Research map: The utility of FRET/FLIM-based bioassays for monitoring Nrf2 activation in single live cells

Back to the article

Papers in this map

  1. Engineering and characterization of a superfolder green fluorescent protein · J.D. Pédelacq · 2005 · 2505 citations · Cited by this paper
  2. Nicotine drives lung cancer progression by suppressing cuproptosis through the LIAS–DLAT axis and promoting M2 macrophage polarization · 2026 · Related
  3. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants · Albena T. Dinkova‐Kostova · 2002 · 1954 citations · Cited by this paper
  4. Cyclophilin D (CypD) promotes mitochondrial impairment, synaptic defects, cognitive loss, and tau pathology during aging · 2026 · Related
  5. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 · Evanna L. Mills · 2018 · 1944 citations · Cited by this paper
  6. Myeloid HIF-1α couples glycolytic energy supply with NCF2-dependent oxidative killing to protect against Klebsiella pneumoniae pneumonia · 2026 · Related
  7. Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases · Antonio Cuadrado · 2019 · 1480 citations · Cited by this paper
  8. Inhibiting VDAC1 oligomerization attenuated cerebral ischemia-reperfusion injury by promoting mitophagy via reduced LONP1 interaction · 2026 · Related
  9. Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress · Donna D. Zhang · 2003 · 1476 citations · Cited by this paper
  10. Crosstalk Between Mitophagy and Metabolism in Cancer: Mechanisms and Therapeutic Opportunities · 2026 · Related
  11. Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy · Yoshinobu Ichimura · 2013 · 1256 citations · Cited by this paper
  12. Salvianolic acid B mitigates neuronal ferroptosis after intracerebral hemorrhage in rats through a Piezo1-associated AMPK–mTOR pathway · 2026 · Related
  13. Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription · H.-C. Huang · 2002 · 1040 citations · Cited by this paper
  14. Sucralose promotes cardiac redox-metabolic remodeling through MRPL12-associated mitoribosomal stress · 2026 · Related
  15. Advanced Time-Correlated Single Photon Counting Techniques · Wolfgang H. Becker · 2005 · 1027 citations · Cited by this paper
  16. GPX3 downregulation in alveolar macrophages amplifies IL-17–dependent redox–inflammation crosstalk in ARDS · 2026 · Related
  17. Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model · Kit I. Tong · 2006 · 756 citations · Cited by this paper
  18. VBIT-4 attenuates diabetes-associated cardiovascular mitochondrial dysfunction and ROS production in a mouse model of diabetes and hyperlipidemic cellular assays · 2026 · Related
  19. Dimerization of Substrate Adaptors Can Facilitate Cullin-mediated Ubiquitylation of Proteins by a “Tethering” Mechanism · Michael J. McMahon · 2006 · 489 citations · Cited by this paper
  20. Loss of microglial ATM drives synaptic pruning and cognitive impairment in epilepsy · 2026 · Related
  21. Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals · Michael J. McMahon · 2010 · 448 citations · Cited by this paper
  22. Redox-regulated Turnover of Nrf2 Is Determined by at Least Two Separate Protein Domains, the Redox-sensitive Neh2 Degron and the Redox-insensitive Neh6 Degron · Michael J. McMahon · 2004 · 402 citations · Cited by this paper
  23. Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex · Liam Baird · 2013 · 388 citations · Cited by this paper
  24. Broccoli or Sulforaphane: Is It the Source or Dose That Matters? · Yoko Yagishita · 2019 · 348 citations · Cited by this paper
  25. Tandem fluorescent protein timers for in vivo analysis of protein dynamics · Anton Khmelinskii · 2012 · 310 citations · Cited by this paper
  26. Modification of Keap1 Cysteine Residues by Sulforaphane · Chenqi Hu · 2011 · 305 citations · Cited by this paper
  27. Mechanism of Action of Sulforaphane: Inhibition of p38 Mitogen-Activated Protein Kinase Isoforms Contributing to the Induction of Antioxidant Response Element–Mediated Heme Oxygenase-1 in Human Hepatoma HepG2 Cells · Young‐Sam Keum · 2006 · 303 citations · Cited by this paper
  28. Advances and challenges in therapeutic targeting of NRF2 · Albena T. Dinkova‐Kostova · 2023 · 269 citations · Cited by this paper
  29. Thirty years of NRF2: advances and therapeutic challenges · Donna D. Zhang · 2025 · 244 citations · Cited by this paper
  30. Fanciful FRET · Steven S. Vogel · 2006 · 242 citations · Cited by this paper
  31. Rapid and Sustainable Detoxication of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China · Patricia A. Egner · 2014 · 192 citations · Cited by this paper
  32. Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism · Yuta Horie · 2021 · 188 citations · Cited by this paper
  33. Redox control of protein degradation · Marta Pajares · 2015 · 180 citations · Cited by this paper
  34. FRET microscopy in the living cell: Different approaches, strengths and weaknesses · Sergi Padilla‐Parra · 2012 · 180 citations · Cited by this paper
  35. Electrophilic tuning of the chemoprotective natural product sulforaphane · Young‐Hoon Ahn · 2010 · 169 citations · Cited by this paper
  36. KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients · Luisa Quinti · 2017 · 141 citations · Cited by this paper
  37. Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1–Nrf2 Protein–Protein Interaction · Hélène Charlotte Bertrand · 2015 · 123 citations · Cited by this paper
  38. Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans · Elena V. Knatko · 2015 · 122 citations · Cited by this paper
  39. p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex · Shasha Tao · 2017 · 112 citations · Cited by this paper

Source: OpenAlex (CC0)