Research map: Engineered microorganisms and nanomaterials in cancer therapy: Emerging hybrid systems and translational challenges

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Papers in this map

  1. Cancer nanomedicine: progress, challenges and opportunities · Jinjun Shi · 2016 · 5850 citations · Cited by this paper
  2. Superparamagnetic core-shell nanoparticles enable co-delivery of psoralen and paclitaxel for the treatment of triple-negative breast cancer · 2026 · Related
  3. Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy · Ta-Chung Yu · 2017 · 2279 citations · Cited by this paper
  4. Mitochondrial preservation underlies the antioxidant activity of nanoceria particles in light-induced retinal degeneration · 2026 · Related
  5. Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer · Shinichi Yachida · 2019 · 1529 citations · Cited by this paper
  6. Fluvastatin-loaded chitosan-coated transfersomes for tumor-targeted nanotheranostics: Optimization, in-vitro cytotoxicity, and in-vivo radiokinetic evaluation · 2026 · Related
  7. Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors · Jonathan M. Pitt · 2016 · 1078 citations · Cited by this paper
  8. Regenerative polymer-based modalities for diabetic foot ulcers: From material design to clinical translation · 2026 · Related
  9. Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization · Susan Hua · 2018 · 1041 citations · Cited by this paper
  10. Ultrasensitive detection of NSE lung cancer biomarker using label-free electrochemical biosensor based on carbon nanotube and graphene quantum dots nanocomposite · 2026 · Related
  11. Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases · Denzil L. Furtado · 2018 · 704 citations · Cited by this paper
  12. From angiomiRs to nanomedicine: Self-assembling lipid hybrid nanocarriers for microRNA delivery in lung cancer · 2026 · Related
  13. Developing a new class of engineered live bacterial therapeutics to treat human diseases · Mark R. Charbonneau · 2020 · 522 citations · Cited by this paper
  14. Melanin chelating zinc ions for NIR-I photoacoustic imaging-guided photothermal-pyroptosis therapy of breast cancer · 2026 · Related
  15. Tumor Cell-Targeting and Tumor Microenvironment–Responsive Nanoplatforms for the Multimodal Imaging-Guided Photodynamic/Photothermal/Chemodynamic Treatment of Cervical Cancer · Ying Wang · 2024 · 516 citations · Cited by this paper
  16. Nanotechnology-based reformulation of AUY922 mitigates retinal toxicity and retains potent anti-tumor activity · 2026 · Related
  17. Programmable probiotics for detection of cancer in urine · Tal Danino · 2015 · 479 citations · Cited by this paper
  18. Nose-to-brain delivery of an amyloid beta blocking peptide using polylactic acid-poloxamer 188 nanocarriers · 2026 · Related
  19. Metal organic framework coated MnO2 nanosheets delivering doxorubicin and self-activated DNAzyme for chemo-gene combinatorial treatment of cancer · Yunbo Nie · 2020 · 466 citations · Cited by this paper
  20. Advances in biocontainment strategies of engineered microbes for use in humans · 2026 · Related
  21. Clinical translation of nanomedicines: Challenges, opportunities, and keys · Mahmoud A. Younis · 2021 · 459 citations · Cited by this paper
  22. Engineering bacteria as interactive cancer therapies · Candice R. Gurbatri · 2022 · 451 citations · Cited by this paper
  23. Delivering the power of nanomedicine to patients today · Matthieu Germain · 2020 · 404 citations · Cited by this paper
  24. Vat polymerization-based bioprinting—process, materials, applications and regulatory challenges · Wei Long Ng · 2019 · 403 citations · Cited by this paper
  25. Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer · Katsuhiko Nosho · 2016 · 362 citations · Cited by this paper
  26. Molecular Pathways: Mechanism of Action for Talimogene Laherparepvec, a New Oncolytic Virus Immunotherapy · Frederick J. Kohlhapp · 2015 · 308 citations · Cited by this paper
  27. PLGA-based nanomedicines manufacturing: Technologies overview and challenges in industrial scale-up · Maria Camilla Operti · 2021 · 302 citations · Cited by this paper
  28. Next-generation biocontainment systems for engineered organisms · Jeong Wook Lee · 2018 · 281 citations · Cited by this paper
  29. Microbiome at the Frontier of Personalized Medicine · Purna Kashyap · 2017 · 275 citations · Cited by this paper
  30. Probiotic-guided CAR-T cells for solid tumor targeting · Rosa L. Vincent · 2023 · 273 citations · Cited by this paper
  31. Insights into Pathogenic Interactions Among Environment, Host, and Tumor at the Crossroads of Molecular Pathology and Epidemiology · Shuji Ogino · 2018 · 253 citations · Cited by this paper
  32. Intratumoural microbiota: a new frontier in cancer development and therapy · Yaqi Cao · 2024 · 247 citations · Cited by this paper
  33. Stimuli-Responsive Nanomaterials for Application in Antitumor Therapy and Drug Delivery · Son H. Pham · 2020 · 244 citations · Cited by this paper
  34. Metabolic Model-Based Integration of Microbiome Taxonomic and Metabolomic Profiles Elucidates Mechanistic Links between Ecological and Metabolic Variation · Cecilia A. Noecker · 2016 · 231 citations · Cited by this paper
  35. Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy · Rong Sun · 2022 · 196 citations · Cited by this paper
  36. Immunotherapy and the ovarian cancer microenvironment: Exploring potential strategies for enhanced treatment efficacy · Zhibin Wang · 2024 · 196 citations · Cited by this paper
  37. Review Article · Shuji Ogino · 2016 · 177 citations · Cited by this paper
  38. Design of nanocarriers for nanoscale drug delivery to enhance cancer treatment using hybrid polymer and lipid building blocks · Ruixue Zhang · 2016 · 175 citations · Cited by this paper
  39. Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies · Jason J. Luke · 2023 · 170 citations · Cited by this paper

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