Research map: N6 ‐Methyladenosine Demethylase FTO Mitigates Cerebral Ischemia–Reperfusion Injury by Suppressing AQP4 Expression

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  1. Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons · Kate D. Meyer · 2012 · 4442 citations · Cited by this paper
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  13. FTO-Dependent N 6 -Methyladenosine Regulates Cardiac Function During Remodeling and Repair · Prabhu Mathiyalagan · 2018 · 616 citations · Cited by this paper
  14. Chronic Smoking Impairs Glymphatic Transport and Cognitive Function in Adolescent Mice Through Cardiac, Vascular, and Perivascular Aquaporin‐4 Mechanisms · 2026 · Related
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  22. Glial Cells Protect Neurons Against Oxidative Stress via Transcriptional Up‐Regulation of the Glutathione Synthesis · Emi Iwata‐Ichikawa · 1999 · 173 citations · Cited by this paper
  23. Acute Ischemic Stroke Intervention · Priyank Khandelwal · 2016 · 167 citations · Cited by this paper
  24. Circular RNA expression alterations are involved in OGD/R-induced neuron injury · Shao-Peng Lin · 2016 · 161 citations · Cited by this paper
  25. N6-methyladenosine and Neurological Diseases · Nan Zhang · 2022 · 160 citations · Cited by this paper
  26. N6‐methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO ‐ PGC ‐1α signalling axis · Changshui Zhuang · 2019 · 154 citations · Cited by this paper
  27. Transient Focal Ischemia Significantly Alters the m 6 A Epitranscriptomic Tagging of RNAs in the Brain · Anil Kiran Chokkalla · 2019 · 152 citations · Cited by this paper
  28. FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling · Huajie Li · 2018 · 148 citations · Cited by this paper
  29. Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial · Wouter van der Steen · 2022 · 145 citations · Cited by this paper
  30. N 6 -methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury · Kaiwei Xu · 2020 · 136 citations · Cited by this paper
  31. The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage · Qian Zhang · 2019 · 131 citations · Cited by this paper
  32. Deletion of the Inducible 70-kDa Heat Shock Protein Genes in Mice Impairs Cardiac Contractile Function and Calcium Handling Associated With Hypertrophy · Yun Kyung Kim · 2006 · 127 citations · Cited by this paper
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  35. Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-κB signaling in an IL-6-dependent manner · Lin Sun · 2017 · 95 citations · Cited by this paper
  36. HSP70 and HSP90 in neurodegenerative diseases · Abha A. Gupta · 2019 · 93 citations · Cited by this paper
  37. The roles of aquaporin‐4 in brain edema following neonatal hypoxia ischemia and reoxygenation in a cultured rat astrocyte model · Xuemei Fu · 2007 · 69 citations · Cited by this paper
  38. Alteration of N6 -Methyladenosine mRNA Methylation in a Rat Model of Cerebral Ischemia–Reperfusion Injury · Dazhuang Yi · 2021 · 69 citations · Cited by this paper
  39. FTO inhibits oxidative stress by mediating m6A demethylation of Nrf2 to alleviate cerebral ischemia/reperfusion injury · Lijing Hou · 2022 · 65 citations · Cited by this paper

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