Research map: Development of ganciclovir as an anti-human cytomegalovirus drug: historical perspectives and future prospects

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Papers in this map

  1. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine · Gertrude B. Elion · 1977 · 1596 citations · Cited by this paper
  2. Environmental samples, a sensitive and practical alternative to individual bird sampling in the surveillance of H9N2 vaccinated turkey flocks · 2026 · Related
  3. 9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group · H. J. Schaeffer · 1978 · 1140 citations · Cited by this paper
  4. The MNV-1 protease–polymerase precursor cleaves a novel site in the NS1-2 protein · 2026 · Related
  5. Estimation of the worldwide seroprevalence of cytomegalovirus: A systematic review and meta‐analysis · Mohamed Zuhair · 2019 · 935 citations · Cited by this paper
  6. Human pegivirus, Toscana virus and herpesviruses identified in cerebrospinal fluid from adults with unexplained neurologic disease, Spain, 2022–2023 · 2026 · Related
  7. Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease · David Winston Kimberlin · 2015 · 829 citations · Cited by this paper
  8. Quantitation of cytopathic honey bee viruses using the viral plaque assay method · 2026 · Related
  9. Pathogenesis of human cytomegalovirus in the immunocompromised host · Paul Griffiths · 2021 · 650 citations · Cited by this paper
  10. ICTV Virus Taxonomy Profile: Konkoviridae 2026 · 2026 · Related
  11. Antiviral Drug Resistance of Human Cytomegalovirus · Nell S. Lurain · 2010 · 603 citations · Cited by this paper
  12. Structural insights into the nuclear import of ovine gammaherpesvirus 2 ORF73 LANA homologue · 2026 · Related
  13. Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines · Erik De Clercq · 1987 · 519 citations · Cited by this paper
  14. Conserved histidine residues and the control of tick-borne encephalitis virus maturation · 2026 · Related
  15. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells · Veronica Sullivan · 1992 · 475 citations · Cited by this paper
  16. Evolutionary and taxonomic insights into the genomic divergence of cowpea mild mottle virus: rapid evolution in replication-associated protein gene, but strong negative selection on coat protein gene · 2026 · Related
  17. Treatment of Serious Cytomegalovirus Infections with 9-(1,3-Dihydroxy-2-Propoxymethyl)Guanine in Patients with AIDS and Other Immunodeficiencies · Collaborative DHPG Treatment Study Group · 1986 · 430 citations · Cited by this paper
  18. Infectivity of recombinant Torque teno sus virus 1 in pigs coinfected with swine influenza virus · 2026 · Related
  19. Ganciclovir · Clyde S. Crumpacker · 1996 · 385 citations · Cited by this paper
  20. Double-edged sword: flavivirus NS1 enhances human plasmin-mediated fibrinolysis while being targeted for cleavage and inactivation · 2026 · Related
  21. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine: a new potent and selective antiherpes agent · John C Martin · 1983 · 342 citations · Cited by this paper
  22. Valaciclovir to prevent vertical transmission of cytomegalovirus after maternal primary infection during pregnancy: a randomised, double-blind, placebo-controlled trial · Keren Shahar‐Nissan · 2020 · 299 citations · Cited by this paper
  23. Growth Inhibition by Acycloguanosine of Herpesviruses Isolated from Human Infections · Clyde S. Crumpacker · 1979 · 275 citations · Cited by this paper
  24. Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases · Christian P. Beltinger · 1999 · 201 citations · Cited by this paper
  25. Consensus recommendation for prenatal, neonatal and postnatal management of congenital cytomegalovirus infection from the European congenital infection initiative (ECCI) · Marianne Leruez‐Ville · 2024 · 186 citations · Cited by this paper
  26. Antiherpesvirus drugs: a promising spectrum of new drugs and drug targets · Donald M. Coen · 2003 · 170 citations · Cited by this paper
  27. Single‐Dose Pharmacokinetics of Valganciclovir in HIV‐ and CMV‐Seropositive Subjects · Donald T. Jung · 1999 · 169 citations · Cited by this paper
  28. Phosphorylation of acyclovir diphosphate by cellular enzymes · Wayne H. Miller · 1982 · 138 citations · Cited by this paper
  29. Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxymethyl) guanine and acyclovir in herpes simplex virus-infected and uninfected cells · Donald F. Smee · 1985 · 131 citations · Cited by this paper
  30. Insertion and extension of acyclic, dideoxy, and ara nucleotides by herpesviridae, human alpha and human beta polymerases. A unique inhibition mechanism for 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate. · Richard J. Reid · 1988 · 113 citations · Cited by this paper
  31. Effect of Adenine Arabinoside on Cytomegalovims Infections · L. T. Ch'ien · 1974 · 109 citations · Cited by this paper
  32. Cytoplasmic 5'-nucleotidase catalyzes acyclovir phosphorylation. · Paul Malcolm Keller · 1985 · 88 citations · Cited by this paper
  33. Mechanism of ganciclovir-induced chain termination revealed by resistant viral polymerase mutants with reduced exonuclease activity · Han Chen · 2014 · 54 citations · Cited by this paper
  34. The phosphotransferase activity of cytosolic 5′-nucleotidase; a purine analog phosphorylating enzyme · S Banditelli · 1996 · 41 citations · Cited by this paper
  35. The direct and indirect consequences of cytomegalovirus infection and potential benefits of vaccination · Paul Griffiths · 2020 · 40 citations · Cited by this paper
  36. Assessing the risk of adverse pregnancy outcomes and birth defects reporting in women exposed to ganciclovir or valganciclovir during pregnancy: a pharmacovigilance study · Adrien Contejean · 2023 · 27 citations · Cited by this paper
  37. NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir · Si Min Zhang · 2021 · 25 citations · Cited by this paper
  38. NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir · Rina Nishii · 2021 · 25 citations · Cited by this paper
  39. Compassionate Use: A Story of Ethics and Science in the Development of a New Drug · William C. Buhles · 2011 · 24 citations · Cited by this paper

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