Research map: TRIM9-Mediated Degradation of SMAD4 Promotes Pyroptosis and Disruption of the Endothelial Barrier in Aortic Dissection Disease

Back to the article

Papers in this map

  1. Shared Principles in NF-κB Signaling · Matthew S. Hayden · 2008 · 4841 citations · Cited by this paper
  2. Non-canonical PPARα Agonism by Arjunolic Acid Mitigates Cardiomyocyte PANoptosis Through a Novel PPARα/CRYAB/IKKα Axis During Pathological Cardiac Hypertrophy · 2026 · Related
  3. New insights into TGF-β/Smad signaling in tissue fibrosis · He-He Hu · 2018 · 1210 citations · Cited by this paper
  4. Interpretable Machine Learning in Heavy Metal-Associated Cardiovascular and Metabolic Disease: A Review of Current Methodologies, Toxicological Insights, and Clinical Implications · 2026 · Related
  5. Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes · Eduardo Bossone · 2020 · 490 citations · Cited by this paper
  6. Drug-Induced Noninfectious Myocarditis/Pericarditis: A Real-World Pharmacovigilance Study Using the FAERS Database · 2026 · Related
  7. Switching TGFβ from a tumor suppressor to a tumor promoter · Gareth J. Inman · 2011 · 195 citations · Cited by this paper
  8. Methyltransferase METTL1 Upregulates USF2 in a m7G-Dependent Manner to Accelerate Septic Cardiomyopathy by Inactivating PINK1/Parkin-Mediated Mitophagy · 2026 · Related
  9. 14-3-3ζ Turns TGF-β’s Function from Tumor Suppressor to Metastasis Promoter in Breast Cancer by Contextual Changes of Smad Partners from p53 to Gli2 · Jia Xu · 2015 · 186 citations · Cited by this paper
  10. Tnxb Alleviates Myocardial Ischemia-Reperfusion Injury Through Facilitating Akt-Dependent Endothelial Cell Survival and Angiogenesis in Mice · 2026 · Related
  11. Visualizing ubiquitination in mammalian cells · Sjoerd J. L. van Wijk · 2019 · 137 citations · Cited by this paper
  12. GLI1 Promotes Hypoxia Induced Pyroptosis of PASMCs and Aggravates Pulmonary Arterial Hypertension in Rats by Upregulating HDAC1 Expression · 2026 · Related
  13. TRIM47 is up-regulated in colorectal cancer, promoting ubiquitination and degradation of SMAD4 · Qian Liang · 2019 · 125 citations · Cited by this paper
  14. E-cigarette Aerosol Containing Nicotine Increases Aortic Stiffness in Young Mice · 2026 · Related
  15. Functional interactions between ubiquitin E2 enzymes and TRIM proteins · Luisa M. R. Napolitano · 2011 · 114 citations · Cited by this paper
  16. Microplastics and Nanoplastics in Cardiovascular Disease: An Emerging Cardiovascular Risk Factor · 2026 · Related
  17. Aortic dissection: medical, interventional and surgical management · Miriam Silaschi · 2016 · 108 citations · Cited by this paper
  18. Pioglitazone Mitigates Arsenic-Induced Cardiotoxicity via Lipid Metabolism: Network Pharmacology and Molecular Docking Approach · 2026 · Related
  19. Epidemiology of aortic dissection · Indrani Sen · 2021 · 102 citations · Cited by this paper
  20. Role of l-Arginine and Tetrahydrobiopterin in Attenuation of Vascular Ang1-8 Reactivity via Endothelial PI3K/AKT/eNOS Signaling Pathways in HgCl2-Induced Vascular Dysfunction. An Ex-Vivo Study · 2026 · Related
  21. TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies · Kunikazu Tanji · 2010 · 101 citations · Cited by this paper
  22. TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3β to TBK1 · Yunfei Qin · 2016 · 99 citations · Cited by this paper
  23. Posttranslational Regulation of Smads · Pinglong Xu · 2016 · 95 citations · Cited by this paper
  24. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice · Jianxiong Zeng · 2019 · 68 citations · Cited by this paper
  25. Research Progress on the Pathogenesis of Aortic Dissection · Zhiqiang Yin · 2022 · 65 citations · Cited by this paper
  26. Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates · Hai‐Tsang Huang · 2024 · 65 citations · Cited by this paper
  27. Cardiac fibroblast heat shock protein 47 aggravates cardiac fibrosis post myocardial ischemia–reperfusion injury by encouraging ubiquitin specific peptidase 10 dependent Smad4 deubiquitination · Saiyang Xie · 2022 · 59 citations · Cited by this paper
  28. Emerging Roles of TRIM8 in Health and Disease · Flaviana Marzano · 2021 · 55 citations · Cited by this paper
  29. Enhancing aortic valve drug delivery with PAR2-targeting magnetic nano-cargoes for calcification alleviation · Jinyong Chen · 2024 · 48 citations · Cited by this paper
  30. Modes of allosteric regulation of the ubiquitination machinery · Martin Luke Rennie · 2020 · 38 citations · Cited by this paper
  31. SMAD4 rare variants in individuals and families with thoracic aortic aneurysms and dissections · Xueyan Duan · 2019 · 34 citations · Cited by this paper
  32. Angiotensin II: Role in oxidative stress, endothelial dysfunction, and diseases · Amir Ajoolabady · 2024 · 32 citations · Cited by this paper
  33. Emerging Role of TRIM Family Proteins in Cardiovascular Disease · Jingrui Zhang · 2020 · 30 citations · Cited by this paper
  34. Atorvastatin prevents angiotensin II-induced high permeability of human arterial endothelial cell monolayers via ROCK signaling pathway · Yi Ren · 2015 · 29 citations · Cited by this paper
  35. A Functional Variant of SMAD4 Enhances Thoracic Aortic Aneurysm and Dissection Risk through Promoting Smooth Muscle Cell Apoptosis and Proteoglycan Degradation · Ying Wang · 2017 · 28 citations · Cited by this paper
  36. TRIM9 overexpression promotes uterine leiomyoma cell proliferation and inhibits cell apoptosis via NF-κB signaling pathway · Fang Yang · 2020 · 28 citations · Cited by this paper
  37. PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer · Ping Hui Gao · 2022 · 26 citations · Cited by this paper
  38. New classes of E3 ligases illuminated by chemical probes · Daniel Horn‐Ghetko · 2022 · 25 citations · Cited by this paper
  39. Research Progress on the Pathogenesis of Aortic Aneurysm and Dissection in Metabolism · Yihong Zhou · 2023 · 24 citations · Cited by this paper

Source: OpenAlex (CC0)