Research map: Chinese Medicine for Renal Fibrosis Prevention and Treatment in Chronic Kidney Disease: Pharmacological Mechanisms and Therapeutic Potential

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  1. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease · Paul E. Stevens · 2024 · 8239 citations · Cited by this paper
  2. System Pharmacology-Based Anti-proliferation and Anti-angiogenesis Mechanisms of Oridonin in Psoriasis Keratinocytes by Blocking PI3K/AKT Signaling Pathway · 2026 · Related
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  4. Berberine Regulates Hepatic Fatty Acid Metabolism via AMPK/SIRT1/PGC-1α Pathway · 2026 · Related
  5. Chronic Kidney Disease Diagnosis and Management · Teresa K. Chen · 2019 · 1819 citations · Cited by this paper
  6. Tanshinone IIA reduces tubulointerstitial fibrosis by suppressing GSDMD-mediated pyroptosis · 2025 · Related
  7. Chronic kidney disease · Kamyar Kalantar‐Zadeh · 2021 · 1474 citations · Cited by this paper
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  9. Macrophages: versatile players in renal inflammation and fibrosis · Patrick Ming‐Kuen Tang · 2019 · 1056 citations · Cited by this paper
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  11. Kidney fibrosis: from mechanisms to therapeutic medicines · Rongshuang Huang · 2023 · 779 citations · Cited by this paper
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  13. Epigenetics and epigenomics in diabetic kidney disease and metabolic memory · Mitsuo V. Kato · 2019 · 615 citations · Cited by this paper
  14. Effect of Taoren Honghua Jian Granule on NLRP3 Inflammasome Expression in Patients with Stable Coronary Artery Disease: A Multi-Center, Double-blind, Randomized Controlled Trial · 2026 · Related
  15. The fibrogenic niche in kidney fibrosis: components and mechanisms · Li Li · 2022 · 453 citations · Cited by this paper
  16. Astragaloside IV Mitigates Subarachnoid Hemorrhage-Induced Brain Injury via Regulating Microglial Polarization and Neuroinflammation Mediated by cGAS/STING Pathway · 2026 · Related
  17. Renal fibrosis: Primacy of the proximal tubule · Leslie S. Gewin · 2018 · 230 citations · Cited by this paper
  18. Integrated Network Pharmacology and Proteomics Reveal Anti-tumor Mechanism of Securinine in Ovarian Cancer · 2026 · Related
  19. Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways · Rui Li · 2019 · 211 citations · Cited by this paper
  20. Qingxin Jieyu Granule Ameliorates Myocardial Ischemia/Reperfusion Injury by Inhibiting Cardiomyocyte Pyroptosis via Regulating Circulating Exosomes · 2026 · Related
  21. Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer · M. Walraven · 2018 · 194 citations · Cited by this paper
  22. Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis · Fernanda do Valle Durães · 2020 · 156 citations · Cited by this paper
  23. Gut microbiota regulates oxidative stress and inflammation: a double-edged sword in renal fibrosis · Xiaojun Li · 2024 · 144 citations · Cited by this paper
  24. The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice · Wei Zhou · 2022 · 140 citations · Cited by this paper
  25. Lactobacillus species ameliorate membranous nephropathy through inhibiting the aryl hydrocarbon receptor pathway via tryptophan‐produced indole metabolites · Hua Miao · 2023 · 140 citations · Cited by this paper
  26. Inflammation in kidney repair: Mechanism and therapeutic potential · Ying Fu · 2022 · 139 citations · Cited by this paper
  27. Targeting Lactobacillus johnsonii to reverse chronic kidney disease · Hua Miao · 2024 · 134 citations · Cited by this paper
  28. Snai1-induced partial epithelial–mesenchymal transition orchestrates p53–p21-mediated G2/M arrest in the progression of renal fibrosis via NF-κB-mediated inflammation · Ruochen Qi · 2021 · 128 citations · Cited by this paper
  29. Huangkui capsule alleviates renal tubular epithelial–mesenchymal transition in diabetic nephropathy via inhibiting NLRP3 inflammasome activation and TLR4/NF-κB signaling · Wen-Bei Han · 2018 · 113 citations · Cited by this paper
  30. Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis · Sandra Rayego‐Mateos · 2021 · 107 citations · Cited by this paper
  31. Siglec-F–expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis · Seungwon Ryu · 2022 · 105 citations · Cited by this paper
  32. Renoprotective effect of calycosin in high fat diet-fed/STZ injected rats: Effect on IL-33/ST2 signaling, oxidative stress and fibrosis suppression · Nehal Mohsen Elsherbiny · 2019 · 86 citations · Cited by this paper
  33. Astragaloside IV/lncRNA-TUG1/TRAF5 signaling pathway participates in podocyte apoptosis of diabetic nephropathy rats · Xiao Lei · 2018 · 83 citations · Cited by this paper
  34. Berberine ameliorates chronic kidney disease through inhibiting the production of gut-derived uremic toxins in the gut microbiota · Li‐Bin Pan · 2022 · 81 citations · Cited by this paper
  35. Resveratrol suppresses the myofibroblastic phenotype and fibrosis formation in kidneys via proliferation‐related signalling pathways · Xing Zhang · 2019 · 78 citations · Cited by this paper
  36. Inhibition of PKM2 by shikonin impedes TGF-β1 expression by repressing histone lactylation to alleviate renal fibrosis · Tianya Xiang · 2024 · 75 citations · Cited by this paper
  37. Tangshen formula modulates gut Microbiota and reduces gut-derived toxins in diabetic nephropathy rats · Tingting Zhao · 2020 · 72 citations · Cited by this paper
  38. Salvianolic acid B attenuates epithelial-mesenchymal transition in renal fibrosis rats through activating Sirt1-mediated autophagy · Yu He · 2020 · 70 citations · Cited by this paper
  39. Tectorigenin protects against unilateral ureteral obstruction by inhibiting Smad3‐mediated ferroptosis and fibrosis · Jianchun Li · 2021 · 64 citations · Cited by this paper

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