Research map: The Biphasic Immune Pattern of Sepsis: From Pathophysiological Mechanisms to Precision Immunotherapy and Future Challenges

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  1. Sepsis-Induced Immunosuppression · Lisa K. Torres · 2021 · 368 citations · Cited by this paper
  2. Dry Cupping Therapy for Neck Pain: Monitoring for Adverse Effects · 2025 · Related
  3. The roles of macrophage polarization in the host immune response to sepsis · Xinsen Chen · 2021 · 292 citations · Cited by this paper
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  5. Human Myeloid-derived Suppressor Cells are Associated With Chronic Immune Suppression After Severe Sepsis/Septic Shock · Brittany J. Mathias · 2016 · 284 citations · Cited by this paper
  6. Sepsis-Associated Muscle Wasting: Mechanisms, Therapeutic Strategies, and the Role of Traditional Chinese Medicine · 2025 · Related
  7. The role of macrophages polarization in sepsis-induced acute lung injury · Ziyi Wang · 2023 · 212 citations · Cited by this paper
  8. Characterization of Canine Peripheral Blood Stem Cells After Electroacupuncture Stimulation · 2026 · Related
  9. Metabolic reprogramming consequences of sepsis: adaptations and contradictions · Jingjing Liu · 2022 · 153 citations · Cited by this paper
  10. Genomic Data into Traditional Korean Medicine: A Comprehensive Review · 2025 · Related
  11. Epigenetic mechanisms of Immune remodeling in sepsis: targeting histone modification · Dan Wu · 2023 · 126 citations · Cited by this paper
  12. Effectiveness of Hyeoldanggaesun-Tang in Patients with Type 2 Diabetes: A Retrospective Chart Study · 2026 · Related
  13. Single-cell RNA sequencing reveals the sustained immune cell dysfunction in the pathogenesis of sepsis secondary to bacterial pneumonia · Teng Wang · 2021 · 97 citations · Cited by this paper
  14. Exploring the Applicable Parts of Thumb and Middle Finger Measurements Based on Different Methods of Locating Acupuncture Points · 2026 · Related
  15. MDSCs in sepsis-induced immunosuppression and its potential therapeutic targets · Wanying Zhang · 2022 · 92 citations · Cited by this paper
  16. Diversity of Natural Medicines · 2026 · Related
  17. Lipid and Lipoprotein Dysregulation in Sepsis: Clinical and Mechanistic Insights into Chronic Critical Illness · Grant Barker · 2021 · 86 citations · Cited by this paper
  18. Evaluation of a Korean Medicine Hypertension Program in a Public Health Center: A Retrospective Observational Study · 2025 · Related
  19. Precision Immunotherapy to Improve Sepsis Outcomes · Evangelos J. Giamarellos‐Bourboulis · 2025 · 84 citations · Cited by this paper
  20. Efficacy of Piper Longum Extract in a Streptozotocin-Induced Mouse Model of Sporadic Alzheimer’s Disease Combined with Chronic Restraint Through Lipocalin-2-Associated Neuroinflammatory Mechanism · 2025 · Related
  21. The Regulatory Role of High-Mobility Group Protein 1 in Sepsis-Related Immunity · Li Li · 2021 · 46 citations · Cited by this paper
  22. Angiotensin II enhances bacterial clearance via myeloid signaling in a murine sepsis model · Daniel E. Leisman · 2022 · 46 citations · Cited by this paper
  23. Immune-cell signatures of persistent inflammation, immunosuppression, and catabolism syndrome after sepsis · Xingfeng Sun · 2025 · 41 citations · Cited by this paper
  24. Unraveling immunosenescence in sepsis: from cellular mechanisms to therapeutics · Yanghanzhao Wang · 2025 · 36 citations · Cited by this paper
  25. Advances in the Study of Immunosuppressive Mechanisms in Sepsis · Xu-zhe Fu · 2023 · 32 citations · Cited by this paper
  26. Glucose metabolism is upregulated in the mononuclear cell proteome during sepsis and supports endotoxin-tolerant cell function · Bianca Lima Ferreira · 2022 · 31 citations · Cited by this paper
  27. Immunotherapy in the context of sepsis-induced immunological dysregulation · Yiqi Wu · 2024 · 25 citations · Cited by this paper
  28. Immune dysregulation and RNA N6 ‐methyladenosine modification in sepsis · Hongyan Chen · 2022 · 24 citations · Cited by this paper
  29. Single-cell landscape of immunological responses in elderly patients with sepsis · Wanxue He · 2024 · 23 citations · Cited by this paper
  30. Single-cell multi-omic landscape reveals anatomical-specific immune features in adult and pediatric sepsis · Qian Ye · 2025 · 22 citations · Cited by this paper
  31. Unveiling the research advances of sepsis: pathogenesis, precise intervention and clinical perspective · Lingxia Cheng · 2025 · 18 citations · Cited by this paper
  32. Early Prediction for Persistent Inflammation-Immunosuppression Catabolism Syndrome in Surgical Sepsis Patients · Ming Zhong · 2021 · 16 citations · Cited by this paper
  33. Nanoplatforms in sepsis storm: Multimodal synergy for precision immunomodulation and pathogen neutralizations · Xinxin Wang · 2025 · 14 citations · Cited by this paper
  34. Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies · Yuhui Ma · 2025 · 14 citations · Cited by this paper
  35. Huang-Lian-Jie-Du decoction ameliorates sepsis through dynamic regulation of immune response and gut microbiota-metabolite axis · Qi Zheng · 2024 · 11 citations · Cited by this paper
  36. Research Progress on the Immune Function of Liver Sinusoidal Endothelial Cells in Sepsis · Xinrui Wang · 2025 · 11 citations · Cited by this paper
  37. S100A9 in sepsis: A biomarker for inflammation and a mediator of organ damage · Jinlian Xu · 2025 · 7 citations · Cited by this paper
  38. Damage-associated Molecular Patterns, Immunothrombosis, and Intravascular Inflammation in Sepsis: A Narrative Integrative Review · Toshiaki Iba · 2025 · 7 citations · Cited by this paper
  39. Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illness · Evan L. Barrios · 2024 · 6 citations · Cited by this paper

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