Research map: Bridging the validation gap: organoids as functional decision systems in drug repurposing

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  1. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche · Toshiro Sato · 2009 · 7384 citations · Cited by this paper
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  25. A functional CFTR assay using primary cystic fibrosis intestinal organoids · Johanna F. Dekkers · 2013 · 1019 citations · Cited by this paper
  26. Network-based prediction of drug combinations · Feixiong Cheng · 2019 · 898 citations · Cited by this paper
  27. Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients · Salo Ooft · 2019 · 867 citations · Cited by this paper
  28. Disease Modeling in Stem Cell-Derived 3D Organoid Systems · Devanjali Dutta · 2017 · 852 citations · Cited by this paper
  29. In vitro generation of human pluripotent stem cell derived lung organoids · Briana R. Dye · 2015 · 845 citations · Cited by this paper
  30. Limitations of Animal Studies for Predicting Toxicity in Clinical Trials · Gail A. Van Norman · 2019 · 703 citations · Cited by this paper
  31. Activity of Selumetinib in Neurofibromatosis Type 1–Related Plexiform Neurofibromas · Eva Dombi · 2016 · 692 citations · Cited by this paper
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  35. A review of computational drug repositioning: strategies, approaches, opportunities, challenges, and directions · Tamer N. Jarada · 2020 · 405 citations · Cited by this paper
  36. Phenotypic landscape of intestinal organoid regeneration · Ilya Lukonin · 2020 · 296 citations · Cited by this paper
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  38. ATM and the Molecular Pathogenesis of Ataxia Telangiectasia · Peter J. McKinnon · 2011 · 240 citations · Cited by this paper
  39. Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology · Ranjie Xu · 2021 · 224 citations · Cited by this paper

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