Research map: Breakthroughs in our molecular understanding of therapeutic targets for pulmonary hypertension

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Papers in this map

  1. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension · Marc Humbert · 2022 · 3985 citations · Cited by this paper
  2. Advancements in the molecular understanding of major depressive disorder uncovering novel targets with therapeutic promise: focus on recurrence of illness · 2025 · Related
  3. Bosentan Therapy for Pulmonary Arterial Hypertension · Lewis J. Rubin · 2002 · 2736 citations · Cited by this paper
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  11. Reversal of experimental pulmonary hypertension by PDGF inhibition · RALPH THEO SCHERMULY · 2005 · 1064 citations · Cited by this paper
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  13. Progressive Right Ventricular Dysfunction in Patients With Pulmonary Arterial Hypertension Responding to Therapy · Mariëlle Carolijn van de Veerdonk · 2011 · 855 citations · Cited by this paper
  14. Transient receptor potential (TRP) channels: an emerging therapeutic target for the treatment of cardiac hypertrophy · 2026 · Related
  15. Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension · Elaine Soon · 2010 · 826 citations · Cited by this paper
  16. Lipopolysaccharide-targeting treatments for multidrug-resistant Pseudomonas aeruginosa · 2026 · Related
  17. Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti–IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease · Norihiro Nishimoto · 2008 · 823 citations · Cited by this paper
  18. 5-FU in combination with PARP inhibitor ABT-888 deregulates MGMT-dependent mismatch repair (MMR) pathway in MMR-proficient colorectal cancer stem cells by modulating MGMT/PARP1/MSH6 complex · 2026 · Related
  19. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study · Graeme Jones · 2009 · 819 citations · Cited by this paper
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  21. Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension · Marius M. Hoeper · 2023 · 728 citations · Cited by this paper
  22. Interleukin-6 Overexpression Induces Pulmonary Hypertension · M. Kathryn Steiner · 2008 · 657 citations · Cited by this paper
  23. The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species · Evan A. Bordt · 2017 · 627 citations · Cited by this paper
  24. Sotatercept for the Treatment of Pulmonary Arterial Hypertension · Marc Humbert · 2021 · 617 citations · Cited by this paper
  25. Imatinib Mesylate as Add-on Therapy for Pulmonary Arterial Hypertension · Marius M. Hoeper · 2013 · 575 citations · Cited by this paper
  26. Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension · Lü Long · 2015 · 525 citations · Cited by this paper
  27. Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension · Glenn Marsboom · 2012 · 465 citations · Cited by this paper
  28. DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis · Linda M. Henricks · 2018 · 443 citations · Cited by this paper
  29. RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension · Rebecca R. Vanderpool · 2014 · 358 citations · Cited by this paper
  30. Rituximab-associated hepatitis B virus (HBV) reactivation in lymphoproliferative diseases: meta-analysis and examination of FDA safety reports · Andrew M. Evens · 2010 · 353 citations · Cited by this paper
  31. Safety of extended treatment with anakinra in patients with rheumatoid arthritis · R Fleischmann · 2006 · 309 citations · Cited by this paper
  32. Inhibition of hypoxia-inducible factor-2α in renal cell carcinoma with belzutifan: a phase 1 trial and biomarker analysis · Toni K. Choueiri · 2021 · 308 citations · Cited by this paper
  33. The right ventricle in pulmonary arterial hypertension · Robert Naeije · 2014 · 272 citations · Cited by this paper
  34. Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease · Stefan Schreiber · 2021 · 268 citations · Cited by this paper
  35. In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug · Rachel K. Hopper · 2016 · 245 citations · Cited by this paper
  36. Macrophage–NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension · Ruaa Al‐Qazazi · 2022 · 222 citations · Cited by this paper
  37. Vascular Receptor Autoantibodies in Pulmonary Arterial Hypertension Associated with Systemic Sclerosis · Mike Oliver Becker · 2014 · 203 citations · Cited by this paper
  38. Safety and Efficacy of B-Cell Depletion with Rituximab for the Treatment of Systemic Sclerosis–associated Pulmonary Arterial Hypertension: A Multicenter, Double-Blind, Randomized, Placebo-controlled Trial · Roham T. Zamanian · 2021 · 190 citations · Cited by this paper
  39. Lung 18F-Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Pulmonary Arterial Hypertension · Glenn Marsboom · 2012 · 181 citations · Cited by this paper

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