Research map: Dual hypocretin receptor antagonism reduces oxycodone seeking and attenuates aberrant dopamine transporter function during abstinence

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  1. Direct Involvement of Orexinergic Systems in the Activation of the Mesolimbic Dopamine Pathway and Related Behaviors Induced by Morphine · Minoru Narita · 2006 · 521 citations · Cited by this paper
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  19. The Motivation to Self-Administer is Increased After a History of Spiking Brain Levels of Cocaine · Benjamin Zimmer · 2012 · 180 citations · Cited by this paper
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  21. Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration · Rodrigo A. España · 2010 · 178 citations · Cited by this paper
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  23. Discovery and development of orexin receptor antagonists as therapeutics for insomnia · Christopher J. Winrow · 2013 · 155 citations · Cited by this paper
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  25. Orexin / hypocretin 1 receptor antagonist reduces heroin self‐administration and cue‐induced heroin seeking · Rachel J. Smith · 2012 · 129 citations · Cited by this paper
  26. PET imaging of dopamine transporter and drug craving during methadone maintenance treatment and after prolonged abstinence in heroin users · Jie Shi · 2007 · 106 citations · Cited by this paper
  27. Hypocretin/Orexin Regulation of Dopamine Signaling and Cocaine Self-Administration Is Mediated Predominantly by Hypocretin Receptor 1 · Courtney D. Prince · 2014 · 88 citations · Cited by this paper
  28. Intermittent self‐administration of fentanyl induces a multifaceted addiction state associated with persistent changes in the orexin system · Jennifer E. C. Fragale · 2020 · 86 citations · Cited by this paper
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  31. Suvorexant, an orexin/hypocretin receptor antagonist, attenuates motivational and hedonic properties of cocaine · Taylor A. Gentile · 2017 · 80 citations · Cited by this paper
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  34. Molecular Adaptations in the Rat Dorsal Striatum and Hippocampus Following Abstinence-Induced Incubation of Drug Seeking After Escalated Oxycodone Self-Administration · Christopher A. Blackwood · 2018 · 62 citations · Cited by this paper
  35. Availability of dopamine and serotonin transporters in opioid-dependent users—a two-isotope SPECT study · Tzung Lieh Yeh · 2011 · 57 citations · Cited by this paper
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  38. Persistent effects of the orexin-1 receptor antagonist SB-334867 on motivation for the fast acting opioid remifentanil · Aida Mohammadkhani · 2019 · 51 citations · Cited by this paper
  39. Acute ovarian hormone treatment in freely cycling female rats regulates distinct aspects of heroin seeking · Maribel Vázquez · 2019 · 47 citations · Cited by this paper

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