Research map: The Effect of Food and the Proton Pump Inhibitor Rabeprazole on Binimetinib Pharmacokinetics in Healthy Participants

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  1. Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal Cancer · Scott Kopetz · 2019 · 1507 citations · Cited by this paper
  2. Population Pharmacokinetics of Bosutinib in Children with Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia Based on a Phase I Dose-Finding Trial (ITCC-054/COG AAML1921) and Pediatric Recommended Phase II Dosage Evaluation · 2026 · Related
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  7. COMPARISON OF INHIBITORY EFFECTS OF THE PROTON PUMP-INHIBITING DRUGS OMEPRAZOLE, ESOMEPRAZOLE, LANSOPRAZOLE, PANTOPRAZOLE, AND RABEPRAZOLE ON HUMAN CYTOCHROME P450 ACTIVITIES · Xueqing Li · 2004 · 647 citations · Cited by this paper
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  10. A Review of Population Pharmacokinetic Models and Dosing Algorithms Assessing the Influence of CYP3A5 Genotype and Other Clinical Covariates on Tacrolimus Pharmacokinetics · 2026 · Related
  11. A Review of Food–Drug Interactions on Oral Drug Absorption · Jianyuan Deng · 2017 · 228 citations · Cited by this paper
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  13. Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review · Maria Vertzoni · 2019 · 223 citations · Cited by this paper
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  15. A phase 1 dose-escalation and expansion study of binimetinib (MEK162), a potent and selective oral MEK1/2 inhibitor · Johanna C. Bendell · 2017 · 137 citations · Cited by this paper
  16. Impacts of Uremic Toxins on the Population Pharmacokinetics of Total Mycophenolic Acid and its Glucuronide Metabolite in Adult Kidney Transplant Recipients · 2026 · Related
  17. Phase II, Open-Label Study of Encorafenib Plus Binimetinib in Patients With BRAFV600-Mutant Metastatic Non–Small-Cell Lung Cancer · Gregory J. Riely · 2023 · 126 citations · Cited by this paper
  18. Population Pharmacokinetics for Pediatric Extrapolation of GenSci006: A 3.75-mg Triptorelin Acetate Microsphere Formulation for Central Precocious Puberty · 2026 · Related
  19. Evaluation of Six Proton Pump Inhibitors As Inhibitors of Various Human Cytochromes P450: Focus on Cytochrome P450 2C19 · Tatyana A. Zvyaga · 2012 · 125 citations · Cited by this paper
  20. ALBI Grade is a Determinant of Lenvatinib Pharmacokinetics, Efficacy, and Toxicities in Japanese Patients with Hepatocellular Carcinoma · 2026 · Related
  21. A Systematic Review of Gastric Acid-Reducing Agent-Mediated Drug–Drug Interactions with Orally Administered Medications · Divya Patel · 2019 · 109 citations · Cited by this paper
  22. A Phase Ib/II Study of the BRAF Inhibitor Encorafenib Plus the MEK Inhibitor Binimetinib in Patients with BRAFV600E/K -mutant Solid Tumors · Ryan Joseph Sullivan · 2020 · 48 citations · Cited by this paper
  23. Supersaturation and Precipitation Applicated in Drug Delivery Systems: Development Strategies and Evaluation Approaches · Yanxiong Gan · 2023 · 48 citations · Cited by this paper
  24. A placebo‐controlled study to assess the effects of 7‐day dosing with 10, 20 and 40 mg rabeprazole on 24‐h intragastric acidity and plasma gastrin in healthy male subjects · Williams · 2000 · 45 citations · Cited by this paper
  25. Rabeprazole for the treatment of acid-related disorders · Silvia Marelli · 2012 · 38 citations · Cited by this paper
  26. A phase I study of binimetinib (MEK162) in Japanese patients with advanced solid tumors · Koichiro Watanabe · 2016 · 36 citations · Cited by this paper
  27. Binimetinib plus Gemcitabine and Cisplatin Phase I/II Trial in Patients with Advanced Biliary Cancers · Maeve Aine Lowery · 2018 · 36 citations · Cited by this paper
  28. Phase Ib Study of Binimetinib with Paclitaxel in Patients with Platinum-Resistant Ovarian Cancer: Final Results, Potential Biomarkers, and Extreme Responders · Rachel Nicole Grisham · 2018 · 32 citations · Cited by this paper
  29. Rabeprazole · Claudine M. Baldwin · 2009 · 29 citations · Cited by this paper
  30. Effect of food or proton pump inhibitor treatment on the bioavailability of dacomitinib in healthy volunteers · Ana Ruiz-Garcı́a · 2015 · 25 citations · Cited by this paper
  31. Effect of Food and a Proton-Pump Inhibitor on the Absorption of Encorafenib: An In Vivo–In Vitro–In Silico Approach · Joseph A. Piscitelli · 2023 · 22 citations · Cited by this paper
  32. Exploring the Relationship of Drug BCS Classification, Food Effect, and Gastric pH-Dependent Drug Interactions · Katie H. Owens · 2021 · 19 citations · Cited by this paper
  33. Dose–response relationships of rabeprazole 5, 10, 20, and 40 mg once daily on suppression of gastric acid secretion through the night in healthy Japanese individuals with different CYP2C19 genotypes · Seiichi Hayato · 2011 · 16 citations · Cited by this paper
  34. Pivotal Considerations for Optimal Deployment of Healthy Volunteers in Oncology Drug Development · Mariam Ahuoiza AHMED · 2019 · 14 citations · Cited by this paper
  35. Abstracts for the Ninth American Conference on Pharmacometrics (ACoP9) · Karanam, Ashwin · 2018 · 10 citations · Cited by this paper
  36. The Absorption, Distribution, Metabolism, and Excretion of Binimetinib Following a Single Oral Dose of [ 14C ]Binimetinib 45 mg in Healthy Male Participants · Dustin Huynh · 2025 · 2 citations · Cited by this paper
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