Research map: Lactate/AARS1-mediated H3K18la in the modulation of ACSL4 transcription to trigger ferroptosis in myocardial ischemia reperfusion

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  1. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis · Zhi Zong · 2024 · 597 citations · Cited by this paper
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  13. Tumor Microenvironment: Lactic Acid Promotes Tumor Development · Yuting Gao · 2022 · 133 citations · Cited by this paper
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  15. Cardioprotection of pharmacological postconditioning on myocardial ischemia/reperfusion injury · Yushi Wu · 2020 · 84 citations · Cited by this paper
  16. Dissecting burden of alcoholic cardiomyopathy: age-period-cohort analysis from the global burden of disease study 2019 · 2026 · Related
  17. Tanshinone IIA confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis and apoptosis via VDAC1 · Tie Hu · 2023 · 81 citations · Cited by this paper
  18. Association of intracranial atherosclerotic stenosis with 1-year cognitive impairment after acute ischemic stroke or transient ischemic attack: a nationwide prospective cohort study · 2026 · Related
  19. Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect · Elizabeth K. Wiese · 2021 · 66 citations · Cited by this paper
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  21. Lactate regulates pathological cardiac hypertrophy via histone lactylation modification · Shuai‐Shuai Zhao · 2024 · 62 citations · Cited by this paper
  22. Klf6 aggravates myocardial ischemia/reperfusion injury by activating Acsl4 ‐mediated ferroptosis · Mali Qiu · 2023 · 29 citations · Cited by this paper
  23. Broadening horizons: The role of ferroptosis in myocardial ischemia–reperfusion injury · Ke Zhao · 2023 · 28 citations · Cited by this paper
  24. Expanded phenotype of AARS1-related white matter disease · Guy Helman · 2021 · 27 citations · Cited by this paper
  25. AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy · Jia Wei Hong · 2025 · 27 citations · Cited by this paper
  26. Enhancement of Mitochondrial Homeostasis: A Novel Approach to Attenuate Hypoxic Myocardial Injury · Zhijiang Guo · 2024 · 23 citations · Cited by this paper
  27. Hypertension-Driven Regulatory T-Cell Perturbations Accelerate Myocardial Ischemia-Reperfusion Injury · Xuan Sun · 2023 · 22 citations · Cited by this paper
  28. Propofol pretreatment inhibits ferroptosis and alleviates myocardial ischemia-reperfusion injury through the SLC16A13-AMPK-GPX4 pathway · Fan Sun · 2024 · 20 citations · Cited by this paper
  29. Lactate Metabolism and Lactylation Modification: New Opportunities and Challenges in Cardiovascular Disease · Mengyang Song · 2025 · 20 citations · Cited by this paper
  30. Oxamate Attenuates Glycolysis and ER Stress in Silicotic Mice · Na Mao · 2022 · 19 citations · Cited by this paper
  31. Hypoxia/reoxygenation-induced Glycolysis Mediates Myocardial Ischemia–reperfusion Injury Through Promoting the Lactylation of GPX4 · Yihua Wang · 2025 · 19 citations · Cited by this paper
  32. The Function of Circular RNAs in Myocardial Ischemia–Reperfusion Injury: Underlying Mechanisms and Therapeutic Advancement · Kaiyuan Chen · 2024 · 14 citations · Cited by this paper
  33. Hypoxia Aggravates Myocardial Ischemia/Reperfusion Injury Through the Promotion of Ferroptosis via ACSL4 Lactylation · Jiannan Lv · 2025 · 13 citations · Cited by this paper
  34. AARS1 and AARS2: From Protein Synthesis to Lactylation-Driven Oncogenesis · Lingyue Gao · 2025 · 12 citations · Cited by this paper
  35. AMPK, a key molecule regulating aging-related myocardial ischemia-reperfusion injury · Xiaorui Yin · 2024 · 10 citations · Cited by this paper
  36. Lactate/AARS1/H3K18la/LDHA positive feedback loop triggers ferroptosis, which participates in diabetic nephropathy via the modulation of ACSL4 transcription · Kang-Quan Hu · 2025 · 9 citations · Cited by this paper
  37. High Density Lipoprotein Reduces Blood Pressure and Protects Spontaneously Hypertensive Rats Against Myocardial Ischemia-Reperfusion Injury in an SR-BI Dependent Manner · Aishah Al‐Jarallah · 2022 · 8 citations · Cited by this paper
  38. Insight into myocardial ischemia-reperfusion injury from the perspective of ferroptosis · Xia Huang · 2024 · 8 citations · Cited by this paper
  39. Biomimetic Targeted Nanoplatform Exerts a Combined Effect of Alleviating Calcium Overload and Scavenging ROS to Attenuate the Inflammatory Response in Myocardial Ischemia-Reperfusion Injury · Lin Liu · 2025 · 6 citations · Cited by this paper

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