Research map: The dual role of the cGAS-STING signaling pathway in kidney diseases: from acute injury to chronic fibrosis – molecular mechanisms and precision therapeutic strategies

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Papers in this map

  1. Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury · Hiroshi Maekawa · 2019 · 592 citations · Cited by this paper
  2. Free Mitochondrial DNA and Mitophagy Dysfunction in Diabetic Kidney Disease: A Central Mitochondrial–Inflammatory Axis Driving Progressive Renal Injury · Aasthika Das · 2026 · Cites this paper
  3. Tislelizumab combined with Anti-GD2 antibody-based chemoimmunotherapy for pediatric relapsed/refractory high-risk neuroblastoma: a two-Case Report · 2026 · Related
  4. Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway · Chunyong Ding · 2020 · 312 citations · Cited by this paper
  5. Linalool in cancer pharmacology: pharmacokinetic limitations and preclinical cytotoxic evidence for translational development · 2026 · Related
  6. Role of the cGAS–STING pathway in systemic and organ-specific diseases · Sladjana Skopelja‐Gardner · 2022 · 310 citations · Cited by this paper
  7. A nomogram based on LASSO-logistic regression for predicting tocilizumab-associated hypofibrinogenemia in patients with rheumatic diseases · 2026 · Related
  8. A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis · Dan Zhang · 2022 · 291 citations · Cited by this paper
  9. Traditional Chinese medicine interventions targeting Wnt/β-catenin signaling in cerebral ischemia/reperfusion injury: a review · 2026 · Related
  10. Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD · Takanori Komada · 2018 · 156 citations · Cited by this paper
  11. NSFC-funded Chinese materia medica research (2015–2024): achievements output, research characteristics, and evolution · 2026 · Related
  12. Chronic kidney disease-induced muscle atrophy: Molecular mechanisms and promising therapies · Kexin Wang · 2022 · 126 citations · Cited by this paper
  13. Endothelial EPAS1 as a prognostic and therapeutic target in acute myocardial infarction: integrative bioinformatics, Mendelian randomization and experimental validation · 2026 · Related
  14. cGAS-STING activation contributes to podocyte injury in diabetic kidney disease · Nan Zang · 2022 · 111 citations · Cited by this paper
  15. Hematopoietic and T-lymphopoiesis-stimulating effects of a fluorinated pyrazolopiperidine β-cyclodextrin complex in cyclophosphamide-induced hematopoietic suppression · 2026 · Related
  16. Targeting the DNA damage response enhances CD70 CAR-T cell therapy for renal carcinoma by activating the cGAS-STING pathway · Feng Ji · 2021 · 100 citations · Cited by this paper
  17. Ganhai Weikang Capsules ameliorate functional dyspepsia in rats by modulating gut microbiota and host metabolic homeostasis · 2026 · Related
  18. IL-26 Confers Proinflammatory Properties to Extracellular DNA · Caroline Poli · 2017 · 84 citations · Cited by this paper
  19. Therapeutic potential of traditional Chinese medicine for hyperuricemia: mechanistic insights and clinical prospects · 2026 · Related
  20. NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease · Komuraiah Myakala · 2023 · 84 citations · Cited by this paper
  21. UNC93B1 attenuates the cGAS–STING signaling pathway by targeting STING for autophagy–lysosome degradation · Huifang Zhu · 2022 · 76 citations · Cited by this paper
  22. cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis · Anni Jiang · 2023 · 60 citations · Cited by this paper
  23. PCSK9 causes inflammation and cGAS / STING pathway activation in diabetic nephropathy · Zhicai Feng · 2023 · 53 citations · Cited by this paper
  24. METTL3-Mediated N6-Methyladenosine mRNA Modification and cGAS-STING Pathway Activity in Kidney Fibrosis · Yu-Cheng Tsai · 2024 · 51 citations · Cited by this paper
  25. Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney · Xiaoxin X. Wang · 2023 · 46 citations · Cited by this paper
  26. Genetic deficiency or pharmacological inhibition of cGAS–STING signalling suppresses kidney inflammation and fibrosis · Baihai Jiao · 2025 · 43 citations · Cited by this paper
  27. PTEN ‐induced kinase 1 is associated with renal aging, via the cGAS ‐ STING pathway · Min Heui Ha · 2023 · 40 citations · Cited by this paper
  28. The cGAS–STING signaling pathway: A central regulator and novel therapeutic target in skeletal muscle pathophysiology · Haiyan Jiang · 2026 · 37 citations · Cited by this paper
  29. Myricetin-Loaded Nanomicelles Protect against Cisplatin-Induced Acute Kidney Injury by Inhibiting the DNA Damage-cGAS–STING Signaling Pathway · Xueju Qi · 2022 · 33 citations · Cited by this paper
  30. Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction · Wei Shi · 2024 · 29 citations · Cited by this paper
  31. Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice · Dongyun Wang · 2024 · 28 citations · Cited by this paper
  32. Anlotinib suppresses proliferation, migration, and immune escape of gastric cancer cells by activating the cGAS-STING/IFN-β pathway · Min Yuan · 2022 · 27 citations · Cited by this paper
  33. Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway · Shuai Liu · 2023 · 27 citations · Cited by this paper
  34. Mechanisms and therapeutic potential of the cGAS–STING signaling pathway in macrophage activation and polarization · Hong Liu · 2026 · 27 citations · Cited by this paper
  35. Role of cGAS/STING pathway in aging and sexual dimorphism in diabetic kidney disease · Sherif Khedr · 2024 · 22 citations · Cited by this paper
  36. Icariin alleviates cognitive dysfunction by reducing neuroinflammation via the cGAS-STING pathway · Fengjuan Lu · 2025 · 21 citations · Cited by this paper
  37. Deletion of Pyruvate Carboxylase in Tubular Epithelial Cell Promotes Renal Fibrosis by Regulating SQOR/cGAS/STING‐Mediated Glycolysis · Hao Huang · 2025 · 20 citations · Cited by this paper
  38. Renal tubular in TCE-sensitization-induced immune kidney injury: Role of mitochondrial DNA in activating the cGAS-STING signaling pathway · Jinru Ma · 2022 · 18 citations · Cited by this paper
  39. Huangqi-Danshen decoction alleviates renal fibrosis through targeting SCD1 to modulate cGAS/STING signaling · Peng Yu · 2025 · 16 citations · Cited by this paper

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