Research map: Addition of irinotecan to chemoradiotherapy as preoperative treatment for locally advanced rectal cancer (ARISTOTLE): a multicentre, open-label, phase 3, randomised controlled trial

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  1. A Proportional Hazards Model for the Subdistribution of a Competing Risk · Jason P. Fine · 1999 · 13928 citations · Cited by this paper
  2. Chemoradiotherapy intensification in rectal cancer: lessons from the ARISTOTLE trial · Emmanouil Fokas · 2026 · Cites this paper
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  14. Randomized Phase II Study of Neoadjuvant Combined-Modality Chemoradiation for Distal Rectal Cancer: Radiation Therapy Oncology Group Trial 0012 · Mohammed M. Mohiuddin · 2006 · 255 citations · Cited by this paper
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  16. Pathological complete response following pre-operative chemoradiotherapy in rectal cancer: analysis of phase II/III trials · Andrew G. J. Hartley · 2005 · 196 citations · Cited by this paper
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  18. Multicenter, Randomized, Phase III Trial of Neoadjuvant Chemoradiation With Capecitabine and Irinotecan Guided by UGT1A1 Status in Patients With Locally Advanced Rectal Cancer · Ji Ye Zhu · 2020 · 131 citations · Cited by this paper
  19. A phase II study of capecitabine and irinotecan in combination with concurrent pelvic radiotherapy (CapIri-RT) as neoadjuvant treatment of locally advanced rectal cancer · Frank Willeke · 2007 · 106 citations · Cited by this paper
  20. Phase I Trial of Capecitabine and Weekly Irinotecan in Combination With Radiotherapy for Neoadjuvant Therapy of Rectal Cancer · Ralf‐Dieter Hofheinz · 2005 · 100 citations · Cited by this paper
  21. A Phase II study of preoperative radiotherapy and concomitant weekly irinotecan in combination with protracted venous infusion 5-fluorouracil, for resectable locally advanced rectal cancer · Matilde Navarro · 2006 · 71 citations · Cited by this paper
  22. All You Need to Know About UGT1A1 Genetic Testing for Patients Treated With Irinotecan: A Practitioner-Friendly Guide · Spinel Karas · 2021 · 70 citations · Cited by this paper
  23. Preoperative Chemoradiotherapy Using Concurrent Capecitabine and Irinotecan in Magnetic Resonance Imaging–Defined Locally Advanced Rectal Cancer: Impact on Long-Term Clinical Outcomes · Simon Gollins · 2011 · 55 citations · Cited by this paper
  24. A phase I/II study of irinotecan when added to 5-fluorouracil and leucovorin and pelvic radiation in locally advanced rectal cancer: a Colorectal Clinical Oncology Group Study · Rob Glynne‐Jones · 2007 · 55 citations · Cited by this paper
  25. Preoperative Chemoradiation With Irinotecan and Capecitabine in Patients With Locally Advanced Resectable Rectal Cancer: Long-Term Results of a Phase II Study · Yong Sang Hong · 2010 · 44 citations · Cited by this paper
  26. Systematic review of treatment intensification using novel agents for chemoradiotherapy in rectal cancer · Rachael Elizabeth Clifford · 2018 · 36 citations · Cited by this paper
  27. Meta-analysis of oxaliplatin-based versus fluorouracil-based neoadjuvant chemoradiotherapy and adjuvant chemotherapy for locally advanced rectal cancer · Xingli Fu · 2017 · 32 citations · Cited by this paper
  28. Addition of Platinum Derivatives to Fluoropyrimidine-Based Neoadjuvant Chemoradiotherapy for Stage II/III Rectal Cancer: Systematic Review and Meta-Analysis · Felix Jakob Hüttner · 2019 · 30 citations · Cited by this paper
  29. Image-based consensus molecular subtyping in rectal cancer biopsies and response to neoadjuvant chemoradiotherapy · Maxime W. Lafarge · 2024 · 25 citations · Cited by this paper
  30. Irinotecan and radiosensitization in rectal cancer · Henrik Illum · 2010 · 24 citations · Cited by this paper
  31. Preoperative downstaging chemoradiation with concurrent irinotecan and capecitabine in MRI-defined locally advanced rectal cancer: a phase I trial (NWCOG-2) · Simon Gollins · 2009 · 24 citations · Cited by this paper
  32. Identification and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune infiltrate and TGFβ as key predictors · Enric Domingo · 2024 · 20 citations · Cited by this paper
  33. Is There a Benefit of Oxaliplatin in Combination with Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer? An Updated Meta-Analysis · Gaëtan Des Guetz · 2021 · 19 citations · Cited by this paper
  34. Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures · Umair Mahmood · 2024 · 9 citations · Cited by this paper
  35. Radiosensitizing Effects of Irinotecan versus Oxaliplatin Alone and in Combination with 5-Fluorouracil on Human Colorectal Cancer Cells · Bernd Frerker · 2023 · 7 citations · Cited by this paper
  36. Neoadjuvant chemoradiotherapy with capecitabine and irinotecan guided by UGT1A1 status in patients with locally advanced rectal cancer: 5‐year update of the CinClare trial · Zhen Zhang · 2025 · 3 citations · Cited by this paper

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