Research map: Altered myelin sphingolipid and glycerophospholipid profiles in Huntington disease

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Papers in this map

  1. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes · Marcy E. MacDonald · 1993 · 8490 citations · Cited by this paper
  2. Multimodal MRI integrating anti-motion multi-parametric mappings for investigating subcortical nuclei microstructural alterations in Huntington's disease · 2026 · Related
  3. The Biology of Huntingtin · Frédéric Saudou · 2016 · 1019 citations · Cited by this paper
  4. Effects of computerized cognitive training on functional activity and connectivity in Huntington's disease: A pilot study · 2025 · Related
  5. Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data · Sarah J. Tabrizi · 2009 · 990 citations · Cited by this paper
  6. Mapping the landscape of caregiver burden in Huntington's Disease: Current evidence and future directions · 2025 · Related
  7. Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures · Gerhard Liebisch · 2020 · 931 citations · Cited by this paper
  8. Prevention of appearance of severe Huntington's disease symptoms in the R6/1 mouse model by early administration of 4′,5,7-trihydroxyisoflavone · 2026 · Related
  9. Fourteen and counting: unraveling trinucleotide repeat diseases · Christopher J. Cummings · 2000 · 460 citations · Cited by this paper
  10. Phase-targeted auditory stimulation enhances slow-wave activity during sleep in Huntington's disease: A pilot crossover study · 2026 · Related
  11. Myelin Fat Facts: An Overview of Lipids and Fatty Acid Metabolism · Yannick Poitelon · 2020 · 407 citations · Cited by this paper
  12. Understanding the relationship between patient-reported outcome measures, clinician-rated assessments, and performance-based measures (cognitive tests and device-based estimates) of symptoms and functioning in people with Huntington's disease · 2025 · Related
  13. Diffusion tensor imaging in presymptomatic and early Huntington's disease: Selective white matter pathology and its relationship to clinical measures · Herminia Diana Rosas · 2006 · 347 citations · Cited by this paper
  14. Contribution of neuroepigenetics to HD – developmental and aging-related signatures · 2026 · Related
  15. Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models · Roman Chrast · 2010 · 321 citations · Cited by this paper
  16. Dysregulated astrocyte cholesterol synthesis in Huntington's disease: A potential intersection with other cellular dysfunctions · 2025 · Related
  17. Regional Specificity of Brain Atrophy in Huntington's Disease · Glenda Margaret Halliday · 1998 · 275 citations · Cited by this paper
  18. Insights into neurodevelopmental features of Huntington's disease from stem cell-derived models including organoids · 2025 · Related
  19. Progression of Symptoms in the Early and Middle Stages of Huntington Disease · Sandra Close Kirkwood · 2001 · 271 citations · Cited by this paper
  20. Psychosis in Huntington's disease: A case supporting multidisciplinary and early palliative care · 2026 · Related
  21. Longitudinal change in regional brain volumes in prodromal Huntington disease · Elizabeth Aylward · 2010 · 256 citations · Cited by this paper
  22. Decreased Neuronal and Increased Oligodendroglial Densities in Huntington's Disease Caudate Nucleus · Richard H. Myers · 1991 · 244 citations · Cited by this paper
  23. Mutant Huntingtin Downregulates Myelin Regulatory Factor-Mediated Myelin Gene Expression and Affects Mature Oligodendrocytes · Brenda Huang · 2015 · 190 citations · Cited by this paper
  24. The HTT CAG-Expansion Mutation Determines Age at Death but Not Disease Duration in Huntington Disease · Jae Whan Keum · 2016 · 167 citations · Cited by this paper
  25. LIPID COMPOSITION OF MYELIN FROM THE PERIPHERAL NERVOUS SYSTEM · John S. O’Brien · 1967 · 143 citations · Cited by this paper
  26. Ablation of Neuronal Ceramide Synthase 1 in Mice Decreases Ganglioside Levels and Expression of Myelin-associated Glycoprotein in Oligodendrocytes · Christina Ginkel · 2012 · 141 citations · Cited by this paper
  27. Fatty acid composition of human brain sphingomyelins: normal variation with age and changes during myelin disorders · Stina Ställberg-Stenhagen · 1965 · 130 citations · Cited by this paper
  28. Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease · Costanza Ferrari Bardile · 2019 · 127 citations · Cited by this paper
  29. Lipidome atlas of the adult human brain · Maria Osetrova · 2024 · 120 citations · Cited by this paper
  30. Myelin lipid metabolism and its role in myelination and myelin maintenance · Joseph A. Barnes-Vélez · 2022 · 116 citations · Cited by this paper
  31. Chemical Derivatization and Ultrahigh Resolution and Accurate Mass Spectrometry Strategies for “Shotgun” Lipidome Analysis · Eileen Ryan · 2016 · 112 citations · Cited by this paper
  32. White matter connectivity reflects clinical and cognitive status in Huntington's disease · Govinda Raj Poudel · 2014 · 104 citations · Cited by this paper
  33. Regional Distribution and Clinical Correlates of White Matter Structural Damage in Huntington Disease: A Tract-Based Spatial Statistics Study · Riccardo Della Nave · 2010 · 100 citations · Cited by this paper
  34. Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease · Jing Jin · 2015 · 94 citations · Cited by this paper
  35. The biophysical properties of ethanolamine plasmalogens revealed by atomistic molecular dynamics simulations · Tomasz Róg · 2015 · 91 citations · Cited by this paper
  36. Evidence for altered cholesterol metabolism in H untington's disease post mortem brain tissue · Fabian Kreilaus · 2015 · 90 citations · Cited by this paper
  37. Major Superficial White Matter Abnormalities in Huntington's Disease · Owen Robert Phillips · 2016 · 83 citations · Cited by this paper
  38. Myelin Breakdown in Human Huntington’s Disease: Multi-Modal Evidence from Diffusion MRI and Quantitative Magnetization Transfer · José Bourbon‐Teles · 2017 · 80 citations · Cited by this paper
  39. Myelin: Methods for Purification and Proteome Analysis · Michelle S Erwig · 2019 · 63 citations · Cited by this paper

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