Research map: Frustra laborare ? Methodological inefficiencies and epistemic limits in toxicological testing
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Papers in this map
Raise standards for preclinical cancer research
· C. Glenn Begley · 2012 · 2972 citations · Cited by this paper
Cytotoxicity across OECD methods is not a single endpoint: context-dependent roles, variability and implications for decision-making
· Tizia Thoma · 2026 · Cites this paper
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Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection
· Bruce N. Ames · 1973 · 2294 citations · Cited by this paper
Combinatorial induction with valproic acid and fibroblast growth factor-9 enhances neural differentiation and cell fate commitment in adipose tissue-derived mesenchymal stem cells
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· George Gaylord Simpson · 1953 · 2043 citations · Cited by this paper
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Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease
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· Thomas Härtung · 2009 · 665 citations · Cited by this paper
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Ecological Causes of Adaptive Radiation
· Dolph Schluter · 1996 · 483 citations · Cited by this paper
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· EFSA Scientific Committee · 2011 · 479 citations · Cited by this paper
Assessing Experimental Uncertainty in Defined Approaches: Borderline Ranges for In Chemico and In Vitro Skin Sensitization Methods Determined from Ring Trial Data
· 2021 · Related
Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment
· Barbara A. Wetmore · 2011 · 418 citations · Cited by this paper
The Use of Toxicokinetic Information for Setting Concentrations of In Vitro Toxicity Tests and for Interpreting Their Results: A Proposed Workflow
· 2024 · Related
New approach methodologies in human regulatory toxicology – Not if, but how and when!
· Sebastian Schmeisser · 2023 · 379 citations · Cited by this paper
Charting a new path, replacing animals in biomedical research
· 2025 · Related
Integrated Model of Chemical Perturbations of a Biological Pathway Using 18In VitroHigh-Throughput Screening Assays for the Estrogen Receptor
· Richard Judson · 2015 · 313 citations · Cited by this paper
Assessment of the Robustness and Accuracy of the Deiodinase 1 Sandell–Kolthoff Assay: A Comparative Analysis
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A framework for establishing scientific confidence in new approach methodologies
· Anna J. van der Zalm · 2022 · 252 citations · Cited by this paper
Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization
· Katie Paul Friedman · 2019 · 250 citations · Cited by this paper
The ECVAM International Validation Study on in Vitro Tests for Acute Skin Irritation: Report on the Validity of the EPISKIN and EpiDerm Assays and on the Skin Integrity Function Test
· Horst Spielmann · 2007 · 230 citations · Cited by this paper
Guideline No. 497: Defined Approaches on Skin Sensitisation
· OECD · 2021 · 228 citations · Cited by this paper
Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption
· OECD · 2018 · 224 citations · Cited by this paper
The ECVAM International Validation Study on In Vitro Tests for Skin Corrosivity. 2. Results and Evaluation by the Management Team
· Julia H. Fentem · 1998 · 213 citations · Cited by this paper
Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity
· Anna Bal‐Price · 2018 · 211 citations · Cited by this paper
Non-animal methods to predict skin sensitization (II): an assessment of defined approaches
· Nicole Kleinstreuer · 2018 · 206 citations · Cited by this paper
Accelerating the Pace of Chemical Risk Assessment
· Robert J. Kavlock · 2018 · 195 citations · Cited by this paper
Use of fish embryo toxicity tests for the prediction of acute fish toxicity to chemicals
· Scott E. Belanger · 2013 · 189 citations · Cited by this paper
Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database
· Sebastian Hoffmann · 2018 · 188 citations · Cited by this paper
Comparison of In Vitro and In Vivo Screening Models for Androgenic and Estrogenic Activities
· Edwin Sonneveld · 2005 · 184 citations · Cited by this paper
Macroevolution is more than repeated rounds of microevolution
· Douglas H. Erwin · 2000 · 179 citations · Cited by this paper
Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy
· Joanna S. Jaworska · 2015 · 167 citations · Cited by this paper
Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making
· Alicia Paini · 2018 · 157 citations · Cited by this paper
Quantifying Processes Determining the Free Concentration of Phenanthrene in Basal Cytotoxicity Assays
· Nynke I. Kramer · 2012 · 150 citations · Cited by this paper
The dawning of a new age of toxicology
· Marcel Leist · 2008 · 148 citations · Cited by this paper
The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories
· Andreas Natsch · 2010 · 131 citations · Cited by this paper
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