Research map: Harnessing Repurposed Drugs to Enhance Temozolomide Efficacy in Glioblastoma

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  1. Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma · Roger Stupp · 2005 · 22129 citations · Cited by this paper
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  13. Adding Chloroquine to Conventional Treatment for Glioblastoma Multiforme · Julio Sotelo · 2006 · 517 citations · Cited by this paper
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  15. Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases · Md. Abdul Alim Al‐Bari · 2015 · 474 citations · Cited by this paper
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  17. Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma · Michael Weller · 2011 · 294 citations · Cited by this paper
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  19. Overcoming the legal and regulatory barriers to drug repurposing · Alasdair M. Breckenridge · 2018 · 228 citations · Cited by this paper
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  21. Brain tumor stem cells: Molecular characteristics and their impact on therapy · David L. Schonberg · 2013 · 206 citations · Cited by this paper
  22. Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma · Xueqing Q. Lun · 2016 · 201 citations · Cited by this paper
  23. Potential therapeutic implications of cancer stem cells in glioblastoma · Lin Cheng · 2010 · 193 citations · Cited by this paper
  24. Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide · George C. Bobustuc · 2010 · 159 citations · Cited by this paper
  25. Anti-invasive efficacy and survival benefit of the YAP-TEAD inhibitor verteporfin in preclinical glioblastoma models · Anne Marie Barrette · 2021 · 147 citations · Cited by this paper
  26. Disulfiram, a drug widely used to control alcoholism, suppresses self-renewal of glioblastoma and overrides resistance to temozolomide · Joanna Triscott · 2012 · 140 citations · Cited by this paper
  27. NF-κB activation by double-strand breaks · Yvette Habraken · 2006 · 138 citations · Cited by this paper
  28. Characterization of sonic hedgehog as a novel NF‐κB target gene that promotes NF‐κB‐mediated apoptosis resistance and tumor growth in vivo · Hubert Kasperczyk · 2008 · 136 citations · Cited by this paper
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  30. Many faces of NF-κB signaling induced by genotoxic stress · Zhao‐Hui Wu · 2007 · 131 citations · Cited by this paper
  31. Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial · Inge Compter · 2020 · 119 citations · Cited by this paper
  32. The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells · Seung Woo Lee · 2015 · 117 citations · Cited by this paper
  33. The NFκB pathway: a therapeutic target in glioblastoma · Lorena Nogueira · 2011 · 110 citations · Cited by this paper
  34. Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood?brain barrier of Abcb1a gene knockout mice · Jun-Sheng Wang · 2004 · 108 citations · Cited by this paper
  35. Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo · Zhiyun Yu · 2015 · 103 citations · Cited by this paper
  36. Mechanisms of the Deleterious Effects of Tamoxifen on Mitochondrial Respiration Rate and Phosphorylation Efficiency · Carla M. P. Cardoso · 2001 · 102 citations · Cited by this paper
  37. Bortezomib inhibits growth and sensitizes glioma to temozolomide (TMZ) via down-regulating the FOXM1–Survivin axis · Jun‐Hai Tang · 2019 · 99 citations · Cited by this paper
  38. Withholding temozolomide in glioblastoma patients with unmethylated MGMT promoter—still a dilemma?: Table 1. · Monika E. Hegi · 2015 · 98 citations · Cited by this paper
  39. Mechanism of metformin regulation in central nervous system: Progression and future perspectives · Gui Cao · 2022 · 98 citations · Cited by this paper

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