Research map: Targeting cellular senescence through nutritional senotherapeutics in brain aging and neurodegenerative diseases

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Papers in this map

  1. Hallmarks of aging: An expanding universe · Carlos López-Otı́n · 2023 · 6513 citations · Cited by this paper
  2. AgeViva Modulates Inflammatory Responses, Autophagy, and Mitochondrial Homeostasis in BV-2 Cells and C. elegans · Federica Armeli · 2026 · Cites this paper
  3. The lancet commission obesity categories, excess adiposity, and BMI discordance in urban Chinese adults: a cross-sectional survey in Beijing · 2026 · Related
  4. The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression · Jean‐Philippe Coppé · 2010 · 5342 citations · Cited by this paper
  5. Taste and odor metabolomics of Schisandra chinensis flesh and seeds: integration of sensory evaluation, electronic tongue, LC-QTOF-MS/MS, VirtualTaste, and HS-GC-IMS · 2026 · Related
  6. Cellular senescence: when bad things happen to good cells · Judith Campisi · 2007 · 4490 citations · Cited by this paper
  7. Stevia-derived sweeteners in reduced-sugar foods: formulation strategies, sensory optimization, nutritional evidence, and safety perspectives · 2026 · Related
  8. The blood-brain barrier: Bottleneck in brain drug development · William M. Pardridge · 2004 · 2810 citations · Cited by this paper
  9. Association of lipoprotein indices with 3-month functional outcome after ischemic stroke: a retrospective cohort study · 2026 · Related
  10. Senolytics improve physical function and increase lifespan in old age · Ming Xu · 2018 · 2357 citations · Cited by this paper
  11. Daily dietary patterns associated with Helicobacter pylori infection and eradication-related adverse events, but not eradication rate: a cross-sectional and prospective cohort study · 2026 · Related
  12. An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA · Marco Demaria · 2014 · 2080 citations · Cited by this paper
  13. Surface defect detection method for shawo radishes based on improved RT-DETR · 2026 · Related
  14. Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype · Ruchi Kumari · 2021 · 1666 citations · Cited by this paper
  15. The risk factors and predictive nomogram for postoperative hypoalbuminemia in elderly patients undergoing hip arthroplasty · 2026 · Related
  16. Overviews of biological importance of quercetin: A bioactive flavonoid · Subramani Parasuraman · 2016 · 1632 citations · Cited by this paper
  17. Isocaloric substitution with beef and mutton and metabolically unhealthy obesity among adults in Ordos, Inner Mongolia: a cross-sectional analysis · 2026 · Related
  18. Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease · LaTonya J. Hickson · 2019 · 1379 citations · Cited by this paper
  19. Comparative metabolomics of high-unsaturated fatty acid oils: exploring volatile and nonvolatile metabolite differences in olive, walnut, flaxseed, and camellia oils · 2026 · Related
  20. Cellular senescence: the good, the bad and the unknown · Weijun Huang · 2022 · 1169 citations · Cited by this paper
  21. Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities · 2024 · Related
  22. Fisetin is a senotherapeutic that extends health and lifespan · Matthew J. Yousefzadeh · 2018 · 1044 citations · Cited by this paper
  23. Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model · Peisu Zhang · 2019 · 1014 citations · Cited by this paper
  24. Central nervous system pericytes in health and disease · Ethan A. Winkler · 2011 · 959 citations · Cited by this paper
  25. The therapeutic potential of resveratrol: a review of clinical trials · Adi Y. Berman · 2017 · 894 citations · Cited by this paper
  26. Human Adult Neurogenesis: Evidence and Remaining Questions · Gerd Kempermann · 2018 · 810 citations · Cited by this paper
  27. New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463 · Yi Zhun Zhu · 2017 · 760 citations · Cited by this paper
  28. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease · Raymond Scott Turner · 2015 · 737 citations · Cited by this paper
  29. Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease · Charbel Moussa · 2017 · 715 citations · Cited by this paper
  30. The blood-brain barrier: Physiology and strategies for drug delivery · Rucha Pandit · 2019 · 653 citations · Cited by this paper
  31. Targeting cellular senescence with senotherapeutics: senolytics and senomorphics · Lei Justan Zhang · 2022 · 621 citations · Cited by this paper
  32. Tau protein aggregation is associated with cellular senescence in the brain · Nicolas Musi · 2018 · 616 citations · Cited by this paper
  33. Postmitotic neurons develop a p21‐dependent senescence‐like phenotype driven by a DNA damage response · Diana Jurk · 2012 · 615 citations · Cited by this paper
  34. Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives · Darren J. Baker · 2018 · 517 citations · Cited by this paper
  35. Senescent cell clearance by the immune system: Emerging therapeutic opportunities · Larissa G. P. Langhi Prata · 2018 · 508 citations · Cited by this paper
  36. Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice · Emanuel J. Novais · 2021 · 456 citations · Cited by this paper
  37. Identification and characterization of Cardiac Glycosides as senolytic compounds · Francisco Triana-Martínez · 2019 · 390 citations · Cited by this paper
  38. The role of curcumin in aging and senescence: Molecular mechanisms · Aliabbas Zia · 2020 · 380 citations · Cited by this paper
  39. Blood–Brain Barrier Dynamics to Maintain Brain Homeostasis · Marta Segarra · 2021 · 307 citations · Cited by this paper

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