Research map: YAP/TEAD complex restricts H3K27ac deposition to suppress testosterone synthesis in adult Leydig cells

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  1. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control · Bin Zhao · 2007 · 3210 citations · Cited by this paper
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  7. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF β-TRCP · Bin Zhao · 2010 · 1469 citations · Cited by this paper
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  9. Leydig cells: formation, function, and regulation† · Barry R. Zirkin · 2018 · 744 citations · Cited by this paper
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  11. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway · Zhipeng Meng · 2015 · 556 citations · Cited by this paper
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  15. Gonadotropin binding and stimulation of cyclic adenosine 3':5'-monophosphate and testosterone production in isolated Leydig cells. · Carole R. Mendelson · 1975 · 417 citations · Cited by this paper
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  17. Identical origin of adrenal cortex and gonad revealed by expression profiles of Ad4BP/SF‐1 · Osamu Hatano · 1996 · 304 citations · Cited by this paper
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  19. Contribution of Leydig and Sertoli Cells to Testosterone Production in Mouse Fetal Testes · Yuichi Shima · 2012 · 295 citations · Cited by this paper
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  21. Origin, differentiation and regulation of fetal and adult Leydig cells · René Habert · 2001 · 295 citations · Cited by this paper
  22. Leydig cells: From stem cells to aging · Haolin Chen · 2009 · 278 citations · Cited by this paper
  23. Hippo Signaling in Embryogenesis and Development · ZhengMing Wu · 2020 · 257 citations · Cited by this paper
  24. The Hippo signaling pathway in development and regeneration · Zhenxing Zhong · 2024 · 202 citations · Cited by this paper
  25. Basics of androgen synthesis and action · Rawda Naamneh Elzenaty · 2022 · 195 citations · Cited by this paper
  26. Hormone Regulation in Testicular Development and Function · Lu Li · 2024 · 154 citations · Cited by this paper
  27. YAP induces an oncogenic transcriptional program through TET1-mediated epigenetic remodeling in liver growth and tumorigenesis · Bo-Kuan Wu · 2022 · 93 citations · Cited by this paper
  28. Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia · Massimo Alfano · 2021 · 89 citations · Cited by this paper
  29. Actin like-6A promotes glioma progression through stabilization of transcriptional regulators YAP/TAZ · Jianxiong Ji · 2018 · 82 citations · Cited by this paper
  30. Androgens and spermatogenesis · Sophie Christin‐Maître · 2022 · 72 citations · Cited by this paper
  31. Regulation of the Proliferation and Differentiation of Leydig Stem Cells in the Adult Testis1 · Hana M. Odeh · 2014 · 68 citations · Cited by this paper
  32. Deciphering the origins and fates of steroidogenic lineages in the mouse testis · Herta Ademi · 2022 · 62 citations · Cited by this paper
  33. In Vivo Genetic Manipulation of Spermatogonial Stem Cells and Their Microenvironment by Adeno-Associated Viruses · Satoshi Watanabe · 2018 · 58 citations · Cited by this paper
  34. Icariin protects mouse Leydig cell testosterone synthesis from the adverse effects of di(2-ethylhexyl) phthalate · Jiandong Sun · 2019 · 58 citations · Cited by this paper
  35. SF-1 deficiency causes lipid accumulation in Leydig cells via suppression of STAR and CYP11A1 · Megumi Hatano · 2016 · 53 citations · Cited by this paper
  36. Two Hippo signaling modules orchestrate liver size and tumorigenesis · Sixian Qi · 2023 · 51 citations · Cited by this paper
  37. The regulation and function of the Hippo pathway in heart regeneration · Shijie Liu · 2018 · 35 citations · Cited by this paper
  38. CircGPRC5A enhances colorectal cancer progress by stabilizing PPP1CA and inducing YAP dephosphorylation · Zhenzhou Chen · 2023 · 32 citations · Cited by this paper
  39. Mechanism of Testosterone Deficiency in the Transgenic Sickle Cell Mouse · Biljana Musicki · 2015 · 22 citations · Cited by this paper

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