Research map: Epithelial-immune interface in asthma: Mechanistic insights driving novel therapeutic strategies

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Papers in this map

  1. Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease · Merin Elizabeth Kuruvilla · 2018 · 1252 citations · Cited by this paper
  2. Advances in manufacturing chimeric antigen receptor immune cell therapies · 2024 · Related
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  5. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand · Tomoki� Ito · 2005 · 1133 citations · Cited by this paper
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  7. Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma · Andrew N Menzies-Gow · 2021 · 1054 citations · Cited by this paper
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  9. A cellular census of human lungs identifies novel cell states in health and in asthma · Felipe A. Vieira Braga · 2019 · 990 citations · Cited by this paper
  10. The sweet and the bitter sides of galectin-1 in immunity: its role in immune cell functions, apoptosis, and immunotherapies for cancer with a focus on T cells · 2025 · Related
  11. Biologic Therapies for Severe Asthma · Guy G. Brusselle · 2022 · 725 citations · Cited by this paper
  12. Early-life risk factors which govern pro-allergic immunity · 2024 · Related
  13. Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease · Peter John Barnes · 2013 · 695 citations · Cited by this paper
  14. Micro-to multi-chimerism: the multiple facets of a singular phenomenon · 2025 · Related
  15. IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactions · Laurel A. Monticelli · 2015 · 541 citations · Cited by this paper
  16. Butyrate remodels the immune-epigenetic-gut-lung axis: Emerging mechanisms and therapeutic perspectives in asthma · 2026 · Related
  17. Pulmonary neuroendocrine cells amplify allergic asthma responses · Pengfei Sui · 2018 · 442 citations · Cited by this paper
  18. Pyoderma gangrenosum: pathogenetic mechanisms and their implications for treatment · 2025 · Related
  19. Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor · Dietmar M. W. Zaiss · 2013 · 423 citations · Cited by this paper
  20. Airway epithelial dysfunction in asthma pathogenesis: epigenetic mechanisms, inflammatory crosstalk, and therapeutic opportunities · 2026 · Related
  21. A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain · Dustin P. Green · 2019 · 414 citations · Cited by this paper
  22. Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma · Martin Depner · 2020 · 377 citations · Cited by this paper
  23. Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation · Hiroyuki Nagashima · 2019 · 327 citations · Cited by this paper
  24. Effect of tezepelumab on airway inflammatory cells, remodelling, and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma (CASCADE): a double-blind, randomised, placebo-controlled, phase 2 trial · Sarah E. Diver · 2021 · 327 citations · Cited by this paper
  25. Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial · Steven G. Kelsen · 2021 · 325 citations · Cited by this paper
  26. Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens · Caroline Perner · 2020 · 317 citations · Cited by this paper
  27. Role of thymic stromal lymphopoietin in allergy and beyond · Risa Ebina‐Shibuya · 2022 · 283 citations · Cited by this paper
  28. Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation · Rohit Dilip Divekar · 2014 · 258 citations · Cited by this paper
  29. Neutrophil Elastase and Chronic Lung Disease · Judith A. Voynow · 2021 · 237 citations · Cited by this paper
  30. Resolution of Allergic Inflammation and Airway Hyperreactivity Is Dependent upon Disruption of the T1/ST2–IL-33 Pathway · Jennifer Kearley · 2009 · 229 citations · Cited by this paper
  31. Th3 Cells in Peripheral Tolerance. I. Induction of Foxp3-Positive Regulatory T Cells by Th3 Cells Derived from TGF-β T Cell-Transgenic Mice · Yijun Carrier · 2007 · 228 citations · Cited by this paper
  32. Global, regional, and national burden of asthma and atopic dermatitis, 1990–2021, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021 · Jiyeon Oh · 2025 · 224 citations · Cited by this paper
  33. Global, regional, national burden of asthma from 1990 to 2021, with projections of incidence to 2050: a systematic analysis of the global burden of disease study 2021 · Linna Yuan · 2025 · 183 citations · Cited by this paper
  34. Potential role of senescent macrophages in radiation-induced pulmonary fibrosis · Lulu Su · 2021 · 174 citations · Cited by this paper
  35. TSLP and IL‐33 reciprocally promote each other's lung protein expression and ILC2 receptor expression to enhance innate type‐2 airway inflammation · Shinji Toki · 2020 · 173 citations · Cited by this paper
  36. Similarities and interplay between senescent cells and macrophages · Jacques V. Behmoaras · 2020 · 168 citations · Cited by this paper
  37. Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases · Sanjeethan C. Baksh · 2020 · 167 citations · Cited by this paper
  38. Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4/NF-kB signaling pathway · Zhiwei Wu · 2022 · 156 citations · Cited by this paper
  39. Airway remodelling in asthma and the epithelium: on the edge of a new era · Gilda Varricchi · 2024 · 146 citations · Cited by this paper

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