Research map: Navigating evidence-based recommendations for the management of systemic sclerosis

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  1. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension · Marc Humbert · 2022 · 2256 citations · Cited by this paper
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  3. Cyclophosphamide versus Placebo in Scleroderma Lung Disease · Donald P. Tashkin · 2006 · 1685 citations · Cited by this paper
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  6. Anti-CD19 CAR T cell therapy promotes skin remodelling in systemic sclerosis · 2026 · Related
  7. Update of EULAR recommendations for the treatment of systemic sclerosis · Otylia Kowal‐Bielecka · 2016 · 1128 citations · Cited by this paper
  8. Cellular therapies in systemic Sclerosis: immunopathogenesis-informed precision targeting with CAR-T and CAR-NK approaches · 2026 · Related
  9. Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial · Donald P. Tashkin · 2016 · 1083 citations · Cited by this paper
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  11. A multicenter, prospective, randomized, double‐blind, placebo‐controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma · Rachel K. Hoyles · 2006 · 742 citations · Cited by this paper
  12. 20 years of progress in the classification of immune-mediated diseases · 2026 · Related
  13. Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension · Marius M. Hoeper · 2023 · 728 citations · Cited by this paper
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  15. Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial · Dinesh Khanna · 2016 · 687 citations · Cited by this paper
  16. Decoding variants of uncertain significance in systemic autoinflammatory diseases · 2026 · Related
  17. Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial · Dinesh Khanna · 2020 · 674 citations · Cited by this paper
  18. Sex-dependent mechanisms in rheumatic diseases · 2026 · Related
  19. EULAR recommendations for the treatment of systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group (EUSTAR) · Otylia Kowal‐Bielecka · 2009 · 622 citations · Cited by this paper
  20. Rethinking early-stage knee osteoarthritis beyond radiography · 2026 · Related
  21. Systemic sclerosis · Elizabeth R. Volkmann · 2022 · 610 citations · Cited by this paper
  22. Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial · Marco Matucci‐Cerinic · 2010 · 503 citations · Cited by this paper
  23. Prediction of Pulmonary Complications and Long‐Term Survival in Systemic Sclerosis · Svetlana I. Nihtyanova · 2014 · 465 citations · Cited by this paper
  24. Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial · Toby M. Maher · 2022 · 292 citations · Cited by this paper
  25. Safety and efficacy of rituximab in systemic sclerosis (DESIRES): a double-blind, investigator-initiated, randomised, placebo-controlled trial · Satoshi Ebata · 2021 · 273 citations · Cited by this paper
  26. EULAR recommendations for the treatment of systemic sclerosis: 2023 update · Francesco Del Galdo · 2024 · 260 citations · Cited by this paper
  27. Treatment algorithm for pulmonary arterial hypertension · Kelly Chin · 2024 · 241 citations · Cited by this paper
  28. Using Autoantibodies and Cutaneous Subset to Develop Outcome‐Based Disease Classification in Systemic Sclerosis · Svetlana I. Nihtyanova · 2019 · 223 citations · Cited by this paper
  29. Efficacy and safety of nintedanib in patients with systemic sclerosis-associated interstitial lung disease treated with mycophenolate: a subgroup analysis of the SENSCIS trial · Kristin B. Highland · 2021 · 219 citations · Cited by this paper
  30. BSR and BHPR guideline for the treatment of systemic sclerosis · Christopher P. Denton · 2016 · 217 citations · Cited by this paper
  31. 2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Treatment of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases · Sindhu R. Johnson · 2024 · 192 citations · Cited by this paper
  32. Treatment of Systemic Sclerosis–associated Interstitial Lung Disease: Evidence-based Recommendations. An Official American Thoracic Society Clinical Practice Guideline · Ganesh Raghu · 2023 · 171 citations · Cited by this paper
  33. Efficacy of sildenafil on ischaemic digital ulcer healing in systemic sclerosis: the placebo-controlled SEDUCE study · Eric HACHULLA · 2015 · 165 citations · Cited by this paper
  34. Progression of patients with Raynaud's phenomenon to systemic sclerosis: a five-year analysis of the European Scleroderma Trial and Research group multicentre, longitudinal registry study for Very Early Diagnosis of Systemic Sclerosis (VEDOSS) · Silvia Bellando-Randone · 2021 · 160 citations · Cited by this paper
  35. EULAR recommendations for the non-pharmacological management of systemic lupus erythematosus and systemic sclerosis · Ioannis Parodis · 2023 · 135 citations · Cited by this paper
  36. Experience with azathioprine in systemic sclerosis associated with interstitial lung disease · Keertan Dheda · 2004 · 111 citations · Cited by this paper
  37. Elucidating the burden of recurrent and chronic digital ulcers in systemic sclerosis: long-term results from the DUO Registry · Marco Matucci‐Cerinic · 2015 · 106 citations · Cited by this paper
  38. Renal Disease and Systemic Sclerosis: an Update on Scleroderma Renal Crisis · Alice R Cole · 2022 · 95 citations · Cited by this paper
  39. The 2024 British Society for Rheumatology guideline for management of systemic sclerosis · Christopher P. Denton · 2024 · 92 citations · Cited by this paper

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