this paper
  33. Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids · Dessie Salilew‐Wondim · 2015 · 78 citations · Cited by this paper
  34. Specificity and predictive value of circulating testosterone assessed by tandem mass spectrometry for the diagnosis of polycystic ovary syndrome by the National Institutes of Health 1990 criteria · Wael Antoine Salameh · 2014 · 67 citations · Cited by this paper
  35. Testosterone, free testosterone, and free androgen index in women: Reference intervals, biological variation, and diagnostic value in polycystic ovary syndrome · Hong N. Bui · 2015 · 65 citations · Cited by this paper
  36. Increased androgen levels in rats impair glucose-stimulated insulin secretion through disruption of pancreatic beta cell mitochondrial function · Hongdong Wang · 2015 · 60 citations · Cited by this paper
  37. Association between biochemical hyperandrogenism parameters and Ferriman‐Gallwey score in patients with polycystic ovary syndrome: A systematic review and meta‐regression analysis · Mina Amiri · 2017 · 58 citations · Cited by this paper
  38. Oxidative stress promotes hyperandrogenism by reducing sex hormone-binding globulin in polycystic ovary syndrome · Yuan Sun · 2021 · 53 citations · Cited by this paper
  39. Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring · Maria Manti · 2019 · 47 citations · Cited by this paper

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