Research map: JNK and p53 cause human and mouse β cell death during excessive unfolded protein response

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  1. STAR: ultrafast universal RNA-seq aligner · Alexander Yu. Dobin · 2012 · 58150 citations · Cited by this paper
  2. Diabetic and ER-stressed pancreatic islet β cells are in need of some JNK removal · Jonathan M. Palozzi · 2026 · Cites this paper
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  20. Cell-Permeable Peptide Inhibitors of JNK · Christophe Bonny · 2001 · 573 citations · Cited by this paper
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  22. Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting · Min Ni · 2011 · 542 citations · Cited by this paper
  23. MEKK1/JNK signaling stabilizes and activates p53 · Serge Yu. Fuchs · 1998 · 527 citations · Cited by this paper
  24. Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress · Rajarshi Ghosh · 2014 · 501 citations · Cited by this paper
  25. c-Jun N-terminal Kinase (JNK) Mediates Feedback Inhibition of the Insulin Signaling Cascade · Yong Hee Lee · 2003 · 437 citations · Cited by this paper
  26. GRP78/BiP Is Required for Cell Proliferation and Protecting the Inner Cell Mass from Apoptosis during Early Mouse Embryonic Development · Shengzhan Luo · 2006 · 435 citations · Cited by this paper
  27. Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis · Donalyn Scheuner · 2005 · 419 citations · Cited by this paper
  28. Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts. · Robert P. C. Shiu · 1977 · 379 citations · Cited by this paper
  29. Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model · Sarah A. Tersey · 2012 · 365 citations · Cited by this paper
  30. Discovery of Potent and Selective Covalent Inhibitors of JNK · Tinghu Zhang · 2012 · 364 citations · Cited by this paper
  31. Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide · Hideaki Kaneto · 2004 · 337 citations · Cited by this paper
  32. Islet β cell mass in diabetes and how it relates to function, birth, and death · Gordon C. Weir · 2013 · 296 citations · Cited by this paper
  33. The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes · Bengt‐Frederik Belgardt · 2015 · 283 citations · Cited by this paper
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  35. Ins1 Cre knock-in mice for beta cell-specific gene recombination · Bernard Thorens · 2014 · 257 citations · Cited by this paper
  36. Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus · Jing Yong · 2021 · 236 citations · Cited by this paper
  37. Insulin demand regulates β cell number via the unfolded protein response · Rohit B. Sharma · 2015 · 224 citations · Cited by this paper
  38. Pancreatic β-Cell Failure and Diabetes in Mice With a Deletion Mutation of the Endoplasmic Reticulum Molecular Chaperone Gene P58IPK · Warren Ladiges · 2005 · 213 citations · Cited by this paper
  39. BiP and Its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions · Julia Behnke · 2015 · 207 citations · Cited by this paper

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