Research map: Increased ureagenesis revealing metabolic intolerance to enhanced nutrition in the PICU: a secondary analysis of the PEPaNIC RCT

Back to the article

Papers in this map

  1. Early versus Late Parenteral Nutrition in Critically Ill Adults · Michael Paul Casaer · 2011 · 1705 citations · Cited by this paper
  2. Dosing of anti-infective drugs in patients undergoing therapeutic plasma exchange – considerations for practical application: a narrative review · Maj-Britt Nachtigall · 2026 · Related
  3. Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study · Stéphane Leteurtre · 2003 · 748 citations · Cited by this paper
  4. Harmonizing the diagnosis of citrate accumulation - a call for standardized criteria · 2026 · Related
  5. Early versus Late Parenteral Nutrition in Critically Ill Children · Tom Fivez · 2016 · 571 citations · Cited by this paper
  6. Fluid-intolerance signals as bedside safety limits during early septic shock resuscitation: a multicenter randomized trial · 2026 · Related
  7. Paediatric Index of Mortality 3 · Lahn D. Straney · 2013 · 506 citations · Cited by this paper
  8. Palliative and end-of-life care on the battlefield: a scoping review · 2026 · Related
  9. Dutch national survey to test the STRONGkids nutritional risk screening tool in hospitalized children · Jessie M. Hulst · 2009 · 436 citations · Cited by this paper
  10. Eligibility criteria in sepsis-associated AKI trials preferentially exclude patients at risk to develop adverse kidney outcomes · 2026 · Related
  11. The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial · Daren Keith Heyland · 2023 · 395 citations · Cited by this paper
  12. The evolution of ECCO₂R: rethinking pump selection · 2025 · Related
  13. Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial · Greet Hermans · 2013 · 368 citations · Cited by this paper
  14. Beyond macrocirculatory targets: a multimodal framework for microcirculatory and organ perfusion monitoring in sepsis · 2026 · Related
  15. Role of Disease and Macronutrient Dose in the Randomized Controlled EPaNIC Trial · Michael Paul Casaer · 2012 · 321 citations · Cited by this paper
  16. Transpulmonary pressures and EIT-derived alveolar collapse and overdistension in ARDS: association and comparison of two PEEP titration strategies · 2026 · Related
  17. Insufficient Activation of Autophagy Allows Cellular Damage to Accumulate in Critically Ill Patients · Ilse Vanhorebeek · 2011 · 240 citations · Cited by this paper
  18. Intravenous amino acid therapy for kidney function in critically ill patients: a randomized controlled trial · Gordon Stuart Doig · 2015 · 238 citations · Cited by this paper
  19. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Energy · Koen Joosten · 2018 · 236 citations · Cited by this paper
  20. Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands · Julia L.M. Bels · 2024 · 165 citations · Cited by this paper
  21. Effect of early supplemental parenteral nutrition in the paediatric ICU: a preplanned observational study of post-randomisation treatments in the PEPaNIC trial · Ilse Vanhorebeek · 2017 · 163 citations · Cited by this paper
  22. Impact of Early Parenteral Nutrition on Metabolism and Kidney Injury · Jan Gunst · 2013 · 117 citations · Cited by this paper
  23. Early versus late parenteral nutrition in critically ill, term neonates: a preplanned secondary subgroup analysis of the PEPaNIC multicentre, randomised controlled trial · Esther van Puffelen · 2018 · 106 citations · Cited by this paper
  24. Impact of withholding early parenteral nutrition completing enteral nutrition in pediatric critically ill patients (PEPaNIC trial): study protocol for a randomized controlled trial · Tom Fivez · 2015 · 82 citations · Cited by this paper
  25. Latency, Duration and Dose Response Relationships of Amino Acid Effects on Human Muscle Protein Synthesis · Michael John Rennie · 2002 · 74 citations · Cited by this paper
  26. Outcomes of Delaying Parenteral Nutrition for 1 Week vs Initiation Within 24 Hours Among Undernourished Children in Pediatric Intensive Care · Esther van Puffelen · 2018 · 64 citations · Cited by this paper
  27. The urea-creatinine ratio as a novel biomarker of critical illness-associated catabolism · Jan Gunst · 2019 · 62 citations · Cited by this paper
  28. Association between urea trajectory and protein dose in critically ill adults: a secondary exploratory analysis of the effort protein trial (RE-EFFORT) · Ryan W. Haines · 2024 · 62 citations · Cited by this paper
  29. The urea-to-creatinine ratio as an emerging biomarker in critical care: a scoping review and meta-analysis · Michelle Carmen Paulus · 2025 · 60 citations · Cited by this paper
  30. Augmented Enteral Protein During Critical Illness · Matthew J. Summers · 2025 · 59 citations · Cited by this paper
  31. Catabolism in Critical Illness: A Reanalysis of the REducing Deaths due to OXidative Stress (REDOXS) Trial* · Ryan W. Haines · 2022 · 52 citations · Cited by this paper
  32. Parenteral Nutrition in Critically Ill Children · Nilesh M. Mehta · 2016 · 35 citations · Cited by this paper
  33. Biomarkers and kidney diseases: a brief narrative review · Mauricio Staib Younes-Ibrahim · 2022 · 23 citations · Cited by this paper
  34. On how to feed critically ill children in intensive care: A slowly shifting paradigm · Jan Gunst · 2025 · 13 citations · Cited by this paper
  35. The Urea–Creatinine Ratio as Marker of Catabolism Is Affected by Continuous Renal Replacement Therapy · Andreas Markl-Le Levé · 2025 · 8 citations · Cited by this paper
  36. Hypophosphatemia as a biomarker of metabolic intolerance to enhanced nutrition in the PICU: a secondary analysis of the PEPaNIC RCT · Ilse Vanhorebeek · 2026 · 2 citations · Cited by this paper

Source: OpenAlex (CC0)