Research map: The role and mechanisms of the cGAS-STING signaling pathway in age-related pathophysiological processes: challenges and therapeutic strategies

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  1. Accurate structure prediction of biomolecular interactions with AlphaFold 3 · Josh Abramson · 2024 · 16046 citations · Cited by this paper
  2. Role of the cGAS-STING signaling pathway in diabetes mellitus and its complications: from mechanisms to therapeutics · Guangdong Qi · 2026 · Cites this paper
  3. Mechanosensitive Yes-Associated Protein/TAZ–cGAS–STING Axis Induces Periodontal Ligament Fibroblasts Senescence and Mediates Compression-Induced Root Resorption · Zuping Wu · 2026 · 2 citations · Related
  4. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling · Hiroki Ishikawa · 2008 · 3600 citations · Cited by this paper
  5. Genetic polymorphisms of drug-metabolizing cytochromes P450 and flavin-containing monooxygenases in dogs and pigs inform the prediction of drug metabolism and toxicity in humans and other animal species · Yasuhiro Uno · 2026 · Related
  6. CB-Dock2: improved protein–ligand blind docking by integrating cavity detection, docking and homologous template fitting · Yang Liu · 2022 · 2075 citations · Cited by this paper
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  8. Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics · Shuai Jiang · 2024 · 1638 citations · Cited by this paper
  9. BiP-engaging xanthones from the mangosteen (Garcinia mangostana) induce androgen receptor degradation in prostate cancer cells · 2026 · Related
  10. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity · Leticia P. Corrales · 2015 · 1565 citations · Cited by this paper
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  12. The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation · Bo Zhong · 2008 · 1533 citations · Cited by this paper
  13. CerS2/ceramide C24:1/ROCK2 signaling-mediated angiogenesis protects against ischemic brain injury in mice · 2026 · Related
  14. cGAS–STING drives ageing-related inflammation and neurodegeneration · Muhammet Fatih Gulen · 2023 · 1061 citations · Cited by this paper
  15. Core genes drive treatment resistance in triple-negative breast cancer: characteristics, mechanisms, intervention strategies · 2026 · Related
  16. The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice · Junko Wakabayashi · 2009 · 693 citations · Cited by this paper
  17. cGAS-STING signaling in Alzheimer's disease: Microglial mechanisms and therapeutic opportunities · 2026 · Related
  18. Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway · Jeonghan Kim · 2023 · 531 citations · Cited by this paper
  19. The central role of endoplasmic reticulum stress in Parkinson’s disease and targeted therapeutic strategies · 2026 · Related
  20. Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1 · Thaneas Prabakaran · 2018 · 507 citations · Cited by this paper
  21. Jinxinkang Granule Preserves Myocardial Function by Suppressing Cardiac Senescence Through the cGAS-STING Axis in a Pressure Overload Mouse Model of Heart Failure · 2026 · Related
  22. The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA · Bo Zhong · 2009 · 496 citations · Cited by this paper
  23. TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination · Jing Zhang · 2012 · 410 citations · Cited by this paper
  24. cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers · Christy Hong · 2022 · 384 citations · Cited by this paper
  25. YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING · Hanna Lucie Sladitschek‐Martens · 2022 · 363 citations · Cited by this paper
  26. New frontiers in the cGAS-STING intracellular DNA-sensing pathway · Steve Dvorkin · 2024 · 354 citations · Cited by this paper
  27. Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging · Juan Ignacio Jiménez‐Loygorri · 2024 · 350 citations · Cited by this paper
  28. Activation of innate immune cGAS-STING pathway contributes to Alzheimer’s pathogenesis in 5×FAD mice · Xiaochun Xie · 2023 · 304 citations · Cited by this paper
  29. A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis · Dan Zhang · 2022 · 291 citations · Cited by this paper
  30. Regulation of cGAS–STING signalling and its diversity of cellular outcomes · Zhengyin Zhang · 2025 · 265 citations · Cited by this paper
  31. USP13 negatively regulates antiviral responses by deubiquitinating STING · He Sun · 2017 · 208 citations · Cited by this paper
  32. Critical Role of the cGAS-STING Pathway in Doxorubicin-Induced Cardiotoxicity · Wei Luo · 2023 · 183 citations · Cited by this paper
  33. AMPK/SIRT1/PGC‐1α Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy · Junyang Chen · 2025 · 171 citations · Cited by this paper
  34. Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders · Yige Huang · 2023 · 163 citations · Cited by this paper
  35. Microbiota-derived lysophosphatidylcholine alleviates Alzheimer’s disease pathology via suppressing ferroptosis · Xu Zha · 2024 · 155 citations · Cited by this paper
  36. Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway · Ping Lai · 2025 · 152 citations · Cited by this paper
  37. The selective STING inhibitor H-151 preserves myocardial function and ameliorates cardiac fibrosis in murine myocardial infarction · Shiyu Hu · 2022 · 130 citations · Cited by this paper
  38. Chronic kidney disease-induced muscle atrophy: Molecular mechanisms and promising therapies · Kexin Wang · 2022 · 126 citations · Cited by this paper
  39. The cGAS-STING-YY1 axis accelerates progression of neurodegeneration in a mouse model of Parkinson’s disease via LCN2-dependent astrocyte senescence · Siyuan Jiang · 2023 · 121 citations · Cited by this paper

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