Research map: Germinal center and extrafollicular dysregulation in systemic lupus erythematosus: Mechanisms and therapeutic opportunities

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  1. Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme · Masamichi Muramatsu · 2000 · 3513 citations · Cited by this paper
  2. Rewiring immunometabolism in hepato-biliary-pancreatic cancers: Unraveling TME-mediated metabolic suppression and advancing next-generation immunotherapeutic approaches · 2026 · Related
  3. Predominant Autoantibody Production by Early Human B Cell Precursors · Hedda Wardemann · 2003 · 2123 citations · Cited by this paper
  4. Predicting the course: Real-world trajectories toward minimal disease activity in psoriatic arthritis · 2026 · Related
  5. Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets · Ryan D. Michalek · 2011 · 2111 citations · Cited by this paper
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  7. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial · Sandra Navarra · 2011 · 2099 citations · Cited by this paper
  8. Pathological reprogramming of innate immune cells drives resistance to biologics in inflammatory bowel diseases · 2026 · Related
  9. A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus · Richard Alan Furie · 2011 · 1694 citations · Cited by this paper
  10. Inflammatory biomarkers of atherosclerosis in SLE that may improve SLE-specific cardiovascular risk assessment tools · 2026 · Related
  11. Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation · Robert J. Johnston · 2009 · 1662 citations · Cited by this paper
  12. Iron, autoimmunity, and thrombosis: Exploring sex-specific interactions · 2026 · Related
  13. Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease · Christian Lood · 2016 · 1614 citations · Cited by this paper
  14. IL-17 and IL-21: Their Immunobiology and Therapeutic Potentials · 2024 · Related
  15. Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology · Eva Vanessa Schrezenmeier · 2020 · 1523 citations · Cited by this paper
  16. The application of low-carbohydrate diet in autoimmune diseases: Mechanisms, evidence, and prospects for clinical translation · 2026 · Related
  17. Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The lupus nephritis assessment with rituximab study · Brad H. Rovin · 2012 · 1471 citations · Cited by this paper
  18. Fatty acid oxidation and inflammatory bowel disease: Highlighting the roles of pathogenesis and treatment · 2026 · Related
  19. Mycophenolate mofetil and its mechanisms of action · ANTHONY C. ALLISON · 2000 · 1438 citations · Cited by this paper
  20. Germinal-centre and extrafollicular B cell pathways in systemic lupus erythematosus · 2026 · Related
  21. Efficacy and safety of rituximab in moderately‐to‐severely active systemic lupus erythematosus: The randomized, double‐blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial · Joan T. Merrill · 2009 · 1419 citations · Cited by this paper
  22. Trial of Anifrolumab in Active Systemic Lupus Erythematosus · Eric Francis Morand · 2019 · 1387 citations · Cited by this paper
  23. Foxp3+ follicular regulatory T cells control the germinal center response · Michelle A. Linterman · 2011 · 1311 citations · Cited by this paper
  24. Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments · Alessia Angelin · 2017 · 1256 citations · Cited by this paper
  25. Detection of Ectopic B‐cell Follicles with Germinal Centers in the Meninges of Patients with Secondary Progressive Multiple Sclerosis · Barbara Serafini · 2004 · 1225 citations · Cited by this paper
  26. Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis · Deepak A. Rao · 2017 · 1167 citations · Cited by this paper
  27. Mechanism and Regulation of Class Switch Recombination · Janet Stavnezer · 2008 · 1149 citations · Cited by this paper
  28. Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions · Yeonseok Chung · 2011 · 1147 citations · Cited by this paper
  29. Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus · Scott A. Jenks · 2018 · 1145 citations · Cited by this paper
  30. The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation · Tsutomu Kawabe · 1994 · 1112 citations · Cited by this paper
  31. Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus · Andréas Mackensen · 2022 · 1101 citations · Cited by this paper
  32. CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up · Fabian Müller · 2024 · 1085 citations · Cited by this paper
  33. EULAR recommendations for the management of systemic lupus erythematosus: 2023 update · Antonis Fanouriakis · 2023 · 1063 citations · Cited by this paper
  34. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors · Peter S. Linsley · 1994 · 986 citations · Cited by this paper
  35. Cracking the BAFF code · Fabienne Mackay · 2009 · 935 citations · Cited by this paper
  36. SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses · Jackson S. Turner · 2021 · 902 citations · Cited by this paper
  37. The immune cell landscape in kidneys of patients with lupus nephritis · the Accelerating Medicines Partnership in SLE network · 2019 · 870 citations · Cited by this paper
  38. Germinal Centers · Gabriel D. Victora · 2022 · 865 citations · Cited by this paper
  39. Cytokine-secreting follicular T cells shape the antibody repertoire · Richard Lee Reinhardt · 2009 · 833 citations · Cited by this paper

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