Research map: Design and monitoring of randomized trials in vision research with binary endpoints

Back to the article

Papers in this map

  1. A Multiple Testing Procedure for Clinical Trials · Peter C. O’Brien · 1979 · 3371 citations · Cited by this paper
  2. Covariate adjustment in randomized trials: An overview · 2026 · Related
  3. A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss · Age-Related Eye Disease Study Research Group · 2001 · 3295 citations · Cited by this paper
  4. Covariate adjustment in randomized clinical trials: From general theory to practical insights · 2026 · Related
  5. Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial · Stephen R. Russell · 2017 · 1968 citations · Cited by this paper
  6. Additional crossovers in cluster randomised crossover trials do not always increase statistical power · 2026 · Related
  7. Group sequential methods in the design and analysis of clinical trials · Stuart Pocock · 1977 · 1795 citations · Cited by this paper
  8. Patient notification about pragmatic clinical trials conducted with a waiver of consent: A qualitative study · 2025 · Related
  9. Discrete Sequential Boundaries for Clinical Trials · K. K. Gordon Lan · 1983 · 1718 citations · Cited by this paper
  10. A review of use of external data and update on reporting standards in Sequential Multiple-Assignment Randomised Trials · 2025 · Related
  11. Early Treatment Diabetic Retinopathy Study Design and Baseline Patient Characteristics · * · 1991 · 693 citations · Cited by this paper
  12. Shaping the future of clinical trials through strategic foresight · 2026 · Related
  13. The Wilcoxon Signed Rank Test for Paired Comparisons of Clustered Data · BERNARD A. ROSNER · 2005 · 561 citations · Cited by this paper
  14. Bayesian design and analysis of two-arm cluster randomised trials using assurance: Extension to binary outcomes and comparison of Markov chain Monte Carlo and Integrated Nested Laplace Approximations · 2026 · Related
  15. The Age-related Eye Disease Study 2 (AREDS2) · Emily Y. Chew · 2012 · 420 citations · Cited by this paper
  16. Surrogate markers used as efficacy endpoints in NIH-sponsored clinical trials · 2026 · Related
  17. Design and analysis of clinical trials with clustering effects due to treatment · Chris Roberts · 2005 · 306 citations · Cited by this paper
  18. Evidence supporting European Medicines Agency drug approvals (2020–2023): A cross-sectional study of trial design and outcomes · 2026 · Related
  19. Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma · Jessica Cecile Hassel · 2023 · 289 citations · Cited by this paper
  20. Confirmatory evidence supporting single pivotal trial new drug approvals by the Food and Drug Administration, 2015 through 2023 · 2025 · Related
  21. Covariate adjustment in randomized controlled trials with dichotomous outcomes increases statistical power and reduces sample size requirements · Adrián Vladimir Hernández · 2004 · 262 citations · Cited by this paper
  22. A tutorial on sample size calculation for multiple-period cluster randomized parallel, cross-over and stepped-wedge trials using the Shiny CRT Calculator · Karla Hemming · 2019 · 261 citations · Cited by this paper
  23. The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma: IV. Ten-year mortality findings and prognostic factors. COMS report number 24 · Collaborative Ocular Melanoma Study Group · 2004 · 259 citations · Cited by this paper
  24. The advanced glaucoma intervention study (AGIS): 1. Study design and methods and baseline characteristics of study patients · The AGIS Investigators · 1994 · 247 citations · Cited by this paper
  25. Review of Recent Methodological Developments in Group-Randomized Trials: Part 2—Analysis · Elizabeth Louise Turner · 2017 · 209 citations · Cited by this paper
  26. Review of Recent Methodological Developments in Group-Randomized Trials: Part 1—Design · Elizabeth Louise Turner · 2017 · 171 citations · Cited by this paper
  27. A generalized Dunnett test for multi-arm multi-stage clinical studies with treatment selection · Dominic Magirr · 2012 · 169 citations · Cited by this paper
  28. Tutorial on Biostatistics: Linear Regression Analysis of Continuous Correlated Eye Data · Gui‐Shuang Ying · 2017 · 153 citations · Cited by this paper
  29. Optimal design of multi‐arm multi‐stage trials · James M. S. Wason · 2012 · 129 citations · Cited by this paper
  30. Tutorial on Biostatistics: Statistical Analysis for Correlated Binary Eye Data · Gui‐Shuang Ying · 2017 · 116 citations · Cited by this paper
  31. Multicenter trial of early treatment for retinopathy of prematurity: study design · Early Treatment for Retinopathy of Prematurity Cooperative Group · 2004 · 97 citations · Cited by this paper
  32. Extension of the Rank Sum Test for Clustered Data: Two‐Group Comparisons with Group Membership Defined at the Subunit Level · BERNARD A. ROSNER · 2006 · 89 citations · Cited by this paper
  33. Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research · Chul Woo Ahn · 2014 · 86 citations · Cited by this paper
  34. Randomized trial of the ForeseeHome monitoring device for early detection of neovascular age-related macular degeneration. The HOme Monitoring of the Eye (HOME) study design — HOME Study report number 1 · Emily Y. Chew · 2014 · 71 citations · Cited by this paper
  35. Management of Ocular Allergy Itch With an Antihistamine-Releasing Contact Lens · Brian Pall · 2019 · 58 citations · Cited by this paper
  36. Response to AREDS supplements according to genetic factors: survival analysis approach using the eye as the unit of analysis · Johanna M. Seddon · 2016 · 56 citations · Cited by this paper
  37. Flexible sequential designs for multi‐arm clinical trials · Dominic Magirr · 2014 · 52 citations · Cited by this paper
  38. Cluster randomised crossover trials with binary data and unbalanced cluster sizes: Application to studies of near-universal interventions in intensive care · Andrew Benjamin Forbes · 2014 · 52 citations · Cited by this paper
  39. A comparison of goodness of fit tests for the logistic GEE model · Scott R. Evans · 2004 · 52 citations · Cited by this paper

Source: OpenAlex (CC0)