Research map: Faecal proteases and immune signatures drive subtype-specific enteric neuronal activation in IBS

Back to the article

Papers in this map

  1. A dual thrombin receptor system for platelet activation · Mark L. Kahn · 1998 · 990 citations · Cited by this paper
  2. Modulation of the microbiota–enteric nervous system axis by environmental factors: from adaptive plasticity to maladaptive neuroenteric remodeling · Gemma Mazzuoli‐Weber · 2026 · Cites this paper
  3. A patient-driven agenda for liver cirrhosis research · 2026 · Related
  4. Intestinal microbiota in functional bowel disorders: a Rome foundation report · Magnus Simrén · 2012 · 948 citations · Cited by this paper
  5. International consensus on intestinal epithelial barrier assessment and therapeutic effects in inflammatory bowel diseases clinical trials · 2026 · Related
  6. Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis · Priya Oka · 2020 · 880 citations · Cited by this paper
  7. Toward a CKLM framework for integrated clinical trial design · 2026 · Related
  8. Role for protease activity in visceral pain in irritable bowel syndrome · Nicolas Cénac · 2007 · 590 citations · Cited by this paper
  9. Large language models for detecting colorectal polyps in endoscopic images—further research is required · 2026 · Related
  10. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial · Wendy Atkinson · 2004 · 539 citations · Cited by this paper
  11. USP20 promotes CD8 + T cell exhaustion and impairs KRAS G12D inhibitor efficacy by orchestrating cholesterol metabolism and autophagy in pancreatic cancer · 2026 · Related
  12. Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators · Thierry Piche · 2008 · 534 citations · Cited by this paper
  13. Galectin-14, a primate-specific oncofetal protein, impairs anti-tumour immunity in hepatocellular carcinoma by driving elevated heparan sulphate modification · 2026 · Related
  14. Short-Chain Fatty Acids Regulate the Enteric Neurons and Control Gastrointestinal Motility in Rats · Rodolphe Soret · 2010 · 532 citations · Cited by this paper
  15. Cancer neuroscience in cholangiocarcinoma: from perineural invasion to neuroimmune control · 2026 · Related
  16. Human Neonatal Fc Receptor Mediates Transport of IgG into Luminal Secretions for Delivery of Antigens to Mucosal Dendritic Cells · Masaru Yoshida · 2004 · 473 citations · Cited by this paper
  17. Cryptogenic steatotic liver disease: a lean phenotype associated with increased liver-related mortality · 2026 · Related
  18. Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases · Dorothea M. Heuberger · 2019 · 384 citations · Cited by this paper
  19. Safety and efficacy of extended surveillance intervals following colorectal endoscopic submucosal dissection: an international multicentre study · 2026 · Related
  20. Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome · QiQi Zhou · 2009 · 369 citations · Cited by this paper
  21. Endosomal signalling of protease-activated receptor-2 amplifies histamine-induced pain of irritable bowel syndrome · 2026 · Related
  22. The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice · Farzad Alemi · 2012 · 360 citations · Cited by this paper
  23. Activation of Human Enteric Neurons by Supernatants of Colonic Biopsy Specimens From Patients With Irritable Bowel Syndrome · Sabine Bühner · 2009 · 348 citations · Cited by this paper
  24. Confocal Endomicroscopy Shows Food-Associated Changes in the Intestinal Mucosa of Patients With Irritable Bowel Syndrome · Annette Fritscher‐Ravens · 2014 · 328 citations · Cited by this paper
  25. Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity · Krisztina Barbara Gecse · 2008 · 316 citations · Cited by this paper
  26. The Expression and the Cellular Distribution of the Tight Junction Proteins Are Altered in Irritable Bowel Syndrome Patients With Differences According to the Disease Subtype · Nathalie Bertiaux-Vandaële · 2011 · 295 citations · Cited by this paper
  27. Structural insight into allosteric modulation of protease-activated receptor 2 · Robert K. Y. Cheng · 2017 · 258 citations · Cited by this paper
  28. Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis · Clara Moon · 2013 · 243 citations · Cited by this paper
  29. Protease inhibition as new therapeutic strategy for GI diseases · Nathalie Vergnolle · 2016 · 230 citations · Cited by this paper
  30. The human enteric nervous system · Michael Schemann · 2004 · 213 citations · Cited by this paper
  31. Physical and Psychological Stress in Rats Enhances Colonic Epithelial Permeability via Peripheral CRH · Paul Richard Saunders · 2002 · 196 citations · Cited by this paper
  32. Regulation of intestinal permeability: The role of proteases · Hanne Van Spaendonk · 2017 · 190 citations · Cited by this paper
  33. New treatments and therapeutic targets for IBS and other functional bowel disorders · Magnus Simrén · 2018 · 143 citations · Cited by this paper
  34. A Pilot Study of Fecal Serine-Protease Activity: A Pathophysiologic Factor in Diarrhea-Predominant Irritable Bowel Syndrome · R Róka · 2007 · 131 citations · Cited by this paper
  35. Epithelial expression and function of trypsin-3 in irritable bowel syndrome · Claire Rolland-Fourcade · 2017 · 127 citations · Cited by this paper
  36. Bacterial proteases in IBD and IBS · Natalie Steck · 2011 · 125 citations · Cited by this paper
  37. Gut microbiome signatures reflect different subtypes of irritable bowel syndrome · Qi Su · 2022 · 116 citations · Cited by this paper
  38. Serine proteases as luminal mediators of intestinal barrier dysfunction and symptom severity in IBS · Shoko Edogawa · 2019 · 103 citations · Cited by this paper
  39. Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome · Adam L. Edwinson · 2022 · 103 citations · Cited by this paper

Source: OpenAlex (CC0)