Research map: An inducible signal 1 booster overcomes limited access to antigen for solid tumor cell therapy

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  1. Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication · Christopher C. Kloss · 2018 · 646 citations · Cited by this paper
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  5. A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors · Xiaojun Liu · 2016 · 533 citations · Cited by this paper
  6. Depletion of IL-10 in CAR-NK cells augments reprogramming of the tumor microenvironment and ameliorates therapeutic efficacy · 2026 · Related
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  9. Co-opting signalling molecules enables logic-gated control of CAR T cells · Aidan M. Tousley · 2023 · 320 citations · Cited by this paper
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  11. CLDN6-specific CAR-T cells plus amplifying RNA vaccine in relapsed or refractory solid tumors: the phase 1 BNT211-01 trial · Andréas Mackensen · 2023 · 294 citations · Cited by this paper
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  13. Discovery of Mesothelin and Exploiting It as a Target for Immunotherapy · Ira H Pastan · 2014 · 254 citations · Cited by this paper
  14. Intraperitoneal delivery of the oncolytic virus CF17 improves tumor immunogenicity and survival in gastric cancer peritoneal metastasis · 2026 · Related
  15. Strategies to Address Chimeric Antigen Receptor Tonic Signaling · Adam Ajina · 2018 · 247 citations · Cited by this paper
  16. Synergistic Cell-Cycle Repression by HDAC/EZH2 Co-Targeting in H3K27-Altered Diffuse Midline Glioma · 2026 · Related
  17. Rapamycin Analogs with Differential Binding Specificity Permit Orthogonal Control of Protein Activity · J. Henri Bayle · 2006 · 218 citations · Cited by this paper
  18. Natural killer cell-derived extracellular vesicles reprogram cellular human immunity to enhance tumor cytotoxicity · 2026 · Related
  19. Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness · Jian Chen · 2023 · 188 citations · Cited by this paper
  20. Optimizing CAR T cell therapy in pancreatic cancer through clinically actionable combinations · 2026 · Related
  21. Optimized gene engineering of murine CAR-T cells reveals the beneficial effects of IL-15 coexpression · Evripidis Lanitis · 2020 · 164 citations · Cited by this paper
  22. High-Affinity Interactions of Tumor Necrosis Factor Receptor-Associated Factors (TRAFs) and CD40 Require TRAF Trimerization and CD40 Multimerization · Steven S. Pullen · 1999 · 149 citations · Cited by this paper
  23. Intravenous Safety and Pharmacokinetics of a Novel Dimerizer Drug, AP1903, in Healthy Volunteers · John D. Iuliucci · 2001 · 130 citations · Cited by this paper
  24. Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40 · Aaron Edward Foster · 2017 · 107 citations · Cited by this paper
  25. Constitutively active MyD88/CD40 costimulation enhances expansion and efficacy of chimeric antigen receptor T cells targeting hematological malignancies · Matthew R. Collinson-Pautz · 2019 · 90 citations · Cited by this paper
  26. Recombinant adeno-associated virus mediates a high level of gene transfer but less efficient integration in the K562 human hematopoietic cell line · Punam Malik · 1997 · 85 citations · Cited by this paper
  27. Dynamic chromatin regulatory landscape of human CAR T cell exhaustion · David G. Gennert · 2021 · 69 citations · Cited by this paper
  28. Mesothelin-specific CAR-T cell therapy that incorporates an HLA-gated safety mechanism selectively kills tumor cells · Talar Tokatlian · 2022 · 69 citations · Cited by this paper
  29. Analysis of CAR-Mediated Tonic Signaling · Hugo Calderón · 2019 · 64 citations · Cited by this paper
  30. Dual Targeting of Mesothelin and CD19 with Chimeric Antigen Receptor-Modified T Cells in Patients with Metastatic Pancreatic Cancer · Andrew H. Ko · 2020 · 61 citations · Cited by this paper
  31. A composite MyD88/CD40 switch synergistically activates mouse and human dendritic cells for enhanced antitumor efficacy · Priyadharshini Narayanan · 2011 · 56 citations · Cited by this paper
  32. Engineered T cells directed at tumors with defined allelic loss · Agnes E. Hamburger · 2020 · 55 citations · Cited by this paper
  33. PSCA-targeted BPX-601 CAR T cells with pharmacological activation by rimiducid in metastatic pancreatic and prostate cancer: a phase 1 dose escalation trial · Mark N. Stein · 2024 · 49 citations · Cited by this paper
  34. The Tmod cellular logic gate as a solution for tumor-selective immunotherapy · Breanna DiAndreth · 2022 · 28 citations · Cited by this paper
  35. Mechanism of MyD88S mediated signal termination · Katarzyna Pustelny · 2022 · 27 citations · Cited by this paper
  36. Structure-function relationships of chimeric antigen receptors in acute T cell responses to antigen · Xu Han · 2020 · 19 citations · Cited by this paper
  37. Tailoring CAR surface density and dynamics to improve CAR-T cell therapy · Ana Hinckley-Boned · 2025 · 19 citations · Cited by this paper
  38. Conduit CAR: Redirecting CAR T-Cell Specificity with A Universal and Adaptable Bispecific Antibody Platform · M. Jack Borrok · 2022 · 14 citations · Cited by this paper
  39. Multi-targeted, NOT gated CAR-T cells as a strategy to protect normal lineages for blood cancer therapy · Breanna DiAndreth · 2025 · 13 citations · Cited by this paper

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